دورية أكاديمية
أعرض في EDS

Genomics and metagenomics of Madurella mycetomatis, a causative agent of black grain mycetoma in Sudan.

التفاصيل البيبلوغرافية
العنوان: Genomics and metagenomics of Madurella mycetomatis, a causative agent of black grain mycetoma in Sudan.
المؤلفون: Litvintseva AP; Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America., Bakhiet S; The Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan., Gade L; Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America., Wagner DD; IHRC Inc., Atlanta, Georgia, United States of America., Bagal UR; ASRT Inc. Atlanta, Georgia, United States of America., Batra D; Office of Advanced Molecular Detection, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America., Norris E; Applied Bioinformatics Laboratory, Atlanta, Georgia, United States of America., Rishishwar L; School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, United States of America., Beer KD; Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America., Siddig EE; The Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan., Mhmoud NA; The Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan., Chow NA; Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America., Fahal A; The Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan.
المصدر: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2022 Nov 02; Vol. 16 (11), pp. e0010787. Date of Electronic Publication: 2022 Nov 02 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Madurella*/genetics , Mycetoma*/microbiology, Humans ; Sudan ; Metagenomics ; Genomics ; Neglected Diseases
مستخلص: Madurella mycetomatis is one of the main causative agents of mycetoma, a debilitating neglected tropical disease. Improved understanding of the genomic diversity of the fungal and bacterial causes of mycetoma is essential to advances in diagnosis and treatment. Here, we describe a high-quality genome assembly of M. mycetomatis and results of the whole genome sequence analysis of 26 isolates from Sudan. We demonstrate evidence of at least seven genetically diverse lineages and extreme clonality among isolates within these lineages. We also performed shotgun metagenomic analysis of DNA extracted from mycetoma grains and showed that M. mycetomatis reads were detected in all sequenced samples with the average of 11,317 reads (s.d. +/- 21,269) per sample. In addition, 10 (12%) of the 81 tested grain samples contained bacterial reads including Streptococcus sp., Staphylococcus sp. and others.
Competing Interests: The authors have declared that no competing interests exist.
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تواريخ الأحداث: Date Created: 20221102 Date Completed: 20221104 Latest Revision: 20221110
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9629555
DOI: 10.1371/journal.pntd.0010787
PMID: 36322569
قاعدة البيانات: MEDLINE
الوصف
تدمد:1935-2735
DOI:10.1371/journal.pntd.0010787