دورية أكاديمية
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The Potential Neuroprotective Effect of Cyperus esculentus L. Extract in Scopolamine-Induced Cognitive Impairment in Rats: Extensive Biological and Metabolomics Approaches.

التفاصيل البيبلوغرافية
العنوان: The Potential Neuroprotective Effect of Cyperus esculentus L. Extract in Scopolamine-Induced Cognitive Impairment in Rats: Extensive Biological and Metabolomics Approaches.
المؤلفون: Saeed MM; Lecturer of Pharmacology and Toxicology, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt., Fernández-Ochoa Á; Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Avda Fuentenueva s/n, 18071 Granada, Spain., Saber FR; Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt., Sayed RH; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt., Cádiz-Gurrea ML; Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Avda Fuentenueva s/n, 18071 Granada, Spain., Elmotayam AK; Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt., Leyva-Jiménez FJ; Department of Analytical Chemistry and Food Science and Technology, University of Castilla-La Mancha, Ronda de Calatrava, 7, 13071 Ciudad Real, Spain.; Regional Institute for Applied Scientific Research (IRICA), Area of Food Science, University of Castilla-La Mancha, Avenida Camilo Jose Cela, 10, 13071 Ciudad Real, Spain., Segura-Carretero A; Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Avda Fuentenueva s/n, 18071 Granada, Spain., Nadeem RI; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2022 Oct 21; Vol. 27 (20). Date of Electronic Publication: 2022 Oct 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Cyperus*/chemistry , Neuroprotective Agents*/therapeutic use , Cognitive Dysfunction*/chemically induced , Cognitive Dysfunction*/drug therapy, Animals ; Rats ; Scopolamine/adverse effects ; Antioxidants/metabolism ; Acetylcholine/metabolism ; Amyloid beta-Peptides/metabolism ; Amyloid Precursor Protein Secretases/metabolism ; bcl-2-Associated X Protein/metabolism ; Memory Disorders/chemically induced ; Memory Disorders/drug therapy ; Memory Disorders/metabolism ; Malondialdehyde/metabolism ; Plant Extracts/metabolism ; Flavonoids/metabolism ; Amino Acids/metabolism ; Fatty Acids/metabolism ; Cytokines/metabolism ; Esterases/metabolism
مستخلص: The aim of the present study is to investigate the phytochemical composition of tiger nut (TN) ( Cyperus esculentus L.) and its neuroprotective potential in scopolamine (Scop)-induced cognitive impairment in rats. The UHPLC-ESI-QTOF-MS analysis enabled the putative annotation of 88 metabolites, such as saccharides, amino acids, organic acids, fatty acids, phenolic compounds and flavonoids. Treatment with TN extract restored Scop-induced learning and memory impairments. In parallel, TN extract succeeded in lowering amyloid beta, β-secretase protein expression and acetylcholine esterase (AChE) activity in the hippocampus of rats. TN extract decreased malondialdehyde levels, restored antioxidant levels and reduced proinflammatory cytokines as well as the Bax/Bcl2 ratio. Histopathological analysis demonstrated marked neuroprotection in TN-treated groups. In conclusion, the present study reveals that TN extract attenuates Scop-induced memory impairments by diminishing amyloid beta aggregates, as well as its anti-inflammatory, antioxidant, anti-apoptotic and anti-AChE activities.
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فهرسة مساهمة: Keywords: Cyperus esculentus; UHPLC-ESI-QTOF-MS/MS; foodomics; memory impairments; metabolomics; scopolamine; tiger nut
المشرفين على المادة: DL48G20X8X (Scopolamine)
0 (Neuroprotective Agents)
0 (Antioxidants)
N9YNS0M02X (Acetylcholine)
0 (Amyloid beta-Peptides)
EC 3.4.- (Amyloid Precursor Protein Secretases)
0 (bcl-2-Associated X Protein)
4Y8F71G49Q (Malondialdehyde)
0 (Plant Extracts)
0 (Flavonoids)
0 (Amino Acids)
0 (Fatty Acids)
0 (Cytokines)
EC 3.1.- (Esterases)
تواريخ الأحداث: Date Created: 20221027 Date Completed: 20221028 Latest Revision: 20221030
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9606906
DOI: 10.3390/molecules27207118
PMID: 36296710
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules27207118