دورية أكاديمية
[The p53 Tumor Suppressor and Copper Metabolism: An Unrevealed but Important Link].
| العنوان: | [The p53 Tumor Suppressor and Copper Metabolism: An Unrevealed but Important Link]. |
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| المؤلفون: | Tsymbal SA; ChemBio Cluster, University of Information Technology Mechanics and Optics (ITMO), Saint Petersburg, 197101 Russia.; zimbal@scamt-itmo.ru., Refeld AG; ChemBio Cluster, University of Information Technology Mechanics and Optics (ITMO), Saint Petersburg, 197101 Russia., Kuchur OA; ChemBio Cluster, University of Information Technology Mechanics and Optics (ITMO), Saint Petersburg, 197101 Russia. |
| المصدر: | Molekuliarnaia biologiia [Mol Biol (Mosk)] 2022 Nov-Dec; Vol. 56 (6), pp. 1057-1071. |
| نوع المنشور: | Review; English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Izdatelstvo Nauka Country of Publication: Russia (Federation) NLM ID: 0105454 Publication Model: Print Cited Medium: Print ISSN: 0026-8984 (Print) Linking ISSN: 00268984 NLM ISO Abbreviation: Mol Biol (Mosk) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moskva : Izdatelstvo Nauka |
| مواضيع طبية MeSH: | Tumor Suppressor Protein p53*/genetics , Copper*, Humans |
| مستخلص: | The balance of redox reactions and the fate of the tumor cell are closely related to the regulation of intracellular homeostasis of transition metals, among which copper and its compounds play a key role. Elevated levels of intracellular copper may be a cause and/or consequence of malignancy, since the metabolism of this metal affects the functioning of the electron transport chain, transcription regulation, cell growth, and migration. This wide range of actions is used in antitumor therapy: ROS generation and apoptosis mediated by copper addition, copper deprivation by chelators, and targeted inhibition of specific participants in the copper metabolism chain effectively reduce the survival of tumor cells. However, the exact mechanisms of influence on the cell cycle and cell death behind the activity of copper-associated drugs are still largely unexplored. Numerous attempts to identify them led to the identification of the induction of oxidative stress and the activation of apoptotic cascades via the p53 tumor suppressor, an integral attribute of the action of such compounds. At the same time, the influence of p53, apparently also extends onto the activity of copper metabolism proteins, mediating the processes of antioxidant protection and survival. More and more research data confirm that the interaction of copper and p53 is multifaceted and is not limited solely to ROS. The purpose of this review is to describe how p53 regulation is related to copper metabolic pathways and how this interaction can be used to improve the effectiveness of oncotherapy. |
| فهرسة مساهمة: | Keywords: Atox1; Ctr1; chemotherapy; copper metabolism; p53; reactive oxygen species; tumor therapy |
| المشرفين على المادة: | 0 (Tumor Suppressor Protein p53) 789U1901C5 (Copper) |
| تواريخ الأحداث: | Date Created: 20221207 Date Completed: 20221215 Latest Revision: 20221215 |
| رمز التحديث: | 20221215 |
| DOI: | 10.31857/S0026898422060222 |
| PMID: | 36475489 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0026-8984 |
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| DOI: | 10.31857/S0026898422060222 |