دورية أكاديمية
Lisinopril-Induced Small Bowel Angioedema: An Unusual Cause of Severe Abdominal Pain.
| العنوان: | Lisinopril-Induced Small Bowel Angioedema: An Unusual Cause of Severe Abdominal Pain. |
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| المؤلفون: | Johnson BW; Department of Anesthesiology, Mayo Clinic, Phoenix, AZ, USA., Rydburg AM; Medical Student, Mayo Clinic Alix School of Medicine, Phoenix, AZ, USA., Do VD; Department of Hospital Internal Medicine, Mayo Clinic, Phoenix, AZ, USA. |
| المصدر: | The American journal of case reports [Am J Case Rep] 2022 Nov 22; Vol. 23, pp. e937895. Date of Electronic Publication: 2022 Nov 22. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: International Scientific Information, Inc Country of Publication: United States NLM ID: 101489566 Publication Model: Electronic Cited Medium: Internet ISSN: 1941-5923 (Electronic) Linking ISSN: 19415923 NLM ISO Abbreviation: Am J Case Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2014- > : Smithtown, NY : International Scientific Information, Inc. Original Publication: Albertson, NY : International Scientific Literature, Inc. |
| مواضيع طبية MeSH: | Lisinopril*/adverse effects , Angioedema*/chemically induced , Angioedema*/diagnosis, Female ; Humans ; Middle Aged ; Abdominal Pain/chemically induced ; Abdominal Pain/diagnosis ; Angiotensin-Converting Enzyme Inhibitors/adverse effects ; Abdomen |
| مستخلص: | BACKGROUND Angiotensin-converting enzyme inhibitors (ACE-I) are one of the most frequently prescribed classes of medications with the rare adverse effect of angioedema, and isolated small bowel angioedema is a small subset of these cases. Isolated angioedema of the small bowel is a rare adverse effect of this commonly prescribed medication, and it mimics, symptomatically and radiographically, several other illnesses and is often misdiagnosed. While ACE-I are thought to be safe, the risk of angioedema is approximately 0.7%. Isolated small bowel angioedema is often not diagnosed in a timely manner, and misdiagnosis leads to significant morbidity in afflicted patients. CASE REPORT We present the case of a 63-year-old woman with angioedema of the small bowel causing abdominal pain, nausea, vomiting, and diarrhea. Computed tomography demonstrated small bowel edema and ascites. The patient had been taking lisinopril for 7 years prior to presentation and had previously been seen by multiple physicians for abdominal pain. A diagnosis of ACE-I-induced small bowel angioedema was made and lisinopril therapy was immediately stopped. Her symptoms improved with cessation of lisinopril, and follow-up imaging showed resolution of the angioedema 3 months later. CONCLUSIONS The course of ACE-I-induced angioedema is unpredictable and often overlooked as a cause of abdominal pain. It commonly presents soon after starting ACE-I therapy, but can present years after therapy initiation, as in this case. Significant morbidity, including unnecessary exploratory laparotomy, is associated with misdiagnosis of ACE-I-induced angioedema of the small bowel. Prompt recognition and cessation of the offending drug is crucial but often delayed. |
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| المشرفين على المادة: | E7199S1YWR (Lisinopril) 0 (Angiotensin-Converting Enzyme Inhibitors) |
| تواريخ الأحداث: | Date Created: 20221122 Date Completed: 20221124 Latest Revision: 20221209 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC9701529 |
| DOI: | 10.12659/AJCR.937895 |
| PMID: | 36413511 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1941-5923 |
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| DOI: | 10.12659/AJCR.937895 |