دورية أكاديمية
Wuzi Yanzong Pill Plays A Neuroprotective Role in Parkinson's Disease Mice via Regulating Unfolded Protein Response Mediated by Endoplasmic Reticulum Stress.
| العنوان: | Wuzi Yanzong Pill Plays A Neuroprotective Role in Parkinson's Disease Mice via Regulating Unfolded Protein Response Mediated by Endoplasmic Reticulum Stress. |
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| المؤلفون: | Li YR; The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong, Shanxi Province, 030619, China., Fan HJ; The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong, Shanxi Province, 030619, China., Sun RR; The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong, Shanxi Province, 030619, China., Jia L; The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong, Shanxi Province, 030619, China., Yang LY; The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong, Shanxi Province, 030619, China., Zhang HF; Institute of Brain Science Department, Neurology of First Affiliated Hospital, Shanxi Datong University, Datong, Shanxi Province, 037009, China., Jin XM; Department of Anatomy and Cell Biology, Department of Neurological Surgery, Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Xiao BG; Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200025, China., Ma CG; The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong, Shanxi Province, 030619, China.; Institute of Brain Science Department, Neurology of First Affiliated Hospital, Shanxi Datong University, Datong, Shanxi Province, 037009, China., Chai Z; The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong, Shanxi Province, 030619, China. chaizhi@sxtcm.edu.cn. |
| المصدر: | Chinese journal of integrative medicine [Chin J Integr Med] 2023 Jan; Vol. 29 (1), pp. 19-27. Date of Electronic Publication: 2022 Nov 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Chinese Journal of Integrated Traditional and Western Medicine Press Country of Publication: China NLM ID: 101181180 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1993-0402 (Electronic) Linking ISSN: 16720415 NLM ISO Abbreviation: Chin J Integr Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2007- : Berlin : Chinese Journal of Integrated Traditional and Western Medicine Press : Springer Original Publication: Beijing, China : Watertown, MA : Chinese Association of the Integration of Traditional and Western Medicine : China Academy of Traditional Chinese Medicine ; Distributed by Relaxing Natural Health, [2003]- |
| مواضيع طبية MeSH: | Parkinson Disease*/drug therapy , Parkinson Disease*/metabolism , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/therapeutic use, Mice ; Male ; Animals ; Endoribonucleases/metabolism ; Endoplasmic Reticulum Chaperone BiP ; Caspase 12/metabolism ; Protein Serine-Threonine Kinases/metabolism ; Mice, Inbred C57BL ; Endoplasmic Reticulum Stress ; Unfolded Protein Response ; Disease Models, Animal |
| مستخلص: | Objective: To investigate the protective effects and its possible mechanism of Wuzi Yanzong Pill (WYP) on Parkinson's disease (PD) model mice. Methods: Thirty-six C57BL/6 male mice were randomly assigned to 3 groups including normal, PD, and PD+WYP groups, 12 mice in each group. One week of intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was used to establish the classical PD model in mice. Meanwhile, mice in the PD+WYP group were administrated with 16 g/kg WYP, twice daily by gavage. After 14 days of administration, gait test, open field test and pole test were measured to evaluate the movement function. Tyrosine hydroxylase (TH) neurons in substantia nigra of midbrain and binding immunoglobulin heavy chain protein (GRP78) in striatum and cortex were observed by immunohistochemistry. The levels of TH, GRP78, p-PERK, p-eIF2α, ATF4, p-IRE1α, XBP1, ATF6, CHOP, ASK1, p-JNK, Caspase-12, -9 and -3 in brain were detected by Western blot. Results: Compared with the PD group, WYP treatment ameliorated gait balance ability in PD mice (P<0.05). Similarly, WYP increased the total distance and average speed (P<0.05 or P<0.01), reduced rest time and pole time (P<0.05). Moreover, WYP significantly increased TH positive cells (P<0.01). Immunofluorescence showed WYP attenuated the levels of GRP78 in striatum and cortex. Meanwhile, WYP treatment significantly decreased the protein expressions of GRP78, p-PERK, p-eIF2α, ATF4, p-IRE1 α, XBP1, CHOP, Caspase-12 and Caspase-9 (P<0.05 or P<0.01). Conclusions: WYP ameliorated motor symptoms and pathological lesion of PD mice, which may be related to the regulation of unfolded protein response-mediated signaling pathway and inhibiting the endoplasmic reticulum stress-mediated neuronal apoptosis pathway. (© 2022. The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag GmbH Germany, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Parkinson’s disease; Wuzi Yanzong Pill; apoptosis; dopaminergic neurons; endoplasmic reticulum stress |
| المشرفين على المادة: | 0 (wuzi yanzong) EC 3.1.- (Endoribonucleases) 0 (Endoplasmic Reticulum Chaperone BiP) EC 3.4.22.- (Caspase 12) EC 2.7.11.1 (Protein Serine-Threonine Kinases) 0 (Neuroprotective Agents) |
| تواريخ الأحداث: | Date Created: 20221112 Date Completed: 20221223 Latest Revision: 20221223 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s11655-022-3727-0 |
| PMID: | 36369612 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1993-0402 |
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| DOI: | 10.1007/s11655-022-3727-0 |