دورية أكاديمية
أعرض في EDS

Palliated Hypoplastic Left Heart Syndrome Patients Experience Superior Waitlist and Comparable Post-Heart Transplant Survival to Non-Single Ventricle Congenital Heart Disease Patients.

التفاصيل البيبلوغرافية
العنوان: Palliated Hypoplastic Left Heart Syndrome Patients Experience Superior Waitlist and Comparable Post-Heart Transplant Survival to Non-Single Ventricle Congenital Heart Disease Patients.
المؤلفون: Greenberg JW; The Heart Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address: jasongreenbergmd@gmail.com., Raees MA; The Heart Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio., Dani A; The Heart Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio., Heydarian HC; The Heart Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio., Chin C; The Heart Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio., Zafar F; The Heart Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio., Lehenbauer DG; The Heart Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio., Morales DLS; The Heart Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
المصدر: Seminars in thoracic and cardiovascular surgery [Semin Thorac Cardiovasc Surg] 2024 Summer; Vol. 36 (2), pp. 230-241. Date of Electronic Publication: 2022 Nov 29.
نوع المنشور: Journal Article; Comparative Study
اللغة: English
بيانات الدورية: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 8917640 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-9488 (Electronic) Linking ISSN: 10430679 NLM ISO Abbreviation: Semin Thorac Cardiovasc Surg Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Philadelphia, PA] : W.B. Saunders, [c1989-
مواضيع طبية MeSH: Heart Transplantation*/mortality , Heart Transplantation*/adverse effects , Waiting Lists*/mortality , Hypoplastic Left Heart Syndrome*/surgery , Hypoplastic Left Heart Syndrome*/mortality , Hypoplastic Left Heart Syndrome*/physiopathology , Palliative Care*, Humans ; Male ; Female ; Time Factors ; Risk Factors ; Infant ; Treatment Outcome ; Child, Preschool ; Retrospective Studies ; United States ; Risk Assessment ; Heart Defects, Congenital/surgery ; Heart Defects, Congenital/mortality ; Heart Defects, Congenital/physiopathology ; Child ; Infant, Newborn ; Databases, Factual ; Adolescent
مستخلص: Congenital heart disease (CHD) is a well-established risk factor for inferior waitlist and post-heart transplant survival in children. Differences in outcomes between CHD subgroups are understudied. The present study compared outcomes for palliated hypoplastic left heart syndrome (HLHS) patients to other non-single ventricle CHD (non-SVCHD) and non-CHD patients. United Network for Organ Sharing was used to identify children (age < 18) listed for heart transplant in the United States between 2016 and 2021. CHD sub-diagnoses were only available for United Network for Organ Sharing status 1a after 2015, thereby defining the cohort. Waitlist outcomes were studied using competing-risk time-to-event analysis for transplantation, mortality/decompensation, and alive-on-waitlist. Multivariable Cox proportional hazards regression analyses were used to identify factors associated with inferior post-transplant survival. Patients included: palliated-HLHS (n = 477), non-SVCHD (n = 686), and non-CHD (n = 1261). At listing, Palliated-HLHS patients were older than non-SVCHD (median 2-year [IQR 0-8] vs median 0-year [0-3], respectively) and younger than non-CHD (median 7-year [0-14]) (P < 0.001 vs both), and were more likely to be white (P < 0.01 vs both). Upon time-to-event analysis, rates of waitlist mortality/decompensation rates were greater among non-SVCHD than palliated-HLHS. Post-transplant survival was comparable between palliated-HLHS and non-SVCHD (P = 0.920) but worse compared to non-CHD (P < 0.001). Both palliated-HLHS (HR 2.40 [95% CI 1.68-3.42]) and non-SVSCHD (2.04 [1.39-2.99]) were independently associated with post-transplant mortality. Palliated-HLHS patients with heart failure experience significantly worse post-transplant outcomes than non-CHD but, compared to other CHD patients, experience superior waitlist and comparable post-transplant survival. While a high-risk cohort, HLHS patients can achieve gratifying waitlist and post-transplant survival.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
References: Front Pediatr. 2021 Jul 06;9:635776. (PMID: 34295856)
Circulation. 2002 Sep 24;106(12 Suppl 1):I82-9. (PMID: 12354714)
Pediatr Transplant. 2020 May;24(3):e13671. (PMID: 32198830)
J Thorac Cardiovasc Surg. 2010 Jan;139(1):119-26; discussion 126-7. (PMID: 19909991)
Circulation. 2016 Jul 12;134(2):101-9. (PMID: 27382105)
ASAIO J. 2021 Sep 1;67(9):1051-1059. (PMID: 33181541)
Pediatr Nephrol. 2010 Nov;25(11):2321-6. (PMID: 20652327)
Circulation. 2016 Oct 25;134(17):1265-1279. (PMID: 27777296)
Ann Thorac Surg. 2021 Dec;112(6):1763-1774. (PMID: 34648810)
Circulation. 2016 Jul 12;134(2):110-3. (PMID: 27382106)
J Thorac Cardiovasc Surg. 2020 Jun;159(6):2418-2425.e1. (PMID: 31839235)
Circulation. 2007 Feb 6;115(5):658-76. (PMID: 17261651)
Eur J Cardiothorac Surg. 2015 Nov;48(5):792-8; discussion 798-9. (PMID: 25602055)
J Am Coll Cardiol. 2009 Jul 7;54(2):160-5. (PMID: 19573734)
Eur J Cardiothorac Surg. 2013 Mar;43(3):597-603. (PMID: 22761500)
Transl Pediatr. 2018 Apr;7(2):151-161. (PMID: 29770296)
J Am Coll Cardiol. 2012 Jan 3;59(1 Suppl):S1-42. (PMID: 22192720)
Circ Res. 2017 Mar 17;120(6):978-994. (PMID: 28302743)
Am J Transplant. 2012 May;12(5):1240-8. (PMID: 22300640)
Ann Thorac Surg. 2012 Sep;94(3):807-15; discussion 815-6. (PMID: 22632881)
Cardiol Young. 2018 Nov;28(11):1275-1288. (PMID: 30223915)
Circulation. 2018 May 22;137(21):2246-2253. (PMID: 29437119)
J Heart Lung Transplant. 2009 Dec;28(12):1292-8. (PMID: 19782580)
J Pediatr. 2008 Dec;153(6):807-13. (PMID: 18657826)
Circulation. 2010 Feb 9;121(5):644-50. (PMID: 20100974)
J Heart Lung Transplant. 2012 Jun;31(6):591-600. (PMID: 22458996)
World J Pediatr Congenit Heart Surg. 2021 May;12(3):352-359. (PMID: 33942695)
Ann Thorac Surg. 2011 Apr;91(4):1248-54; discussion 1254-5. (PMID: 21440154)
J Heart Lung Transplant. 2021 Aug;40(8):709-732. (PMID: 34193359)
J Thorac Cardiovasc Surg. 2015 Dec;150(6):1455-62.e3. (PMID: 26190654)
معلومات مُعتمدة: R01 HL147957 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: Clinical outcomes; Congenital cardiac surgery; Congenital heart disease; Heart transplantation; Hypoplastic left heart syndrome; Norwood procedure; Quality improvement
تواريخ الأحداث: Date Created: 20221201 Date Completed: 20240530 Latest Revision: 20240601
رمز التحديث: 20240601
مُعرف محوري في PubMed: PMC10225473
DOI: 10.1053/j.semtcvs.2022.08.019
PMID: 36455711
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-9488
DOI:10.1053/j.semtcvs.2022.08.019