دورية أكاديمية
The health and economic impact of switching vaccines in universal varicella vaccination programs using a dynamic transmission model: An Israel case study.
العنوان: | The health and economic impact of switching vaccines in universal varicella vaccination programs using a dynamic transmission model: An Israel case study. |
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المؤلفون: | Kujawski SA; Center for Observational and Real-World Evidence (CORE), Merck & Co. Inc, Rahway, NJ, USA., Burgess C; Biostatistics and Research Decision Sciences - Health Economic Decision Sciences (BARDS-HEDS), Merck & Co. Inc, Rahway, NJ, USA., Agi O; Market Access and External Affairs, MSD, Hod HaSharon, Israel., Attias-Geva Z; Medical Affairs, Vaccines, MSD, Hod HaSharon, Israel., Pillsbury M; Biostatistics and Research Decision Sciences - Health Economic Decision Sciences (BARDS-HEDS), Merck & Co. Inc, Rahway, NJ, USA., Greenberg D; Pediatric Infectious Disease Unit, Ben Gurion University of the Negev, Beer-Sheva, Israel., Bencina G; Center for Observational and Real-World Evidence (CORE), MSD, Madrid, Spain., Pawaskar M; Center for Observational and Real-World Evidence (CORE), Merck & Co. Inc, Rahway, NJ, USA. |
المصدر: | Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2022 Nov 30; Vol. 18 (6), pp. 2124784. Date of Electronic Publication: 2022 Oct 31. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101572652 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2164-554X (Electronic) Linking ISSN: 21645515 NLM ISO Abbreviation: Hum Vaccin Immunother Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2015- : Philadelphia, PA : Taylor & Francis Original Publication: Austin, Tex. : Landes Bioscience |
مواضيع طبية MeSH: | Measles-Mumps-Rubella Vaccine* , Chickenpox*/epidemiology , Chickenpox*/prevention & control, Humans ; Infant ; Chickenpox Vaccine ; Herpesvirus 3, Human ; Vaccines, Combined |
مستخلص: | Currently available health economic models for varicella infection are designed to inform the cost-effectiveness of universal varicella vaccination (UVV) compared with no vaccination. However, in countries with an existing UVV program, these models cannot be used to evaluate whether to continue with the current varicella vaccine or to switch to an alternative vaccine. We developed a dynamic transmission model that incorporates the historical vaccination program to project the health and economic impact of changing vaccination strategies. We applied the model to Israel, which initiated UVV in 2008 with a quadrivalent vaccine, MMRV-GSK, and switched to MMRV-MSD in 2016. The model was calibrated to pre-vaccination incidence data before projecting the impact of the historical and future alternative vaccination strategies on the clinical burden of varicella. Total costs and QALYs lost due to varicella infections were projected to compare continuing with MMRV-MSD versus switching to MMRV-GSK in 2022. Over a 50-year time horizon, continuing with MMRV-MSD reduced varicella incidence further by 64%, reaching 35 cases per 100,000 population by 2072, versus a 136% increase in incidence with MMRV-GSK. Continuing with MMRV-MSD reduced cumulative hospitalization and outpatient cases by 48% and 58% (vs. increase of 137% and 91% with MMRV-GSK), respectively. Continuing with MMRV-MSD resulted in 139 fewer QALYs lost with total cost savings of 3% compared with switching to MMRV-GSK, from the societal perspective. In Israel, maintaining the UVV strategy with MMRV-MSD versus switching to MMRV-GSK is projected to further reduce the burden of varicella and cost less from the societal perspective. |
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فهرسة مساهمة: | Keywords: Varicella; cost-effectiveness; dynamic transmission model; varicella vaccination |
المشرفين على المادة: | 0 (Measles-Mumps-Rubella Vaccine) 0 (Chickenpox Vaccine) 0 (Vaccines, Combined) |
تواريخ الأحداث: | Date Created: 20221031 Date Completed: 20221216 Latest Revision: 20230112 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC9746549 |
DOI: | 10.1080/21645515.2022.2124784 |
PMID: | 36315970 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2164-554X |
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DOI: | 10.1080/21645515.2022.2124784 |