دورية أكاديمية
Mouse Sertoli Cells Inhibit Humoral-Based Immunity.
| العنوان: | Mouse Sertoli Cells Inhibit Humoral-Based Immunity. |
|---|---|
| المؤلفون: | Washburn RL; Immunology and Infectious Disease Concentration, Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center, Lubbock, TX 79424, USA.; Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79424, USA., Kaur G; Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79424, USA.; Department of Medical Education, Texas Tech University Health Sciences Center, Lubbock, TX 79424, USA., Dufour JM; Immunology and Infectious Disease Concentration, Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center, Lubbock, TX 79424, USA.; Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79424, USA.; Department of Medical Education, Texas Tech University Health Sciences Center, Lubbock, TX 79424, USA. |
| المصدر: | International journal of molecular sciences [Int J Mol Sci] 2022 Oct 23; Vol. 23 (21). Date of Electronic Publication: 2022 Oct 23. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2000- |
| مواضيع طبية MeSH: | Immunity, Humoral* , Sertoli Cells*/metabolism, Male ; Humans ; Animals ; Mice ; Graft Survival ; Complement System Proteins/metabolism ; Immune Tolerance ; Graft Rejection |
| مستخلص: | Transplantation is used to treat many different diseases; however, without the use of immunosuppressants, which can be toxic to the patient, grafted tissue is rejected by the immune system. Humoral immune responses, particularly antibodies and complement, are significant components in rejection. Remarkably, Sertoli cells (SCs), immunoregulatory testicular cells, survive long-term after transplantation without immunosuppression. The objective of this study was to assess SC regulation of these humoral-based immune factors. Mouse SCs survived in vitro human complement (model of robust complement-mediated rejection) and survived in vivo as allografts with little-to-no antibody or complement fragment deposition. Microarray data and ELISA analyses identified at least 14 complement inhibitory proteins expressed by mouse SCs, which inhibit complement at multiple points. Interestingly, a mouse SC line (MSC-1), which was rejected by day 20 post transplantation, also survived in vitro human complement, showed limited deposition of antibodies and complement, and expressed complement inhibitors. Together this suggests that SC inhibition of complement-mediated killing is an important component of SC immune regulation. However, other mechanisms of SC immune modulation are also likely involved in SC graft survival. Identifying the mechanisms that SCs use to achieve extended survival as allografts could be utilized to improve graft survival. |
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| معلومات مُعتمدة: | 251206 The CH Foundation |
| فهرسة مساهمة: | Keywords: Sertoli cells; complement; humoral response; transplantation |
| المشرفين على المادة: | 9007-36-7 (Complement System Proteins) |
| تواريخ الأحداث: | Date Created: 20221111 Date Completed: 20221114 Latest Revision: 20221117 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC9656144 |
| DOI: | 10.3390/ijms232112760 |
| PMID: | 36361551 |
| قاعدة البيانات: | MEDLINE |
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