دورية أكاديمية
أعرض في EDS

Bioprospecting the American Alligator Peptidome for antiviral peptides against Venezuelan equine encephalitis virus.

التفاصيل البيبلوغرافية
العنوان: Bioprospecting the American Alligator Peptidome for antiviral peptides against Venezuelan equine encephalitis virus.
المؤلفون: Carfagno A; Department of Chemistry and Biochemistry, George Mason University, Manassas, Virginia, USA., Lin SC; School of Systems Biology, George Mason University, Manassas, Virginia, USA.; National Taiwan Ocean University, Keelung City, Taiwan., Chafran L; Department of Chemistry and Biochemistry, George Mason University, Manassas, Virginia, USA., Akhrymuk I; Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA., Callahan V; School of Systems Biology, George Mason University, Manassas, Virginia, USA., Po M; Department of Chemistry and Biochemistry, George Mason University, Manassas, Virginia, USA., Zhu Y; Department of Chemistry and Biochemistry, George Mason University, Manassas, Virginia, USA., Altalhi A; Department of Chemistry and Biochemistry, George Mason University, Manassas, Virginia, USA., Durkin DP; Chemistry Department, U.S. Naval Academy, Annapolis, Maryland, USA., Russo P; Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia, USA., Vliet KA; Department of Biology, University of Florida, Gainesville, Florida, USA., Webb-Robertson BJ; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA., Kehn-Hall K; Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.; Center for Emerging, Zoonotic, and Arthropod-borne Pathogens, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA., Bishop B; Department of Chemistry and Biochemistry, George Mason University, Manassas, Virginia, USA.
المصدر: Proteomics [Proteomics] 2023 Mar; Vol. 23 (5), pp. e2200237. Date of Electronic Publication: 2023 Jan 03.
نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101092707 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1615-9861 (Electronic) Linking ISSN: 16159853 NLM ISO Abbreviation: Proteomics Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim, Germany : Wiley-VCH,
مواضيع طبية MeSH: Encephalitis Virus, Venezuelan Equine*/physiology , Encephalomyelitis, Venezuelan Equine*/drug therapy , Encephalomyelitis, Venezuelan Equine*/prevention & control , Alligators and Crocodiles*, Animals ; Horses ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Bioprospecting ; Virus Replication ; Peptides
مستخلص: The innate immune protection provided by cationic antimicrobial peptides (CAMPs) has been shown to extend to antiviral activity, with putative mechanisms of action including direct interaction with host cells or pathogen membranes. The lack of therapeutics available for the treatment of viruses such as Venezuelan equine encephalitis virus (VEEV) underscores the urgency of novel strategies for antiviral discovery. American alligator plasma has been shown to exhibit strong in vitro antibacterial activity, and functionalized hydrogel particles have been successfully employed for the identification of specific CAMPs from alligator plasma. Here, a novel bait strategy in which particles were encapsulated in membranes from either healthy or VEEV-infected cells was implemented to identify peptides preferentially targeting infected cells for subsequent evaluation of antiviral activity. Statistical analysis of peptide identification results was used to select five candidate peptides for testing, of which one exhibited a dose-dependent inhibition of VEEV and also significantly inhibited infectious titers. Results suggest our bioprospecting strategy provides a versatile platform that may be adapted for antiviral peptide identification from complex biological samples.
(© 2023 Wiley-VCH GmbH.)
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فهرسة مساهمة: Keywords: Venezuelan equine encephalitis virus; antiviral peptides; mass spectrometry; membrane-encapsulated particles; non-model organism
المشرفين على المادة: 0 (Antiviral Agents)
0 (Peptides)
تواريخ الأحداث: Date Created: 20221208 Date Completed: 20230303 Latest Revision: 20230306
رمز التحديث: 20231215
DOI: 10.1002/pmic.202200237
PMID: 36480152
قاعدة البيانات: MEDLINE
الوصف
تدمد:1615-9861
DOI:10.1002/pmic.202200237