دورية أكاديمية
أعرض في EDS

Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation.

التفاصيل البيبلوغرافية
العنوان: Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation.
المؤلفون: Meagher M; Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA., Myasnikov A; Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA., Enemark EJ; Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, AR 72205, USA.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2022 Nov 24; Vol. 23 (23). Date of Electronic Publication: 2022 Nov 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Archaeal Proteins*/genetics , Archaeal Proteins*/metabolism , Sulfolobus solfataricus*/genetics , Sulfolobus solfataricus*/metabolism , DNA Helicases*/genetics , DNA Helicases*/metabolism, Adenosine Triphosphatases/metabolism ; DNA Replication ; Minichromosome Maintenance Proteins/metabolism ; Translocation, Genetic
مستخلص: A six-subunit ATPase ring forms the central hub of the replication forks in all domains of life. This ring performs a helicase function to separate the two complementary DNA strands to be replicated and drives the replication machinery along the DNA. Disruption of this helicase/ATPase ring is associated with genetic instability and diseases such as cancer. The helicase/ATPase rings of eukaryotes and archaea consist of six minichromosome maintenance (MCM) proteins. Prior structural studies have shown that MCM rings bind one encircled strand of DNA in a spiral staircase, suggesting that the ring pulls this strand of DNA through its central pore in a hand-over-hand mechanism where the subunit at the bottom of the staircase dissociates from DNA and re-binds DNA one step above the staircase. With high-resolution cryo-EM, we show that the MCM ring of the archaeal organism Saccharolobus solfataricus binds an encircled DNA strand in two different modes with different numbers of subunits engaged to DNA, illustrating a plausible mechanism for the alternating steps of DNA dissociation and re-association that occur during DNA translocation.
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معلومات مُعتمدة: R35GM136313 United States GM NIGMS NIH HHS; R01 GM098771 United States GM NIGMS NIH HHS; ALSAC; R35 GM136313 United States GM NIGMS NIH HHS; R01GM098771 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: ATPase; DNA replication; helicase
المشرفين على المادة: EC 3.6.1.- (Adenosine Triphosphatases)
0 (Archaeal Proteins)
EC 3.6.4.12 (Minichromosome Maintenance Proteins)
EC 3.6.4.- (DNA Helicases)
تواريخ الأحداث: Date Created: 20221211 Date Completed: 20221229 Latest Revision: 20221229
رمز التحديث: 20221230
مُعرف محوري في PubMed: PMC9735655
DOI: 10.3390/ijms232314678
PMID: 36499022
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms232314678