دورية أكاديمية
Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment.
| العنوان: | Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment. |
|---|---|
| المؤلفون: | Schwabkey ZI; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Wiesnoski DH; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Chang CC; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Tsai WB; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Pham D; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Ahmed SS; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Hayase T; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Ortega Turrubiates MR; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., El-Himri RK; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Sanchez CA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Hayase E; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Frenk Oquendo AC; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Miyama T; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Halsey TM; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Heckel BE; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Brown AN; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Jin Y; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Raybaud M; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Prasad R; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Flores I; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., McDaniel L; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Chapa V; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Lorenzi PL; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Warmoes MO; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Tan L; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Swennes AG; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA., Fowler S; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA., Conner M; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA., McHugh K; CPRIT Scholar in Cancer Research, Austin, TX 78701, USA.; Department of Bioengineering, Rice University, Houston, TX 77251, USA., Graf T; Department of Bioengineering, Rice University, Houston, TX 77251, USA., Jensen VB; Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Peterson CB; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Do KA; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Zhang L; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Shi Y; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Wang Y; Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Galloway-Pena JR; Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA., Okhuysen PC; Department of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Daniel-MacDougall CR; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Shono Y; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Burgos da Silva M; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Peled JU; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Weill Cornell Medical College, New York, NY 10021, USA.; Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., van den Brink MRM; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Weill Cornell Medical College, New York, NY 10021, USA.; Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Ajami N; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Wargo JA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Reddy P; Department of Hematology and Oncology, University of Michigan, Ann Arbor, MI 48109, USA., Valdivia RH; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA., Davey L; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA., Rondon G; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Srour SA; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Mehta RS; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Alousi AM; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Shpall EJ; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Champlin RE; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Shelburne SA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Department of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Molldrem JJ; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Department of Hematopoietic Biology and Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Jamal MA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Karmouch JL; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Jenq RR; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; CPRIT Scholar in Cancer Research, Austin, TX 78701, USA.; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. |
| المصدر: | Science translational medicine [Sci Transl Med] 2022 Nov 16; Vol. 14 (671), pp. eabo3445. Date of Electronic Publication: 2022 Nov 16. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : American Association for the Advancement of Science |
| مواضيع طبية MeSH: | Gastrointestinal Microbiome* , Hematopoietic Stem Cell Transplantation* , Neutropenia*/metabolism , Neoplasms*/metabolism, Mice ; Animals ; Propionates ; Verrucomicrobia ; Mucus/metabolism ; Mucins/metabolism ; Diet |
| مستخلص: | Not all patients with cancer and severe neutropenia develop fever, and the fecal microbiome may play a role. In a single-center study of patients undergoing hematopoietic cell transplant ( n = 119), the fecal microbiome was characterized at onset of severe neutropenia. A total of 63 patients (53%) developed a subsequent fever, and their fecal microbiome displayed increased relative abundances of Akkermansia muciniphila , a species of mucin-degrading bacteria ( P = 0.006, corrected for multiple comparisons). Two therapies that induce neutropenia, irradiation and melphalan, similarly expanded A. muciniphila and additionally thinned the colonic mucus layer in mice. Caloric restriction of unirradiated mice also expanded A. muciniphila and thinned the colonic mucus layer. Antibiotic treatment to eradicate A. muciniphila before caloric restriction preserved colonic mucus, whereas A. muciniphila reintroduction restored mucus thinning. Caloric restriction of unirradiated mice raised colonic luminal pH and reduced acetate, propionate, and butyrate. Culturing A. muciniphila in vitro with propionate reduced utilization of mucin as well as of fucose. Treating irradiated mice with an antibiotic targeting A. muciniphila or propionate preserved the mucus layer, suppressed translocation of flagellin, reduced inflammatory cytokines in the colon, and improved thermoregulation. These results suggest that diet, metabolites, and colonic mucus link the microbiome to neutropenic fever and may guide future microbiome-based preventive strategies. |
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| معلومات مُعتمدة: | P30 CA016672 United States CA NCI NIH HHS; P01 CA023766 United States CA NCI NIH HHS; R01 CA228308 United States CA NCI NIH HHS; R01 HL147584 United States HL NHLBI NIH HHS; R01 HL124112 United States HL NHLBI NIH HHS; K01 AI143881 United States AI NIAID NIH HHS; P30 CA008748 United States CA NCI NIH HHS; K08 HL143189 United States HL NHLBI NIH HHS; R01 HL123340 United States HL NHLBI NIH HHS; S10 OD012304 United States OD NIH HHS; R01 CA228358 United States CA NCI NIH HHS |
| المشرفين على المادة: | 0 (Propionates) 0 (Mucins) |
| تواريخ الأحداث: | Date Created: 20221116 Date Completed: 20221118 Latest Revision: 20240719 |
| رمز التحديث: | 20240719 |
| مُعرف محوري في PubMed: | PMC10028729 |
| DOI: | 10.1126/scitranslmed.abo3445 |
| PMID: | 36383683 |
| قاعدة البيانات: | MEDLINE |
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