Association of PSORS1C3, CARD14 and TLR4 genotypes and haplotypes with psoriasis susceptibility.

التفاصيل البيبلوغرافية
العنوان:	Association of PSORS1C3, CARD14 and TLR4 genotypes and haplotypes with psoriasis susceptibility.
المؤلفون:	Linh NTT; University of Science and Technology, Vietnam Academy of Science and Technology, Ha Noi, Vietnam., Giang NH; Institute of Genome Research, Vietnam Academy of Science and Technology, Ha Noi, Vietnam., Lien NTK; Institute of Genome Research, Vietnam Academy of Science and Technology, Ha Noi, Vietnam., Trang BK; Institute of Genome Research, Vietnam Academy of Science and Technology, Ha Noi, Vietnam., Trang DT; Institute of Genome Research, Vietnam Academy of Science and Technology, Ha Noi, Vietnam., Ngoc NT; University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology, Ha Noi, Vietnam., Nghia VX; 108 Military Central Hospital, Hanoi, Vietnam., My LT; Institute of Genome Research, Vietnam Academy of Science and Technology, Ha Noi, Vietnam., Mao CV; Vietnam Military Medical University, Department of Pathophysiology, Ha Dong, Hanoi, Vietnam., Hoang NH; University of Science and Technology, Vietnam Academy of Science and Technology, Ha Noi, Vietnam.; Institute of Genome Research, Vietnam Academy of Science and Technology, Ha Noi, Vietnam., Xuan NT; University of Science and Technology, Vietnam Academy of Science and Technology, Ha Noi, Vietnam.; Institute of Genome Research, Vietnam Academy of Science and Technology, Ha Noi, Vietnam.
المصدر:	Genetics and molecular biology [Genet Mol Biol] 2022 Nov 07; Vol. 45 (4), pp. e20220099. Date of Electronic Publication: 2022 Nov 07 (Print Publication: 2022).
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Sociedade Brasileira de Genética Country of Publication: Brazil NLM ID: 100883590 Publication Model: eCollection Cited Medium: Print ISSN: 1415-4757 (Print) Linking ISSN: 14154757 NLM ISO Abbreviation: Genet Mol Biol Subsets: PubMed not MEDLINE
أسماء مطبوعة:	Original Publication: Ribeirão Preto, SP, Brazil : Sociedade Brasileira de Genética, 1998-
مستخلص:	Psoriasis is a common chronic, immune-mediated inflammatory disease of the skin. PSORS1C3 is a non-protein coding gene, of which the RNA transcript is found in psoriatic patients. CARD14 is mainly expressed in epidermal keratinocytes. TLR4 is a transmembrane protein to recognize microbial antigens. Our study aimed to assess the relationship among PSORS1C3, CARD14 and TLR4 polymorphisms, inflammatory expression and psoriasis susceptibility. To the end, 71 patients with psoriasis and 46 healthy individuals with the well-characterized clinical profiles were enrolled. Gene polymorphisms were determined by Sanger DNA sequencing and secretion of cytokines by ELISA. As a result, genetic analysis of PSORS1C3 gene identified nine SNPs and three haplotype blocks. Sequencing of the CARD14 gene determined eight SNPs and one haplotype block. Sequencing of TLR4 gene identified nine SNPs, in which a SNP rs1018673641 was found to exert deleterious effect. The linkage disequilibrium analysis showed that seven variants in PSORS1C3 gene and three SNPs in CARD14 gene were in tightly linked. More importantly, a significant association between IL-6 level and rs1018673641 AT genotype in TLR4 gene was detected in psoriatic patients. In conclusion, the PSORS1C3, CARD14 and TLR4 polymorphisms and haplotypes may be correlated with risk of suffering psoriasis and the IL-6-mediated chronic inflammation in psoriasis could be partially regulated by the TLR4 functional variant.
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تواريخ الأحداث:	Date Created: 20221116 Latest Revision: 20221120
رمز التحديث:	20231215
مُعرف محوري في PubMed:	PMC9667706
DOI:	10.1590/1678-4685-GMB-2022-0099
PMID:	36382932
قاعدة البيانات:	MEDLINE

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تدمد:	1415-4757
DOI:	10.1590/1678-4685-GMB-2022-0099