Ecological conditions predict the intensity of Hendra virus excretion over space and time from bat reservoir hosts.

التفاصيل البيبلوغرافية
العنوان:	Ecological conditions predict the intensity of Hendra virus excretion over space and time from bat reservoir hosts.
المؤلفون:	Becker DJ; Department of Microbiology and Immunology, Montana State University, Bozeman, Montana, USA.; Department of Biology, University of Oklahoma, Norman, Oklahoma, USA., Eby P; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia.; Centre for Planetary Health and Food Security, Griffith University, Queensland, Australia., Madden W; Department of Microbiology and Immunology, Montana State University, Bozeman, Montana, USA., Peel AJ; Centre for Planetary Health and Food Security, Griffith University, Queensland, Australia., Plowright RK; Department of Microbiology and Immunology, Montana State University, Bozeman, Montana, USA.
المصدر:	Ecology letters [Ecol Lett] 2023 Jan; Vol. 26 (1), pp. 23-36. Date of Electronic Publication: 2022 Oct 30.
نوع المنشور:	Letter
اللغة:	English
بيانات الدورية:	Publisher: Blackwell Publishing Country of Publication: England NLM ID: 101121949 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1461-0248 (Electronic) Linking ISSN: 1461023X NLM ISO Abbreviation: Ecol Lett Subsets: MEDLINE
أسماء مطبوعة:	Publication: Oxford, UK : Blackwell Publishing Original Publication: Oxford, UK : [Paris, France] : Blackwell Science ; Centre national de la recherche scientifique, c1998-
مواضيع طبية MeSH:	Hendra Virus* , Chiroptera*, Animals ; Australia ; Seasons
مستخلص:	The ecological conditions experienced by wildlife reservoirs affect infection dynamics and thus the distribution of pathogen excreted into the environment. This spatial and temporal distribution of shed pathogen has been hypothesised to shape risks of zoonotic spillover. However, few systems have data on both long-term ecological conditions and pathogen excretion to advance mechanistic understanding and test environmental drivers of spillover risk. We here analyse three years of Hendra virus data from nine Australian flying fox roosts with covariates derived from long-term studies of bat ecology. We show that the magnitude of winter pulses of viral excretion, previously considered idiosyncratic, are most pronounced after recent food shortages and in bat populations displaced to novel habitats. We further show that cumulative pathogen excretion over time is shaped by bat ecology and positively predicts spillover frequency. Our work emphasises the role of reservoir host ecology in shaping pathogen excretion and provides a new approach to estimate spillover risk. (© 2022 John Wiley & Sons Ltd.)
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معلومات مُعتمدة:	DEB-1716698 National Science Foundation; DE190100710 Australian Research Council; Defense Advanced Research Projects Agency; 1015891 U.S. Department of Agriculture
فهرسة مساهمة:	Keywords: bats; generalised additive models; nutritional stress; pathogen spillover
تواريخ الأحداث:	Date Created: 20221031 Date Completed: 20221226 Latest Revision: 20221226
رمز التحديث:	20221226
DOI:	10.1111/ele.14007
PMID:	36310377
قاعدة البيانات:	MEDLINE

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تدمد:	1461-0248
DOI:	10.1111/ele.14007