دورية أكاديمية
Cortical gyrification differences between early- and late-onset obsessive-compulsive disorder: neurobiological evidence for neurodevelopmentally distinct subtypes.
| العنوان: | Cortical gyrification differences between early- and late-onset obsessive-compulsive disorder: neurobiological evidence for neurodevelopmentally distinct subtypes. |
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| المؤلفون: | Park I; Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea., Ha M; Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea., Kim T; Department of Bio and Brain, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea., Lho SK; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea., Moon SY; Department of Psychiatry, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea., Kim M; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea., Kwon JS; Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea.; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.; Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea. |
| المصدر: | Psychological medicine [Psychol Med] 2023 Oct; Vol. 53 (13), pp. 5976-5985. Date of Electronic Publication: 2022 Oct 19. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cambridge University Press Country of Publication: England NLM ID: 1254142 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-8978 (Electronic) Linking ISSN: 00332917 NLM ISO Abbreviation: Psychol Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Cambridge University Press Original Publication: London, British Medical Assn. |
| مواضيع طبية MeSH: | Obsessive-Compulsive Disorder*/diagnostic imaging , Obsessive-Compulsive Disorder*/epidemiology, Humans ; Parietal Lobe ; Brain ; Gyrus Cinguli/diagnostic imaging ; Phenotype ; Late Onset Disorders ; Magnetic Resonance Imaging |
| مستخلص: | Background: Identifying more homogenous subtypes of patients with obsessive-compulsive disorder (OCD) using biological evidence is critical for understanding complexities of the disorder in this heterogeneous population. Age of onset serves as a useful subtyping scheme for distinguishing OCD into two subgroups that aligns with neurodevelopmental perspectives. The underlying neurobiological markers for these distinct neurodevelopmental differences can be identified by investigating gyrification changes to establish biological evidence-based homogeneous subtypes. Methods: We compared whole-brain cortical gyrification in 84 patients with early-onset OCD, 84 patients with late-onset OCD, and 152 healthy controls (HCs) to identify potential markers for early neurodevelopmental deficits using the local gyrification index (lGI). Then, the relationships between lGI in clusters showing significant differences and performance in visuospatial memory and verbal fluency, which are considered trait-related neurocognitive impairments in OCD, were further examined in early-onset OCD patients. Results: The early-onset OCD patients exhibited significantly greater gyrification than those with late-onset OCD patients and HCs in frontoparietal and cingulate regions, including the bilateral precentral, postcentral, precuneus, paracentral, posterior cingulate, superior frontal, and caudal anterior cingulate gyri. Moreover, impaired neurocognitive functions in early-onset OCD patients were correlated with increased gyrification. Conclusions: Our findings provide a neurobiological marker to distinguish the OCD population into more neurodevelopmentally homogeneous subtypes, which may contribute to the understanding of the neurodevelopmental underpinnings of an etiology in early-onset OCD consistent with the accumulated phenotypic evidence of greater neurodevelopmental deficits in early-onset OCD than in late-onset OCD. |
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| فهرسة مساهمة: | Keywords: Cortical folding; gyrification; neurodevelopment; obsessive–compulsive disorder; onset age; subtypes; verbal fluency; visuospatial memory |
| تواريخ الأحداث: | Date Created: 20221019 Date Completed: 20231023 Latest Revision: 20231025 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10520599 |
| DOI: | 10.1017/S0033291722003129 |
| PMID: | 36259417 |
| قاعدة البيانات: | MEDLINE |
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