دورية أكاديمية
Pediatric tuberculosis outcomes and factors associated with unfavorable treatment outcomes in Botswana, 2008-2019: a retrospective analysis.
| العنوان: | Pediatric tuberculosis outcomes and factors associated with unfavorable treatment outcomes in Botswana, 2008-2019: a retrospective analysis. |
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| المؤلفون: | Siamisang K; Department of Family Medicine and Public Health, University of Botswana, Gaborone, Botswana. drksiamisang@gmail.com.; Department of Health Services Management, Ministry of Health, Gaborone, Botswana. drksiamisang@gmail.com.; P O Box 40, Letlhakeng, Botswana. drksiamisang@gmail.com., Rankgoane-Pono G; Department of Family Medicine and Public Health, University of Botswana, Gaborone, Botswana., Madisa TM; Department of Health Services Management, Ministry of Health, Gaborone, Botswana., Mudiayi TK; Department of Health Services Management, Ministry of Health, Gaborone, Botswana., Tlhakanelo JT; Department of Family Medicine and Public Health, University of Botswana, Gaborone, Botswana., Mubiri P; Maryland Global Initiative Corporation (MGIC), University of Maryland, Baltimore (UMB), Gaborone, Botswana., Kadimo K; Department of Library Services, University of Botswana, Gaborone, Botswana., Banda FM; Department of Pediatrics, University of Botswana, Gaborone, Botswana., Setlhare V; Department of Family Medicine and Public Health, University of Botswana, Gaborone, Botswana. |
| المصدر: | BMC public health [BMC Public Health] 2022 Nov 04; Vol. 22 (1), pp. 2020. Date of Electronic Publication: 2022 Nov 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 100968562 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2458 (Electronic) Linking ISSN: 14712458 NLM ISO Abbreviation: BMC Public Health Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, [2001- |
| مواضيع طبية MeSH: | HIV Infections*/epidemiology , HIV Infections*/therapy , HIV Infections*/complications , Tuberculosis*/drug therapy , Tuberculosis*/epidemiology, Adult ; Child ; Humans ; Female ; Adolescent ; Child, Preschool ; Retrospective Studies ; Botswana/epidemiology ; Treatment Outcome ; Antitubercular Agents/therapeutic use |
| مستخلص: | Introduction: Globally, the amount of research on the outcomes of pediatric tuberculosis (TB) is disproportionately less than that of adult TB. The diagnosis of paediatric TB is also problematic in developing countries. The aim of this study was to describe the outcomes of pediatric TB in Botswana and to identify the factors associated with unfavorable outcomes. Methods: This was a retrospective analysis of pediatric TB outcomes in Botswana, over a 12-year period from January 2008 to December 2019. Treatment success (treatment completion or cured) was considered a favorable outcome, while death, loss to follow-up and treatment failure were considered unfavorable outcomes. Program data from drug-sensitive TB (DS-TB) cases under the age of 15 years were included. Sampling was exhaustive. Binary logistic regression was used to determine the factors associated with unfavorable outcomes during TB treatment. A p value of < 0.05 was considered a statistically significant association between the predictor variables and unfavorable outcomes. Results: The data of 6,004 paediatric TB cases were extracted from the Botswana National TB Program (BNTP) electronic registry and analyzed. Of these data, 2,948 (49.4%) were of female patients. Of the extracted data, 1,366 (22.8%) were of HIV positive patients and 2,966 (49.4%) were of HIV negative patients. The rest of the data were of patients with unknown HIV status. Pulmonary TB accounted for 4,701 (78.3%) of the cases. Overall, 5,591 (93.1%) of the paediatric TB patient data showed treatment success, 179 (3.0%) were lost to follow-up, 203 (3.4%) records were of patients who died, and 31 (0.5%) were of patients who experienced treatment failure. The factors associated with unfavorable outcomes were positive HIV status (AOR 2.71, 95% CI: 2.09-3.52), unknown HIV status (AOR 2.07, 95% CI: 1.60-2.69) and retreatment category (AOR 1.92, 95% CI: 1.30-2.85). Compared with the 0-4 years age category, the 5-9 years (AOR 0.62, 95% CI: 0.47-0.82) and 10-14 years (AOR 0.76, 95% CI: 0.60-0.98) age categories were less likely to experience the unfavorable outcomes. Conclusion: This study shows a high treatment success rate among paediatric TB cases in Botswana. The government under the National TB Program should maintain and consolidate the gains from this program. Public health interventions should particularly target children with a positive or unknown HIV status, those under 5 years, and those who have been previously treated for TB. (© 2022. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Associated factors; Botswana; Outcomes; Pediatric; Tuberculosis |
| المشرفين على المادة: | 0 (Antitubercular Agents) |
| تواريخ الأحداث: | Date Created: 20221105 Date Completed: 20221108 Latest Revision: 20240928 |
| رمز التحديث: | 20240928 |
| مُعرف محوري في PubMed: | PMC9636819 |
| DOI: | 10.1186/s12889-022-14477-y |
| PMID: | 36333805 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1471-2458 |
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| DOI: | 10.1186/s12889-022-14477-y |