دورية أكاديمية
أعرض في EDS

Pathogen and Antibody Identification in Children with Encephalitis in Myanmar.

التفاصيل البيبلوغرافية
العنوان: Pathogen and Antibody Identification in Children with Encephalitis in Myanmar.
المؤلفون: Galardi MM; Department of Neurology, Washington University School of Medicine, St. Louis, MO., Sowa GM; Department of Medicine, McGaw Medical Center of Northwestern University, Chicago, IL., Crockett CD; Department of Neurology, Washington University School of Medicine, St. Louis, MO., Rudock R; Department of Neurology, Washington University School of Medicine, St. Louis, MO., Smith AE; Department of Neurology, Washington University School of Medicine, St. Louis, MO., Shwe EE; Department of Pathology, Yangon Children's Hospital, Institute of Medicine 1, Yangon, Myanmar., San T; Department of Pathology, Yangon Children's Hospital, Institute of Medicine 1, Yangon, Myanmar., Linn K; Department of Pediatrics, Yangon Children's Hospital, Institute of Medicine 1, Yangon, Myanmar., Aye AMM; Department of Pediatrics, Yangon Children's Hospital, Institute of Medicine 1, Yangon, Myanmar., Ramachandran PS; Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA., Zia M; Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA., Wapniarski AE; Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA., Hawes IA; Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA., Hlaing CS; Department of Pediatrics, Yangon Children's Hospital, Institute of Medicine 1, Yangon, Myanmar., Kyu EH; Department of Pediatrics, Yangon Children's Hospital, Institute of Medicine 1, Yangon, Myanmar., Thair C; Department of Pediatrics, Yangon Children's Hospital, Institute of Medicine 1, Yangon, Myanmar., Mar YY; Department of Pediatrics, Yangon Children's Hospital, Institute of Medicine 1, Yangon, Myanmar., Nway N; Department of Pediatrics, Yangon Children's Hospital, Institute of Medicine 1, Yangon, Myanmar., Storch GA; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO., Wylie KM; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO., Wylie TN; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO., Dalmau J; Neuroimmunology Program, Institut d'Investigacions Biomèdiques August Pi i Sunyer Hospital Clínic, University of Barcelona, Barcelona, Spain.; Department of Neurology, University of Pennsylvania, Philadelphia, PA.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain., Wilson MR; Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA., Mar SS; Department of Neurology, Washington University School of Medicine, St. Louis, MO.
المصدر: Annals of neurology [Ann Neurol] 2023 Mar; Vol. 93 (3), pp. 615-628. Date of Electronic Publication: 2022 Dec 12.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7707449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8249 (Electronic) Linking ISSN: 03645134 NLM ISO Abbreviation: Ann Neurol Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Wiley-Liss
Original Publication: Boston, Little, Brown.
مواضيع طبية MeSH: Meningitis*/cerebrospinal fluid , Meningitis*/diagnosis , Encephalitis*/cerebrospinal fluid , Communicable Diseases* , Infectious Encephalitis* , Autoimmune Diseases of the Nervous System*, Child ; Humans ; Prospective Studies ; Myanmar
مستخلص: Objective: Prospective studies of encephalitis are rare in regions where encephalitis is prevalent, such as low middle-income Southeast Asian countries. We compared the diagnostic yield of local and advanced tests in cases of pediatric encephalitis in Myanmar.
Methods: Children with suspected subacute or acute encephalitis at Yangon Children's Hospital, Yangon, Myanmar, were prospectively recruited from 2016-2018. Cohort 1 (n = 65) had locally available diagnostic testing, whereas cohort 2 (n = 38) had advanced tests for autoantibodies (ie, cell-based assays, tissue immunostaining, studies with cultured neurons) and infections (ie, BioFire FilmArray multiplex Meningitis/Encephalitis multiplex PCR panel, metagenomic sequencing, and pan-viral serologic testing [VirScan] of cerebrospinal fluid).
Results: A total of 20 cases (13 in cohort 1 and 7 in cohort 2) were found to have illnesses other than encephalitis. Of the 52 remaining cases in cohort 1, 43 (83%) had presumed infectious encephalitis, of which 2 cases (4%) had a confirmed infectious etiology. Nine cases (17%) had presumed autoimmune encephalitis. Of the 31 cases in cohort 2, 23 (74%) had presumed infectious encephalitis, of which one (3%) had confirmed infectious etiology using local tests only, whereas 8 (26%) had presumed autoimmune encephalitis. Advanced tests confirmed an additional 10 (32%) infections, 4 (13%) possible infections, and 5 (16%) cases of N-methyl-D-aspartate receptor antibody encephalitis.
Interpretation: Pediatric encephalitis is prevalent in Myanmar, and advanced technologies increase identification of treatable infectious and autoimmune causes. Developing affordable advanced tests to use globally represents a high clinical and research priority to improve the diagnosis and prognosis of encephalitis. ANN NEUROL 2023;93:615-628.
(© 2022 American Neurological Association.)
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معلومات مُعتمدة: K08 NS096117 United States NS NINDS NIH HHS
SCR Disease Name: Hashimoto's encephalitis
تواريخ الأحداث: Date Created: 20221129 Date Completed: 20230227 Latest Revision: 20230329
رمز التحديث: 20230329
DOI: 10.1002/ana.26560
PMID: 36443898
قاعدة البيانات: MEDLINE
الوصف
تدمد:1531-8249
DOI:10.1002/ana.26560