دورية أكاديمية
Bisphosphonate-loaded bone cement: Background, clinical indications and future perspectives.
| العنوان: | Bisphosphonate-loaded bone cement: Background, clinical indications and future perspectives. |
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| المؤلفون: | Zogakis PN; Laboratory for Research of the Musculoskeletal System 'Th. Garofalidis', Medical School, National and Kapodistrian University of Athens, KAT General Hospital of Athens, Greece.; 1st Department of Orthopaedics, General Children's Hospital 'Aghia Sofia', Athens, Greece., Teles AR; Neurosurgery and Spine Program, Hospital Beneficente São Carlos, Farroupilha-RS, Brazil McGill Scoliosis and Spine Group, Montreal-QC, Canada., Zafeiris ΕP; 2nd Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece., Zafeiris CP; Laboratory for Research of the Musculoskeletal System 'Th. Garofalidis', Medical School, National and Kapodistrian University of Athens, KAT General Hospital of Athens, Greece. |
| المصدر: | Journal of musculoskeletal & neuronal interactions [J Musculoskelet Neuronal Interact] 2022 Dec 01; Vol. 22 (4), pp. 587-595. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: International Society of Musculoskeletal and Neuronal Interactions Country of Publication: Greece NLM ID: 101084496 Publication Model: Print Cited Medium: Internet ISSN: 1108-7161 (Print) Linking ISSN: 11087161 NLM ISO Abbreviation: J Musculoskelet Neuronal Interact Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kifissia, Greece : International Society of Musculoskeletal and Neuronal Interactions, 2000- |
| مواضيع طبية MeSH: | Bone Resorption* , Orthopedic Procedures*, Humans ; Bone Cements ; Diphosphonates/pharmacology ; Zoledronic Acid |
| مستخلص: | Bisphosphonates represent an established treatment against bone resorption and osseous loss. Local application could help increase bone mineral density while minimizing their systemic use side-effects. Bone cement, used on a large scale in orthopedic surgery and a historically successful drug carrier, could represent an effective scaffold. The aim of this review was to investigate the alterations produced on the cement's structure and properties by this mixture, as well as its antiosteoporotic and antitumor effect. After a thorough research of articles, title screening and duplicate removal we retained 51 papers. Two independent authors performed abstract and full-text reading, finally leaving 35 articles included in this review. In the current literature, acrylic and calcium phosphate bone cement have been used as carriers. A combination with nitrogen-containing bisphosphonates, e.g., zoledronic acid, provokes modifications in terms of setting time prolongation and mechanical strength decline within acceptable levels, on the condition that the drug's quantity stays beneath a certain plateau. Bisphosphonates in bone cement seem to have a powerful anti-osteoclastic and osteogenic local impact as well as a direct cytotoxic effect against several neoplastic lesions. Further investigation on the subject is required, with specifically designed studies focusing on this method's advantages and potential clinical applications. Competing Interests: The authors have no conflict of interest. |
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| فهرسة مساهمة: | Keywords: Bisphosphonates; Bone Cement; Bone Regeneration; Osteolysis; Osteoporosis |
| المشرفين على المادة: | 0 (Bone Cements) 0 (Diphosphonates) 6XC1PAD3KF (Zoledronic Acid) |
| تواريخ الأحداث: | Date Created: 20221202 Date Completed: 20221205 Latest Revision: 20221230 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC9716296 |
| PMID: | 36458394 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1108-7161 |
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