دورية أكاديمية
SARS-CoV-2 infected children form early immune memory responses dominated by nucleocapsid-specific CD8+ T cells and antibodies.
العنوان: | SARS-CoV-2 infected children form early immune memory responses dominated by nucleocapsid-specific CD8+ T cells and antibodies. |
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المؤلفون: | Lima K; Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA, Porto Alegre, Brazil., Fontoura JC; Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA, Porto Alegre, Brazil., de Souza PO; Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA, Porto Alegre, Brazil., Fazolo T; Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA, Porto Alegre, Brazil., Hilario G; Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA, Porto Alegre, Brazil., Zorzetto R; Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA, Porto Alegre, Brazil., Rodrigues Junior LC; Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA, Porto Alegre, Brazil., Coimbra LD; Brazilian Biosciences National Laboratory, Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, Brazil., Borin A; Brazilian Biosciences National Laboratory, Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, Brazil., Bispo-Dos-Santos K; Laboratory of Emerging Viruses (LEVE), Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (Unicamp), Campinas, Brazil., Granja F; Laboratory of Emerging Viruses (LEVE), Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (Unicamp), Campinas, Brazil.; Biodiversity Research Centre, Federal University of Roraima (UFRR), Boa Vista, Brazil., Marques RE; Brazilian Biosciences National Laboratory, Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, Brazil., Zavaglia GO; Social Responsibility - Programa de Apoio ao Desenvolvimento Institucional do Sistema Único de Saúde (PROADI-SUS ), Hospital Moinhos de Vento, Porto Alegre, Brazil., Fernandes IR; Social Responsibility - Programa de Apoio ao Desenvolvimento Institucional do Sistema Único de Saúde (PROADI-SUS ), Hospital Moinhos de Vento, Porto Alegre, Brazil., Varela FH; Social Responsibility - Programa de Apoio ao Desenvolvimento Institucional do Sistema Único de Saúde (PROADI-SUS ), Hospital Moinhos de Vento, Porto Alegre, Brazil., Polese-Bonatto M; Social Responsibility - Programa de Apoio ao Desenvolvimento Institucional do Sistema Único de Saúde (PROADI-SUS ), Hospital Moinhos de Vento, Porto Alegre, Brazil., Tonini ML; Coordenação-Geral de Vigilância das Doenças de Transmissão Respiratória de Condições Crônicas, Departamento de Doenças de Condições Crônicas e IST, Secretaria de Vigilância em Saúde - Ministério da Saúde (CGDR/DCCI/SVS/MS)., Brasília, Brazil., Ikeda do Carmo GM; Departamento de Imunizações e doenças transmissíveis, Secretaria de Vigilância em Saúde - Ministério da Saúde (DEIDT/SVS/MS), Brasília, Brazil., de Almeida WAF; Departamento de Imunizações e doenças transmissíveis, Secretaria de Vigilância em Saúde - Ministério da Saúde (DEIDT/SVS/MS), Brasília, Brazil., Borges TJ; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Nakaya HI; Computational System Biology Laboratory (CSBL), Hospital Israelita Albert Einstein, São Paulo, Brazil., Proenca-Modena JL; Laboratory of Emerging Viruses (LEVE), Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (Unicamp), Campinas, Brazil.; Hub of Global Health (HGH), University of Campinas (Unicamp), Campinas, Brazil., Callegari-Jacques SM; Departamento de Estatística, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Scotta MC; Social Responsibility - Programa de Apoio ao Desenvolvimento Institucional do Sistema Único de Saúde (PROADI-SUS ), Hospital Moinhos de Vento, Porto Alegre, Brazil.; Escola de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul - PUCRS, Porto Alegre, Brazil., Stein RT; Social Responsibility - Programa de Apoio ao Desenvolvimento Institucional do Sistema Único de Saúde (PROADI-SUS ), Hospital Moinhos de Vento, Porto Alegre, Brazil.; Escola de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul - PUCRS, Porto Alegre, Brazil., Bonorino C; Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA, Porto Alegre, Brazil.; Department of Surgery, University of California at San Diego - UCSD, La Jolla, CA, United States. |
المصدر: | Frontiers in immunology [Front Immunol] 2022 Nov 02; Vol. 13, pp. 1033364. Date of Electronic Publication: 2022 Nov 02 (Print Publication: 2022). |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
مواضيع طبية MeSH: | SARS-CoV-2* , COVID-19*, Humans ; Adult ; Child ; Immunologic Memory ; CD8-Positive T-Lymphocytes ; Nucleocapsid ; Antibodies |
مستخلص: | This is the third year of the SARS-CoV-2 pandemic, and yet most children remain unvaccinated. COVID-19 in children manifests as mostly mild or asymptomatic, however high viral titers and strong cellular and humoral responses are observed upon acute infection. It is still unclear how long these responses persist, and if they can protect from re-infection and/or disease severity. Here, we analyzed immune memory responses in a cohort of children and adults with COVID-19. Important differences between children and adults are evident in kinetics and profile of memory responses. Children develop early N-specific cytotoxic T cell responses, that rapidly expand and dominate their immune memory to the virus. Children's anti-N, but not anti-S, antibody titers increase over time. Neutralization titers correlate with N-specific antibodies and CD8 + T cells. However, antibodies generated by infection do not efficiently cross-neutralize variants Gamma or Delta. Our results indicate that mechanisms that protect from disease severity are possibly different from those that protect from reinfection, bringing novel insights for pediatric vaccine design. They also underline the importance of vaccination in children, who remain at risk for COVID-19 despite having been previously infected. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Lima, Fontoura, de Souza, Fazolo, Hilario, Zorzetto, Rodrigues Junior, Coimbra, Borin, Bispo-dos-Santos, Granja, Marques, Zavaglia, Fernandes, Varela, Polese-Bonatto, Tonini, Ikeda do Carmo, de Almeida, Borges, Nakaya, Proenca-Modena, Callegari-Jacques, Scotta, Stein and Bonorino.) |
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فهرسة مساهمة: | Keywords: COVID-19; Memory T cell; N protein; antibodies; neutralizing antibodies; variants of concern |
المشرفين على المادة: | 0 (Antibodies) |
تواريخ الأحداث: | Date Created: 20221121 Date Completed: 20221122 Latest Revision: 20221122 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC9667737 |
DOI: | 10.3389/fimmu.2022.1033364 |
PMID: | 36405692 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1664-3224 |
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DOI: | 10.3389/fimmu.2022.1033364 |