دورية أكاديمية
IFITM proteins: Understanding their diverse roles in viral infection, cancer, and immunity.
| العنوان: | IFITM proteins: Understanding their diverse roles in viral infection, cancer, and immunity. |
|---|---|
| المؤلفون: | Gómez-Herranz M; International Centre for Cancer Vaccine Science, University of Gdańsk, Poland; Institute of Genetics and Cancer (IGC), University of Edinburgh, Edinburgh, United Kingdom. Electronic address: maria.gomez@ug.edu.pl., Taylor J; Institute of Genetics and Cancer (IGC), University of Edinburgh, Edinburgh, United Kingdom; Infection Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom., Sloan RD; Infection Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom; ZJU-UoE Institute, Zhejiang University, Haining, Zhejiang, China. Electronic address: richard.sloan@ed.ac.uk. |
| المصدر: | The Journal of biological chemistry [J Biol Chem] 2023 Jan; Vol. 299 (1), pp. 102741. Date of Electronic Publication: 2022 Nov 23. |
| نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [New York, NY] : Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Original Publication: Baltimore, MD : American Society for Biochemistry and Molecular Biology |
| مواضيع طبية MeSH: | Virus Diseases*/genetics , Neoplasms*/genetics, Humans ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Virus Internalization ; Antiviral Agents ; Antigens, Differentiation/genetics ; Antigens, Differentiation/metabolism |
| مستخلص: | Interferon-induced transmembrane proteins (IFITMs) are broad spectrum antiviral factors that inhibit the entry of a wide range of clinically important pathogens including influenza A virus, HIV-1, and Dengue virus. IFITMs are thought to act primarily by antagonizing virus-cell membrane fusion in this regard. However, recent work on these proteins has uncovered novel post-entry viral restriction mechanisms. IFITMs are also increasingly thought to have a role regulating immune responses, including innate antiviral and inflammatory responses as well as adaptive T-cell and B-cell responses. Further, IFITMs may have pathological activities in cancer, wherein IFITM expression can be a marker of therapeutically resistant and aggressive disease courses. In this review, we summarize the respective literatures concerning these apparently diverse functions with a view to identifying common themes and potentially yielding a more unified understanding of IFITM biology. Competing Interests: Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article. (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.) |
| معلومات مُعتمدة: | MR/N013166/1 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: IFITM; IFITM1; IFITM2; IFITM3; IFITMs; antiviral factors; cancer; innate immunity; interferon; restriction factors; translation |
| المشرفين على المادة: | 0 (Membrane Proteins) 0 (Antiviral Agents) 0 (Antigens, Differentiation) |
| تواريخ الأحداث: | Date Created: 20221126 Date Completed: 20230127 Latest Revision: 20230202 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9800550 |
| DOI: | 10.1016/j.jbc.2022.102741 |
| PMID: | 36435199 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1083-351X |
|---|---|
| DOI: | 10.1016/j.jbc.2022.102741 |