دورية أكاديمية
أعرض في EDS

Evaluation of corneal epithelial thickness mapping using anterior segment OCT in children with vernal keratoconjunctivitis.

التفاصيل البيبلوغرافية
العنوان: Evaluation of corneal epithelial thickness mapping using anterior segment OCT in children with vernal keratoconjunctivitis.
المؤلفون: Albadawi MA; Faculty of Medicine, Cairo University, Manial, Cairo, 1107, Egypt., Nassar GA; Faculty of Medicine, Cairo University, Manial, Cairo, 1107, Egypt., El Gendy HA; Faculty of Medicine, Cairo University, Manial, Cairo, 1107, Egypt. heba.elgendy@kasralainy.edu.eg., Ghalwash DA; Faculty of Medicine, Cairo University, Manial, Cairo, 1107, Egypt.
المصدر: International ophthalmology [Int Ophthalmol] 2023 Jun; Vol. 43 (6), pp. 1967-1976. Date of Electronic Publication: 2022 Dec 03.
نوع المنشور: Observational Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: Kluwer Country of Publication: Netherlands NLM ID: 7904294 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2630 (Electronic) Linking ISSN: 01655701 NLM ISO Abbreviation: Int Ophthalmol Subsets: MEDLINE
أسماء مطبوعة: Publication: Dordrecht : Kluwer
Original Publication: The Hague, Junk.
مواضيع طبية MeSH: Conjunctivitis, Allergic*/diagnosis, Humans ; Tomography, Optical Coherence ; Cross-Sectional Studies ; Cornea ; Eyelids
مستخلص: Purpose: To evaluate the corneal epithelial thickness by anterior segment OCT in children with vernal keratoconjunctivitis (VKC) compared to normal participants.
Patient and Methods: A cross-sectional case control observational study was conducted on children aged from 5 to 18 years with VKC. The study included 142 eyes divided into two groups: 71 eyes of VKC group and 71 eyes of age matched control group. Anterior segment OCT epithelial mapping for the central 5-mm was done to evaluate epithelial thickness-based variables.
Results: Corneal epithelial thickness mapping showed significant superior thinning (51.07 ± 4.11) μm in VKC group compared to controls (52.54 ± 2.01) μm (p = 0.008), a decreased MIN epithelial thickness (45.99 ± 6.52) μm compared to controls (50.11 ± 1.91) μm (p < 0.001) and more negative (MIN-MAX) value (- 11.77 ± 9.38) indicating focal epithelial thinning compared to (- 5.80 ± 1.88) in controls (p = 0.001). In palpebral VKC, MIN epithelial thickness showed significant thinning (48. 38 ± 3.45) μm compared to controls (50.11 ± 1.91) μm (p = 0.001). Eyes with mixed VKC showed superior epithelial thinning (50.70 ± 4.59) μm compared to (52.54 ± 2.01) μm in controls (p = 0.025) and significant decreased MIN epithelial thickness (43.78 ± 7.83) μm compared to (50.11 ± 1.91) μm in control group.
Conclusions: VKC is a disease primarily affecting the corneal epithelium. Corneal epithelial thickness mapping may be considered to assess the integrity of the ocular surface in eyes with VKC, and to detect corneal epithelial changes. Disease phenotype may influence the corneal epithelial changes, and the disease duration is another factor influencing these changes.
(© 2022. The Author(s).)
References: Arq Bras Oftalmol. 2005 Sep-Oct;68(5):593-8. (PMID: 16322853)
Ophthalmology. 2002 Nov;109(11):2018-23. (PMID: 12414408)
Am J Ophthalmol. 2016 Dec;172:64-71. (PMID: 27640005)
Community Eye Health. 2005 Mar;18(53):76-8. (PMID: 17491748)
Allergy. 2012 Nov;67(11):1327-37. (PMID: 22947083)
Ophthalmology. 2001 Apr;108(4):824-7. (PMID: 11305286)
Cont Lens Anterior Eye. 2015 Dec;38(6):461-5. (PMID: 26070227)
J Cataract Refract Surg. 2016 Feb;42(2):284-95. (PMID: 27026454)
فهرسة مساهمة: Keywords: Allergic conjunctivitis; Anterior segment OCT; Corneal epithelial thickness mapping; Vernal keratoconjunctivitis
تواريخ الأحداث: Date Created: 20221203 Date Completed: 20230524 Latest Revision: 20230525
رمز التحديث: 20230525
مُعرف محوري في PubMed: PMC10203025
DOI: 10.1007/s10792-022-02596-9
PMID: 36462126
قاعدة البيانات: MEDLINE
كن أول من يترك تعليقا!
يجب تسجيل دخولك أولا