دورية أكاديمية
Outcomes of Heart Transplantation Using a Temperature-controlled Hypothermic Storage System.
| العنوان: | Outcomes of Heart Transplantation Using a Temperature-controlled Hypothermic Storage System. |
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| المؤلفون: | Zhu Y; Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford University, Stanford, CA., Shudo Y, He H, Kim JY, Elde S, Williams KM, Walsh SK, Koyano TK, Guenthart B, Woo YJ |
| المصدر: | Transplantation [Transplantation] 2023 May 01; Vol. 107 (5), pp. 1151-1157. Date of Electronic Publication: 2023 Apr 22. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0132144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-6080 (Electronic) Linking ISSN: 00411337 NLM ISO Abbreviation: Transplantation Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: Baltimore, Williams & Wilkins. |
| مواضيع طبية MeSH: | Heart Transplantation*/methods , Heart Transplantation*/statistics & numerical data , Tissue and Organ Procurement*/methods , Tissue and Organ Procurement*/standards, Humans ; Ischemia/prevention & control ; Proportional Hazards Models ; Retrospective Studies ; Temperature ; Treatment Outcome ; Male ; Female ; Adult ; Middle Aged ; Survival Analysis |
| مستخلص: | Background: The SherpaPak Cardiac Transport System is a novel technology that provides stable, optimal hypothermic control during organ transport. The objectives of this study were to describe our experience using the SherpaPak system and to compare outcomes after heart transplantation after using SherpaPak versus the conventional static cold storage method (non-SherpaPak). Methods: From 2018 to June 2021, 62 SherpaPak and 186 non-SherpaPak patients underwent primary heart transplantation at Stanford University with follow-up through May 2022. The primary end point was all-cause mortality, and secondary end points were postoperative complications. Optimal variable ratio matching, cox proportional hazards regression model, and Kaplan-Meier survival analyses were performed. Results: Before matching, the SherpaPak versus non-SherpaPak patients were older and received organs with significantly longer total allograft ischemic time. After matching, SherpaPak patients required fewer units of blood product for perioperative transfusion compared with non-SherpaPak patients but otherwise had similar postoperative outcomes such as hospital length of stay, primary graft dysfunction, inotrope score, mechanical circulatory support use, cerebral vascular accident, myocardial infarction, respiratory failure, new renal failure requiring dialysis, postoperative bleeding or tamponade requiring reoperation, infection, and survival. Conclusions: In conclusion, this is one of the first retrospective comparison studies that evaluated the outcomes of heart transplantation using organs preserved and transported via the SherpaPak system. Given the excellent outcomes, despite prolonged total allograft ischemic time, it may be reasonable to adopt the SherpaPak system to accept organs from a remote location to further expand the donor pool. Competing Interests: The authors declare no funding or conflicts of interest. (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.) |
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| معلومات مُعتمدة: | R38 HL143615 United States HL NHLBI NIH HHS |
| تواريخ الأحداث: | Date Created: 20221213 Date Completed: 20230929 Latest Revision: 20240310 |
| رمز التحديث: | 20240310 |
| DOI: | 10.1097/TP.0000000000004416 |
| PMID: | 36510359 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1534-6080 |
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| DOI: | 10.1097/TP.0000000000004416 |