دورية أكاديمية
Serum Calcitonin Gene-Related Peptide Is Elevated in Patients With Migraine and Ophthalmoplegia.
| العنوان: | Serum Calcitonin Gene-Related Peptide Is Elevated in Patients With Migraine and Ophthalmoplegia. |
|---|---|
| المؤلفون: | Takkar A; Departments of Neurology (AT, VL), Internal Medicine (KVAK), Ophthalmology (DK), Radiodiagnosis (PS), Immunopathology (RM, SA), and Community Medicine and School of Public Health (SK), Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India ; The Headache and Migraine Clinics (KR), Jaslok and Lilavati Hospitals, Mumbai, India; and Beth Israel Deaconess Medical Center (LC) (LRC), and Department of Neurology (LC), Harvard University, Boston, Massachusetts., Kumar KVA, Katoch D, Singh P, Minz R, Anand S, Kathirvel S, Ravishankar K, Lal V, Caplan LR |
| المصدر: | Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society [J Neuroophthalmol] 2023 Sep 01; Vol. 43 (3), pp. 399-405. Date of Electronic Publication: 2022 Oct 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9431308 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-5166 (Electronic) Linking ISSN: 10708022 NLM ISO Abbreviation: J Neuroophthalmol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <1999->: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: New York, NY : Raven Press, c1994- |
| مواضيع طبية MeSH: | Migraine Disorders*/complications , Migraine Disorders*/diagnosis , Ophthalmoplegia*/diagnosis , Ophthalmoplegic Migraine*/diagnosis, Humans ; Calcitonin Gene-Related Peptide ; Case-Control Studies ; Headache/diagnosis |
| مستخلص: | Background: There is ongoing debate about whether the oculomotor (III), trochlear (IV), or abducens (VI) nerve paresis in patients with migraine is directly attributable to migraine (ophthalmoplegic migraine [OM]) or is due to an inflammatory neuropathy (recurrent painful ophthalmoplegic neuropathy [RPON]). As migraine is associated with elevated serum calcitonin gene-related peptide (CGRP) levels, we studied serum CGRP levels among patients with OM/RPON to determine whether they are elevated during and between attacks. This is the first study assessing CGRP levels in the serum of patients with OM/RPON. Methods: The aim of this case-control study was to assess serum CGRP levels in patients with ophthalmoplegia and a headache consistent with migraine according to ICHD-3 criteria. Serum CGRP levels were measured during the ictal and interictal phases in 15 patients with OM/RPON and compared with age-matched and sex-matched controls without migraine (12 patients). Results: The median serum CGRP levels were significantly elevated ( P = 0.021) during the ictal phase (37.2 [36.4, 43.6] ng/L) compared with controls (32.5 [30.1, 37.3] ng/L). Serum CGRP levels during the attack correlated with the total duration of ophthalmoplegia. A CGRP level of 35.5 ng/L in the ictal phase of the attack had a sensitivity of 86.7% and specificity of 75.0% in diagnosing a patient with OM/RPON. Conclusions: Elevated serum CGRP levels during the ictal phase of OM/RPON favor migraine as the underlying cause of episodic headache with ophthalmoplegia. Competing Interests: The authors report no conflicts of interest. (Copyright © 2022 by North American Neuro-Ophthalmology Society.) |
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| المشرفين على المادة: | JHB2QIZ69Z (Calcitonin Gene-Related Peptide) |
| تواريخ الأحداث: | Date Created: 20221018 Date Completed: 20230822 Latest Revision: 20230822 |
| رمز التحديث: | 20230822 |
| DOI: | 10.1097/WNO.0000000000001695 |
| PMID: | 36255114 |
| قاعدة البيانات: | MEDLINE |
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