دورية أكاديمية
Aging is associated with an altered macrophage response during human skeletal muscle regeneration.
| العنوان: | Aging is associated with an altered macrophage response during human skeletal muscle regeneration. |
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| المؤلفون: | Ahmadi M; Department of Exercise Sciences, Brigham Young University, Provo, UT 84602, USA., Karlsen A; Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark; Center for Healthy Aging, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Mehling J; Department of Exercise Sciences, Brigham Young University, Provo, UT 84602, USA., Soendenbroe C; Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark; Center for Healthy Aging, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Mackey AL; Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark; Center for Healthy Aging, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: abigailmac@sund.ku.dk., Hyldahl RD; Department of Exercise Sciences, Brigham Young University, Provo, UT 84602, USA. Electronic address: robhyldahl@byu.edu. |
| المصدر: | Experimental gerontology [Exp Gerontol] 2022 Nov; Vol. 169, pp. 111974. Date of Electronic Publication: 2022 Oct 11. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: England NLM ID: 0047061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6815 (Electronic) Linking ISSN: 05315565 NLM ISO Abbreviation: Exp Gerontol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Tarrytown Ny : Elsevier Science Original Publication: Oxford. |
| مواضيع طبية MeSH: | Macrophages*/physiology , Muscle, Skeletal*/physiology, Humans ; Aged ; Aging ; Regeneration ; Wound Healing |
| مستخلص: | Skeletal muscle injury in aged rodents is characterized by an asynchronous infiltration of pro- and anti-inflammatory macrophage waves, leading to improper and incomplete regeneration. It is unclear whether this aberration also occurs in aged human muscle. In this study, we quantified the macrophage responses in a human model of muscle damage and regeneration induced by electrical stimulation in 7 young and 21 older adults. At baseline, total resident macrophage (CD68 + /DAPI + ) content was not different between young and old subjects, but pro-inflammatory (CD206 - /CD68 + /DAPI + ) macrophage content was lower in the old. Following damage, muscle Infiltration of CD206 - /CD68 + /DAPI + macrophages was lower in old relative to young subjects. Further, only the increase in CD206 - /CD68 + macrophages correlated with the change in muscle satellite cell content. Our data show that older individuals have a compromised macrophage response during muscle regeneration, pointing to an altered inflammatory response as a potential mechanism for reduced muscle regenerative efficacy in aged humans. Competing Interests: Declaration of competing interest None. (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Aging; Immunosenescence; Inflammation; Muscle damage; Muscle regeneration; Satellite cell |
| تواريخ الأحداث: | Date Created: 20221013 Date Completed: 20221101 Latest Revision: 20221213 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/j.exger.2022.111974 |
| PMID: | 36228835 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-6815 |
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| DOI: | 10.1016/j.exger.2022.111974 |