دورية أكاديمية
Nanotechnology-augmented sonodynamic therapy and associated immune-mediated effects for the treatment of pancreatic ductal adenocarcinoma.
| العنوان: | Nanotechnology-augmented sonodynamic therapy and associated immune-mediated effects for the treatment of pancreatic ductal adenocarcinoma. |
|---|---|
| المؤلفون: | Hadi MM; Division of Surgery and Interventional Science, Faculty of Medical Sciences, University College London, London, UK., Farrell S; Biomedical Sciences Research Institute, Ulster University, Coleraine, UK., Nesbitt H; Biomedical Sciences Research Institute, Ulster University, Coleraine, UK., Thomas K; Biomedical Sciences Research Institute, Ulster University, Coleraine, UK., Kubajewska I; Division of Surgery and Interventional Science, Faculty of Medical Sciences, University College London, London, UK.; Nanomerics Ltd, London, UK., Ng A; Division of Surgery and Interventional Science, Faculty of Medical Sciences, University College London, London, UK., Masood H; Division of Surgery and Interventional Science, Faculty of Medical Sciences, University College London, London, UK., Patel S; Division of Surgery and Interventional Science, Faculty of Medical Sciences, University College London, London, UK., Sciscione F; Division of Surgery and Interventional Science, Faculty of Medical Sciences, University College London, London, UK., Davidson B; Division of Surgery and Interventional Science, Faculty of Medical Sciences, University College London, London, UK., Callan JF; Biomedical Sciences Research Institute, Ulster University, Coleraine, UK., MacRobert AJ; Division of Surgery and Interventional Science, Faculty of Medical Sciences, University College London, London, UK., McHale AP; Biomedical Sciences Research Institute, Ulster University, Coleraine, UK., Nomikou N; Division of Surgery and Interventional Science, Faculty of Medical Sciences, University College London, London, UK. n.nomikou@ucl.ac.uk. |
| المصدر: | Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2023 Jul; Vol. 149 (8), pp. 5007-5023. Date of Electronic Publication: 2022 Nov 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7902060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1335 (Electronic) Linking ISSN: 01715216 NLM ISO Abbreviation: J Cancer Res Clin Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin ; New York : Springer-Verlag. |
| مواضيع طبية MeSH: | Ultrasonic Therapy*/methods , Pancreatic Neoplasms*/therapy , Carcinoma, Pancreatic Ductal*/therapy, Animals ; Mice ; Cathepsin B ; Tissue Distribution ; Hematoporphyrins/pharmacology ; Nanotechnology ; Cell Line, Tumor ; Reactive Oxygen Species ; Pancreatic Neoplasms |
| مستخلص: | Purpose: Sonodynamic therapy (SDT) is emerging as a cancer treatment alternative with significant advantages over conventional therapies, including its minimally invasive and site-specific nature, its radical antitumour efficacy with minimal side effects, and its capacity to raise an antitumour immune response. The study explores the efficacy of SDT in combination with nanotechnology against pancreatic ductal adenocarcinoma. Methods: A nanoparticulate formulation (HPNP) based on a cathepsin B-degradable glutamate-tyrosine co-polymer that carries hematoporphyrin was used in this study for the SDT-based treatment of PDAC. Cathepsin B levels in BxPC-3 and PANC-1 cells were correlated to cellular uptake of HPNP. The HPNP efficiency to induce a sonodynamic effect at varying ultrasound parameters, and at different oxygenation and pH conditions, was investigated. The biodistribution, tumour accumulation profile, and antitumour efficacy of HPNP in SDT were examined in immunocompetent mice carrying bilateral ectopic murine pancreatic tumours. The immune response profile of excised tumour tissues was also examined. Results: The HPNP formulation significantly improved cellular uptake of hematoporphyrin for both BxPC-3 and PANC-1 cells, while increase of cellular uptake was positively correlated in PANC-1 cells. There was a clear SDT-induced cytotoxicity at the ultrasound conditions tested, and the treatment impaired the capacity of both BxPC-3 and PANC-1 cells to form colonies. The overall acoustic energy and pulse length, rather than the power density, were key in eliciting the effects observed in vitro. The SDT treatment in combination with HPNP resulted in 21% and 27% reduction of the target and off-target tumour volumes, respectively, within 24 h. A single SDT treatment elicited an antitumour effect that was characterized by an SDT-induced decrease in immunosuppressive T cell phenotypes. Conclusion: SDT has significant potential to serve as a monotherapy or adjunctive treatment for inoperable or borderline resectable PDAC. (© 2022. The Author(s).) |
| التعليقات: | Erratum in: J Cancer Res Clin Oncol. 2023 Mar 22;:. (PMID: 36947238) |
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| معلومات مُعتمدة: | United Kingdom WT_ Wellcome Trust; MC_PC_17180 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: Anticancer immune response; Cathepsin B; Hematoporphyrin; Nanoparticles; Pancreatic cancer; Sonodynamic therapy |
| المشرفين على المادة: | EC 3.4.22.1 (Cathepsin B) 0 (Hematoporphyrins) 0 (Reactive Oxygen Species) |
| تواريخ الأحداث: | Date Created: 20221102 Date Completed: 20230719 Latest Revision: 20231213 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10349707 |
| DOI: | 10.1007/s00432-022-04418-y |
| PMID: | 36319895 |
| قاعدة البيانات: | MEDLINE |
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