دورية أكاديمية
Posthemorrhagic ventricular dilatation late intervention threshold and associated brain injury.
العنوان: | Posthemorrhagic ventricular dilatation late intervention threshold and associated brain injury. |
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المؤلفون: | Valverde E; Department of Neonatology, La Paz University Hospital, Madrid, Spain.; NeNe Foundation, Madrid, Spain.; Hospital La Paz Institute for Health Research-IdiPAZ, Madrid, Spain., Ybarra M; Department of Neonatology, La Paz University Hospital, Madrid, Spain., Benito AV; Department of Neonatology, La Paz University Hospital, Madrid, Spain., Bravo MC; Department of Neonatology, La Paz University Hospital, Madrid, Spain.; Hospital La Paz Institute for Health Research-IdiPAZ, Madrid, Spain., Pellicer A; Department of Neonatology, La Paz University Hospital, Madrid, Spain.; Hospital La Paz Institute for Health Research-IdiPAZ, Madrid, Spain. |
المصدر: | PloS one [PLoS One] 2022 Oct 27; Vol. 17 (10), pp. e0276446. Date of Electronic Publication: 2022 Oct 27 (Print Publication: 2022). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science |
مواضيع طبية MeSH: | Brain Injuries* , Infant, Premature, Diseases*/diagnostic imaging , Infant, Premature, Diseases*/therapy, Humans ; Infant ; Infant, Newborn ; Cerebral Hemorrhage/diagnostic imaging ; Cerebral Hemorrhage/etiology ; Cerebral Hemorrhage/therapy ; Cerebral Ventricles/diagnostic imaging ; Dilatation ; Infant, Premature ; Retrospective Studies |
مستخلص: | Objective: To systematically assess white matter injury (WMI) in preterm infants with posthemorrhagic ventricular dilatation (PHVD) using a high-threshold intervention strategy. Study Design: This retrospective analysis included 85 preterm infants (≤34 weeks of gestation) with grade 2-3 germinal matrix-intraventricular hemorrhage. Cranial ultrasound (cUS) scans were assessed for WMI and ventricular width and shape. Forty-eight infants developed PHVD, 21 of whom (intervention group) underwent cerebrospinal fluid drainage according to a predefined threshold (ventricular index ≥p97+4 mm or anterior horn width >10 mm, and the presence of frontal horn ballooning). The other 27 infants underwent a conservative approach (non-intervention group). The two PHVD groups were compared regarding ventricular width at two stages: the worst cUS for the non-intervention group (scans showing the largest ventricular measurements) versus pre-intervention cUS in the intervention group, and at term equivalent age. WMI was classified as normal/mild, moderate and severe. Results: The intervention group showed significantly larger ventricular index, anterior horn width and thalamo-occipital diameter than the non-intervention group at the two timepoints. Moderate and severe WMI were more frequent in the infants with PHVD (p<0.001), regardless of management (intervention or conservative management). There was a linear relationship between the severity of PHVD and WMI (p<0.001). Conclusions: Preterm infants with PHVD who undergo a high-threshold intervention strategy associate an increased risk of WMI. Competing Interests: The authors have declared that no competing interest exist. |
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تواريخ الأحداث: | Date Created: 20221027 Date Completed: 20221108 Latest Revision: 20221108 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC9612444 |
DOI: | 10.1371/journal.pone.0276446 |
PMID: | 36301835 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1932-6203 |
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DOI: | 10.1371/journal.pone.0276446 |