دورية أكاديمية
The effect of thyroid dysfunction on breast cancer risk: an updated meta-analysis.
| العنوان: | The effect of thyroid dysfunction on breast cancer risk: an updated meta-analysis. |
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| المؤلفون: | Tran TV; Cancer and Radiation Group, Center for Research in Epidemiology and Population Health, INSERM, Paris Sud-Paris Saclay University, Gustave Roussy, Villejuif, France.; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Kitahara CM; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Leenhardt L; Thyroid and Endocrine Tumors Unit, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France., de Vathaire F; Cancer and Radiation Group, Center for Research in Epidemiology and Population Health, INSERM, Paris Sud-Paris Saclay University, Gustave Roussy, Villejuif, France., Boutron-Ruault MC; Health across Generations Team, Center for Research in Epidemiology and Population Health, INSERM, Paris Sud-Paris Saclay University, Gustave Roussy, Villejuif, France., Journy N; Cancer and Radiation Group, Center for Research in Epidemiology and Population Health, INSERM, Paris Sud-Paris Saclay University, Gustave Roussy, Villejuif, France. |
| المصدر: | Endocrine-related cancer [Endocr Relat Cancer] 2022 Dec 12; Vol. 30 (1). Date of Electronic Publication: 2022 Dec 12 (Print Publication: 2023). |
| نوع المنشور: | Meta-Analysis; Review; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioScientifica Country of Publication: England NLM ID: 9436481 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1479-6821 (Electronic) Linking ISSN: 13510088 NLM ISO Abbreviation: Endocr Relat Cancer Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Bristol, UK : BioScientifica Original Publication: Woodlands, Almondsbury, Bristol, UK : Published for the Society of Endocrinology by the Journal of Endocrinology Ltd., 1994- |
| مواضيع طبية MeSH: | Breast Neoplasms*/complications , Thyroid Diseases*/complications , Hyperthyroidism*/complications , Hyperthyroidism*/epidemiology , Hypothyroidism*/epidemiology, Female ; Humans ; Thyrotropin ; Thyroid Hormones |
| مستخلص: | In a previous systematic review and meta-analysis of studies reporting associations between hyper-/hypothyroidism and breast cancer incidence published through 29 January 2019, we identified a higher risk with diagnosed hyperthyroidism compared to euthyroidism, but no association with diagnosed hypothyroidism. This 2-year updated meta-analysis aims to investigate the role of menopause in this association and the dose-response relationship with blood levels of thyroid-stimulating hormone (TSH) and thyroid hormones. After the exclusion of studies with only mortality follow-up, with thyroid dysfunction evaluated as a cancer biomarker or after prior breast cancer diagnosis, we reviewed 25 studies that were published up to 01 December 2021 and identified in MEDLINE, the COCHRANE library, Embase, or Web of Science; of these, 9 were included in the previous meta-analysis. Risk estimates from 22 of the 25 studies were included in the meta-analysis and pooled using random-effects models. Compared to euthyroidism, hyperthyroidism and hypothyroidism diagnoses were associated with higher (pooled risk ratio (RR): 1.12, 95% CI: 1.06-1.18, 3829 exposed cases) and lower risks (RR = 0.93, 95% CI: 0.86-1.00, 5632 exposed cases) of breast cancer, respectively. The increased risk after hyperthyroidism was greater among postmenopausal women (RR = 1.19, 95% CI 1.09-1.30) and the decreased risk after hypothyroidism was more pronounced among premenopausal women (RR = 0.69, 95% CI 0.53-0.89). Among women with no prior history of thyroid disease, every 1 mIU/L increase in TSH level was associated with a 0.8% (95% CI > 0-1.5%) lower risk of breast cancer. In conclusion, this meta-analysis supports an association between thyroid hormone levels and breast cancer risk, which could be modified by menopausal status. |
| فهرسة مساهمة: | Keywords: breast cancer; epidemiological studies; hyperthyroidism; hypothyroidism; incidence; meta-analysis |
| المشرفين على المادة: | 9002-71-5 (Thyrotropin) 0 (Thyroid Hormones) |
| تواريخ الأحداث: | Date Created: 20221018 Date Completed: 20221214 Latest Revision: 20221222 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1530/ERC-22-0155 |
| PMID: | 36256851 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1479-6821 |
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| DOI: | 10.1530/ERC-22-0155 |