دورية أكاديمية
أعرض في EDS

Depressive and Insomnia Symptoms Sequentially Mediate the Association Between Racism-Based Discrimination in Healthcare Settings and Clinical Pain Among Adults With Sickle Cell Disease.

التفاصيل البيبلوغرافية
العنوان: Depressive and Insomnia Symptoms Sequentially Mediate the Association Between Racism-Based Discrimination in Healthcare Settings and Clinical Pain Among Adults With Sickle Cell Disease.
المؤلفون: McGill LS; Department of Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine, Baltimore, Maryland. Electronic address: lmcgill3@jhmi.edu., Hamilton KR; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland., Letzen JE; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland., Finan PH; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland., Lanzkron SM; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland., Smith MT; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland., Haythornthwaite JA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland., Campbell CM; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland.
المصدر: The journal of pain [J Pain] 2023 Apr; Vol. 24 (4), pp. 643-654. Date of Electronic Publication: 2022 Nov 20.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Churchill Livingstone Country of Publication: United States NLM ID: 100898657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-8447 (Electronic) Linking ISSN: 15265900 NLM ISO Abbreviation: J Pain Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Philadelphia, PA : Churchill Livingstone, c2000-
مواضيع طبية MeSH: Sleep Initiation and Maintenance Disorders*/etiology , Racism* , Anemia, Sickle Cell*/complications, Humans ; Adult ; Female ; Male ; Pain/etiology ; Depression/complications ; Delivery of Health Care
مستخلص: Racism-based discrimination in healthcare settings has been associated with clinical pain in adults living with sickle cell disease; however, no studies have examined depressive and insomnia symptoms as mechanisms that may drive this relationship. This secondary data analysis examined associations between depressive and insomnia symptoms, racism-based discrimination, and clinical pain. Seventy-one adults with sickle cell disease (70% female, M age  = 38.79) provided baseline reports of racism-based discrimination, depressive symptoms, insomnia symptoms, and pain (severity, interference, catastrophizing), and they completed daily diaries of pain severity and interference over 3 months. In a sequential mediation model, baseline depressive (1st) and insomnia symptoms (2nd) significantly mediated the association between racism-based discrimination and baseline pain interference, average daily diary pain severity, and average daily diary pain interference. Although the mediation model with baseline pain severity as the outcome was significant, the total and direct effects were not. Results indicate that discrimination in healthcare settings contributes to depression, which may act on pain through sleep disturbance. Findings support the need for systemic and structural changes to eliminate discrimination in healthcare settings and behavioral mood and sleep interventions to reduce the impact of discrimination on clinical pain. PERSPECTIVE: The relationship between discrimination in healthcare settings and pain in adults with sickle cell disease may be driven by depression and sleep disturbance, modifiable risk factors and potential treatment targets. Results suggest that systemic, structural, and institutional changes must be implemented to promote better patient care and health outcomes.
(Copyright © 2022 United States Association for the Study of Pain, Inc. Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: T32 NS070201 United States NS NINDS NIH HHS; R01 HL098110 United States HL NHLBI NIH HHS; R01 HL133327 United States HL NHLBI NIH HHS; K23 NS124935 United States NS NINDS NIH HHS; T32 HD007414 United States HD NICHD NIH HHS; K24 AR081143 United States AR NIAMS NIH HHS
فهرسة مساهمة: Keywords: Sickle cell disease; depression; discrimination; pain; sleep
تواريخ الأحداث: Date Created: 20221122 Date Completed: 20230410 Latest Revision: 20240402
رمز التحديث: 20240402
مُعرف محوري في PubMed: PMC10079566
DOI: 10.1016/j.jpain.2022.11.004
PMID: 36414154
قاعدة البيانات: MEDLINE
الوصف
تدمد:1528-8447
DOI:10.1016/j.jpain.2022.11.004