دورية أكاديمية
The Potential Neuroprotective Effect of Cyperus esculentus L. Extract in Scopolamine-Induced Cognitive Impairment in Rats: Extensive Biological and Metabolomics Approaches.
العنوان: | The Potential Neuroprotective Effect of Cyperus esculentus L. Extract in Scopolamine-Induced Cognitive Impairment in Rats: Extensive Biological and Metabolomics Approaches. |
---|---|
المؤلفون: | Saeed MM; Lecturer of Pharmacology and Toxicology, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt., Fernández-Ochoa Á; Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Avda Fuentenueva s/n, 18071 Granada, Spain., Saber FR; Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt., Sayed RH; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt., Cádiz-Gurrea ML; Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Avda Fuentenueva s/n, 18071 Granada, Spain., Elmotayam AK; Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt., Leyva-Jiménez FJ; Department of Analytical Chemistry and Food Science and Technology, University of Castilla-La Mancha, Ronda de Calatrava, 7, 13071 Ciudad Real, Spain.; Regional Institute for Applied Scientific Research (IRICA), Area of Food Science, University of Castilla-La Mancha, Avenida Camilo Jose Cela, 10, 13071 Ciudad Real, Spain., Segura-Carretero A; Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Avda Fuentenueva s/n, 18071 Granada, Spain., Nadeem RI; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt. |
المصدر: | Molecules (Basel, Switzerland) [Molecules] 2022 Oct 21; Vol. 27 (20). Date of Electronic Publication: 2022 Oct 21. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, c1995- |
مواضيع طبية MeSH: | Cyperus*/chemistry , Neuroprotective Agents*/therapeutic use , Cognitive Dysfunction*/chemically induced , Cognitive Dysfunction*/drug therapy, Animals ; Rats ; Scopolamine/adverse effects ; Antioxidants/metabolism ; Acetylcholine/metabolism ; Amyloid beta-Peptides/metabolism ; Amyloid Precursor Protein Secretases/metabolism ; bcl-2-Associated X Protein/metabolism ; Memory Disorders/chemically induced ; Memory Disorders/drug therapy ; Memory Disorders/metabolism ; Malondialdehyde/metabolism ; Plant Extracts/metabolism ; Flavonoids/metabolism ; Amino Acids/metabolism ; Fatty Acids/metabolism ; Cytokines/metabolism ; Esterases/metabolism |
مستخلص: | The aim of the present study is to investigate the phytochemical composition of tiger nut (TN) ( Cyperus esculentus L.) and its neuroprotective potential in scopolamine (Scop)-induced cognitive impairment in rats. The UHPLC-ESI-QTOF-MS analysis enabled the putative annotation of 88 metabolites, such as saccharides, amino acids, organic acids, fatty acids, phenolic compounds and flavonoids. Treatment with TN extract restored Scop-induced learning and memory impairments. In parallel, TN extract succeeded in lowering amyloid beta, β-secretase protein expression and acetylcholine esterase (AChE) activity in the hippocampus of rats. TN extract decreased malondialdehyde levels, restored antioxidant levels and reduced proinflammatory cytokines as well as the Bax/Bcl2 ratio. Histopathological analysis demonstrated marked neuroprotection in TN-treated groups. In conclusion, the present study reveals that TN extract attenuates Scop-induced memory impairments by diminishing amyloid beta aggregates, as well as its anti-inflammatory, antioxidant, anti-apoptotic and anti-AChE activities. |
References: | Foods. 2022 Feb 19;11(4):. (PMID: 35206077) Antioxidants (Basel). 2021 Feb 08;10(2):. (PMID: 33567537) RSC Adv. 2021 Jan 28;11(10):5295-5310. (PMID: 35423082) J Food Biochem. 2021 Mar;45(3):e13280. (PMID: 32441354) Mol Cell. 2000 Oct;6(4):909-19. (PMID: 11090628) FASEB J. 2021 May;35(5):e21569. (PMID: 33864420) Behav Brain Res. 2019 Jan 1;356:18-40. (PMID: 30118774) Nat Rev Neurosci. 2014 Dec;15(12):771-85. (PMID: 25387473) Traffic. 2021 Sep;22(9):319-327. (PMID: 34189821) Biomed Pharmacother. 2018 Dec;108:1376-1383. (PMID: 30372840) Front Aging Neurosci. 2019 Jun 26;11:155. (PMID: 31293414) Metabolomics. 2007 Sep;3(3):211-221. (PMID: 24039616) Inflammopharmacology. 2022 Apr;30(2):667-681. (PMID: 35249177) Neurol Sci. 2011 Oct;32(5):811-8. (PMID: 21617951) Phytomedicine. 2021 Oct;91:153662. (PMID: 34333326) Biomed Pharmacother. 2018 Jan;97:1096-1101. (PMID: 29136946) EMBO Mol Med. 2016 Jun 01;8(6):595-608. (PMID: 27025652) Behav Brain Res. 2020 Jan 27;378:112314. (PMID: 31644927) Brain Res Bull. 1991 Apr;26(4):613-6. (PMID: 1868359) Intern Med. 2010;49(23):2553-9. (PMID: 21139292) Xenobiotica. 2020 Apr;50(4):389-400. (PMID: 31298070) Drug Metab Pers Ther. 2020 Aug 10;35(3):. (PMID: 32776896) Front Pharmacol. 2017 Nov 21;8:847. (PMID: 29209218) Neural Regen Res. 2013 Apr 25;8(12):1081-90. (PMID: 25206402) Open Access Maced J Med Sci. 2018 Jul 17;6(7):1215-1224. (PMID: 30087724) Pharmacol Rep. 2019 Oct;71(5):818-825. (PMID: 31382167) Neurosci Lett. 2005 Feb 21;374(3):222-6. (PMID: 15663967) Psychopharmacology (Berl). 1988;94(4):491-5. (PMID: 2836875) Behav Brain Res. 2014 Jul 1;267:178-88. (PMID: 24667364) Geriatrics (Basel). 2016 Nov 12;1(4):. (PMID: 31022822) Sci Rep. 2019 Jul 24;9(1):10732. (PMID: 31341184) Metab Brain Dis. 2019 Feb;34(1):173-181. (PMID: 30406376) J Biomed Sci. 2017 Sep 19;24(1):76. (PMID: 28927401) Front Aging Neurosci. 2016 Mar 04;8:38. (PMID: 26973513) Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11370-5. (PMID: 19549874) Nat Methods. 2019 Apr;16(4):299-302. (PMID: 30886413) Phytomedicine. 2019 Sep;62:152970. (PMID: 31181403) Mol Med Rep. 2016 May;13(5):4215-20. (PMID: 27035793) Biomolecules. 2020 Nov 12;10(11):. (PMID: 33198400) Ann Transl Med. 2015 Jun;3(10):136. (PMID: 26207229) Behav Brain Funct. 2019 May 7;15(1):9. (PMID: 31064381) Neurosci Biobehav Rev. 2018 May;88:187-200. (PMID: 29545166) ACS Chem Neurosci. 2014 Feb 19;5(2):83-92. (PMID: 24328060) Nutrients. 2017 May 10;9(5):. (PMID: 28489058) J Ethnopharmacol. 2020 May 23;254:112709. (PMID: 32109543) Neurobiol Aging. 2002 Sep-Oct;23(5):861-80. (PMID: 12392791) J Lab Clin Med. 1963 May;61:882-8. (PMID: 13967893) Life Sci. 2019 Sep 15;233:116695. (PMID: 31351082) Indian J Pharmacol. 2021 Jan-Feb;53(1):50-59. (PMID: 33975999) Molecules. 2021 Aug 27;26(17):. (PMID: 34500626) Genes Nutr. 2009 Dec;4(4):309-14. (PMID: 19727886) Cells. 2020 Mar 09;9(3):. (PMID: 32182943) Biomed Pharmacother. 2019 Jan;109:1488-1497. (PMID: 30551400) Curr Med Chem. 2011;18(34):5289-302. (PMID: 22087826) Metab Brain Dis. 2017 Apr;32(2):321-329. (PMID: 27631101) Pharm Biol. 2013 Jul;51(7):825-35. (PMID: 23627469) Evid Based Complement Alternat Med. 2021 Aug 10;2021:5577163. (PMID: 34422074) J Cell Sci. 2003 Dec 15;116(Pt 24):4965-75. (PMID: 14625390) Front Immunol. 2021 Jul 15;12:702048. (PMID: 34335614) Drug Chem Toxicol. 2022 May;45(3):1073-1080. (PMID: 32847424) BMC Complement Altern Med. 2018 May 2;18(1):136. (PMID: 29716575) Anal Biochem. 1978 May;86(1):271-8. (PMID: 655387) Evid Based Complement Alternat Med. 2021 May 31;2021:6610864. (PMID: 34194520) Biofactors. 2021 Mar;47(2):190-197. (PMID: 33098588) Methods Mol Biol. 2017;1550:339-368. (PMID: 28188540) Alzheimers Res Ther. 2017 Aug 9;9(1):60. (PMID: 28793924) Pharmacol Rep. 2015 Apr;67(2):195-203. (PMID: 25712639) Brain Res Bull. 2007 Oct 19;74(5):329-35. (PMID: 17845907) Front Endocrinol (Lausanne). 2017 Apr 04;8:60. (PMID: 28421037) Molecules. 2020 Sep 15;25(18):. (PMID: 32942704) BMC Bioinformatics. 2010 Jul 23;11:395. (PMID: 20650010) Fitoterapia. 2011 Jun;82(4):513-23. (PMID: 21277359) Nat Prod Res. 2008;22(17):1487-97. (PMID: 19023813) Plants (Basel). 2019 Nov 07;8(11):. (PMID: 31703432) J Vis Exp. 2008 Sep 24;(19):. (PMID: 19066539) |
فهرسة مساهمة: | Keywords: Cyperus esculentus; UHPLC-ESI-QTOF-MS/MS; foodomics; memory impairments; metabolomics; scopolamine; tiger nut |
المشرفين على المادة: | DL48G20X8X (Scopolamine) 0 (Neuroprotective Agents) 0 (Antioxidants) N9YNS0M02X (Acetylcholine) 0 (Amyloid beta-Peptides) EC 3.4.- (Amyloid Precursor Protein Secretases) 0 (bcl-2-Associated X Protein) 4Y8F71G49Q (Malondialdehyde) 0 (Plant Extracts) 0 (Flavonoids) 0 (Amino Acids) 0 (Fatty Acids) 0 (Cytokines) EC 3.1.- (Esterases) |
تواريخ الأحداث: | Date Created: 20221027 Date Completed: 20221028 Latest Revision: 20221030 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC9606906 |
DOI: | 10.3390/molecules27207118 |
PMID: | 36296710 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1420-3049 |
---|---|
DOI: | 10.3390/molecules27207118 |