دورية أكاديمية
أعرض في EDS

Prevalence of oncogenic human papillomavirus in pregnant adolescents, association with colpocytological changes, risk factors and obstetric outcomes.

التفاصيل البيبلوغرافية
العنوان: Prevalence of oncogenic human papillomavirus in pregnant adolescents, association with colpocytological changes, risk factors and obstetric outcomes.
المؤلفون: de Souza HD; Disciplina de Obstetrícia, Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina, Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil; Departamento Materno Infantil, Faculdade de Medicina, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, MG, Brazil., Waissman AL; Divisão de Clínica Obstétrica, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil., Diório GRM; Departamento de Internato, Faculdade de Medicina, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, MG, Brazil., Peres SV; Divisão de Clínica Obstétrica, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil., Francisco RPV; Disciplina de Obstetrícia, Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina, Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil; Divisão de Clínica Obstétrica, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil., Galletta MAK; Disciplina de Obstetrícia, Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina, Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil. Electronic address: marco.galletta@fm.usp.br.
المصدر: Clinics (Sao Paulo, Brazil) [Clinics (Sao Paulo)] 2022 Oct 31; Vol. 77, pp. 100127. Date of Electronic Publication: 2022 Oct 31 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101244734 Publication Model: eCollection Cited Medium: Internet ISSN: 1980-5322 (Electronic) Linking ISSN: 18075932 NLM ISO Abbreviation: Clinics (Sao Paulo) Subsets: MEDLINE
أسماء مطبوعة: Publication: 2022- : [New York] : Elsevier
Original Publication: São Paulo, SP : Hospital das Clínicas, Faculty of Medicine, University of São Paulo, [2005]-
مواضيع طبية MeSH: Alphapapillomavirus* , Papillomavirus Infections* , Uterine Cervical Neoplasms*, Female ; Pregnancy ; Infant, Newborn ; Humans ; Adolescent ; Papillomaviridae/genetics ; Papanicolaou Test ; Prevalence ; Cross-Sectional Studies ; Brazil/epidemiology ; Risk Factors ; Vaginal Smears
مستخلص: Purpose: The authors aim to carry out an investigation on the impact of cervical oncogenic Human Papillomavirus (HPV) detection in pregnant adolescents, to clarify the prevalence and risk factors, considering the importance and lack of data on this topic in Brazil.
Methods: A cross-sectional study was conducted with adolescents receiving prenatal care in a tertiary hospital in São Paulo, Brazil, with routine Pap smear and oncogenic HPV detection test in the uterine cervix. The authors sought to associate the results of these tests with demographic and obstetric variables.
Results: A total of 303 pregnant adolescents whose mean age was 15.30 ± 1.22 years comprised the study subjects. The frequency of high-risk HPV cervical detection was 50.50%. Multivariate analysis revealed that a large number of partners in their lifetime (OR = 1.27) and having a religion (OR = 2.05) were risk factors for cervical detection of oncogenic HPV, while schooling appeared as a protective factor (OR = 0.85). There was an association between this detection and colpocytological alterations, reaching almost 30% of patients, but without association with obstetric and neonatal outcomes.
Conclusion: The prevalence found is one of the highest in Brazil and worldwide. A greater number of partners during their lifetime and having religion were detected as possible factors associated with cervical HPV detection. Detection of cervical HPV-DNA did not influence obstetric and neonatal outcomes. The findings of this study reinforce the need to implement educational measures capable of modifying the incidence of sexually transmitted infections in this population and capable of promoting adherence to HPV vaccination programs.
Competing Interests: Declaration of Competing Interest The authors declare that they have no conflicts of interest for the subject of this publication. None of the authors received any benefits, financial or non-financial interests, directly or indirectly related to the work submitted for publication.
(Copyright © 2022 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.)
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فهرسة مساهمة: Keywords: Papanicolaou test; Papillomavirus infections; Pregnancy in adolescence; Prenatal care
تواريخ الأحداث: Date Created: 20221103 Date Completed: 20221107 Latest Revision: 20221220
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC9636540
DOI: 10.1016/j.clinsp.2022.100127
PMID: 36327641
قاعدة البيانات: MEDLINE
الوصف
تدمد:1980-5322
DOI:10.1016/j.clinsp.2022.100127