Filtering artifactual signal increases support for Xenacoelomorpha and Ambulacraria sister relationship in the animal tree of life.

التفاصيل البيبلوغرافية
العنوان:	Filtering artifactual signal increases support for Xenacoelomorpha and Ambulacraria sister relationship in the animal tree of life.
المؤلفون:	Mulhair PO; Computational and Molecular Evolutionary Biology Research Group, School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham NG7 2RD, UK; Computational and Molecular Evolutionary Biology Research Group, School of Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK., McCarthy CGP; Computational and Molecular Evolutionary Biology Research Group, School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham NG7 2RD, UK., Siu-Ting K; Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Belfast BT9 5DL, UK., Creevey CJ; Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Belfast BT9 5DL, UK., O'Connell MJ; Computational and Molecular Evolutionary Biology Research Group, School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham NG7 2RD, UK; Computational and Molecular Evolutionary Biology Research Group, School of Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK. Electronic address: mbzmjo@nottingham.ac.uk.
المصدر:	Current biology : CB [Curr Biol] 2022 Dec 05; Vol. 32 (23), pp. 5180-5188.e3. Date of Electronic Publication: 2022 Nov 09.
نوع المنشور:	Journal Article; Research Support, Non-U.S. Gov't
اللغة:	English
بيانات الدورية:	Publisher: Cell Press Country of Publication: England NLM ID: 9107782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0445 (Electronic) Linking ISSN: 09609822 NLM ISO Abbreviation: Curr Biol Subsets: MEDLINE
أسماء مطبوعة:	Publication: Cambridge, MA : Cell Press Original Publication: London, UK : Current Biology Ltd., c1991-
مواضيع طبية MeSH:	Siblings*, Animals ; Humans ; Phylogeny
مستخلص:	Conflicting studies place a group of bilaterian invertebrates containing xenoturbellids and acoelomorphs, the Xenacoelomorpha, as either the primary emerging bilaterian phylum ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ or within Deuterostomia, sister to Ambulacraria. ⁷ ^, ⁸ ^, ⁹ ^, ¹⁰ ^, ¹¹ Although their placement as sister to the rest of Bilateria supports relatively simple morphology in the ancestral bilaterian, their alternative placement within Deuterostomia suggests a morphologically complex ancestral bilaterian along with extensive loss of major phenotypic traits in the Xenacoelomorpha. Recent studies have questioned whether Deuterostomia should be considered monophyletic at all. ¹⁰ ^, ¹² ^, ¹³ Hidden paralogy and poor phylogenetic signal present a major challenge for reconstructing species phylogenies. ¹⁴ ^, ¹⁵ ^, ¹⁶ ^, ¹⁷ ^, ¹⁸ Here, we assess whether these issues have contributed to the conflict over the placement of Xenacoelomorpha. We reanalyzed published datasets, enriching for orthogroups whose gene trees support well-resolved clans elsewhere in the animal tree. ¹⁶ We find that most genes in previously published datasets violate incontestable clans, suggesting that hidden paralogy and low phylogenetic signal affect the ability to reconstruct branching patterns at deep nodes in the animal tree. We demonstrate that removing orthogroups that cannot recapitulate incontestable relationships alters the final topology that is inferred, while simultaneously improving the fit of the model to the data. We discover increased, but ultimately not conclusive, support for the existence of Xenambulacraria in our set of filtered orthogroups. At a time when we are progressing toward sequencing all life on the planet, we argue that long-standing contentious issues in the tree of life will be resolved using smaller amounts of better quality data that can be modeled adequately. ¹⁹ . Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.)
التعليقات:	Comment in: Curr Biol. 2022 Dec 19;32(24):R1340-R1342. (PMID: 36538883)
معلومات مُعتمدة:	BB/R019185/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council
فهرسة مساهمة:	Keywords: Bilateria; Deuterostomia; Xenacoelomorpha; animal phylogeny; hidden paralogy; model fit; orthology; phylogenomics
تواريخ الأحداث:	Date Created: 20221110 Date Completed: 20221215 Latest Revision: 20230123
رمز التحديث:	20230123
DOI:	10.1016/j.cub.2022.10.036
PMID:	36356574
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	1879-0445
DOI:	10.1016/j.cub.2022.10.036