دورية أكاديمية

BCG Vaccine-The Road Not Taken.

التفاصيل البيبلوغرافية
العنوان: BCG Vaccine-The Road Not Taken.
المؤلفون: Dow CT; Department of Ophthalmology and Visual Sciences, McPherson Eye Research Institute, Madison, WI 53705, USA.; Mindful Diagnostics and Therapeutics, Eau Claire, WI 54701, USA., Kidess L; Department of Biochemistry, University of St. Thomas, St. Paul, MN 55105, USA.
المصدر: Microorganisms [Microorganisms] 2022 Sep 27; Vol. 10 (10). Date of Electronic Publication: 2022 Sep 27.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101625893 Publication Model: Electronic Cited Medium: Print ISSN: 2076-2607 (Print) Linking ISSN: 20762607 NLM ISO Abbreviation: Microorganisms Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2013]-
مستخلص: The Bacillus Calmette-Guérin (BCG) vaccine has been used for over one hundred years to protect against the most lethal infectious agent in human history, tuberculosis. Over four billion BCG doses have been given and, worldwide, most newborns receive BCG. A few countries, including the United States, did not adopt the WHO recommendation for routine use of BCG. Moreover, within the past several decades, most of Western Europe and Australia, having originally employed routine BCG, have discontinued its use. This review article articulates the impacts of those decisions. The suggested consequences include increased tuberculosis, increased infections caused by non-tuberculous mycobacteria (NTM), increased autoimmune disease (autoimmune diabetes and multiple sclerosis) and increased neurodegenerative disease (Parkinson's disease and Alzheimer's disease). This review also offers an emerged zoonotic pathogen, Mycobacterium avium ss. paratuberculosis (MAP), as a mostly unrecognized NTM that may have a causal role in some, if not all, of these diseases. Current clinical trials with BCG for varied infectious, autoimmune and neurodegenerative diseases have brought this century-old vaccine to the fore due to its presumed immuno-modulating capacity. With its historic success and strong safety profile, the new and novel applications for BCG may lead to its universal use-putting the Western World back onto the road not taken.
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فهرسة مساهمة: Keywords: Alzheimer’s disease; Bacillus Calmette-Guérin (BCG); Mycobacterium avium ss. paratuberculosis (MAP); Parkinson’s disease; global burden of disease; molecular mimicry; multiple sclerosis; non-tuberculous mycobacteria (NTM); nonspecific effects; trained immunity; tuberculosis; type 1 diabetes
تواريخ الأحداث: Date Created: 20221027 Latest Revision: 20240906
رمز التحديث: 20240906
مُعرف محوري في PubMed: PMC9609351
DOI: 10.3390/microorganisms10101919
PMID: 36296196
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-2607
DOI:10.3390/microorganisms10101919