دورية أكاديمية
Aging reduces ABHD5 protein content in the adipose tissue of mice: The reversal effect of exercise.
| العنوان: | Aging reduces ABHD5 protein content in the adipose tissue of mice: The reversal effect of exercise. |
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| المؤلفون: | Brícola RS; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil., Cordeiro AV; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil., Crisol BM; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil., Braga RR; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil., de Melo DG; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil., Rocha MB; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil., Gaspar RC; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil., Nakandakari SCBR; Laboratory of Nutritional Genomics (LabGeN), School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil., Silva VRR; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil., Anaruma CP; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil., Katashima CK; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil., Canciglieri RDS; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil., Munõz VR; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil., Pavan ICB; Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, State University of Campinas, Limeira, São Paulo, Brazil., Pinto AP; Ribeirão Preto Medical School, School of Physical Education and Sport of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Simabuco FM; Multidisciplinary Laboratory of Food and Health, School of Applied Sciences, State University of Campinas, Limeira, São Paulo, Brazil., Silva ASRD; Ribeirão Preto Medical School, School of Physical Education and Sport of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Moura LP; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil.; CEPECE-Center of Research in Sport Sciences, School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil., Pauli JR; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil.; CEPECE-Center of Research in Sport Sciences, School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.; Laboratory of Cell Signaling-Obesity and Comorbidities Research Center, University of Campinas, Campinas, São Paulo, Brazil., Cintra DE; Laboratory of Nutritional Genomics (LabGeN), School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil.; Laboratory of Cell Signaling-Obesity and Comorbidities Research Center, University of Campinas, Campinas, São Paulo, Brazil., Ropelle ER; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil.; CEPECE-Center of Research in Sport Sciences, School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.; Laboratory of Cell Signaling-Obesity and Comorbidities Research Center, University of Campinas, Campinas, São Paulo, Brazil.; Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil. |
| المصدر: | Cell biochemistry and function [Cell Biochem Funct] 2023 Jan; Vol. 41 (1), pp. 128-137. Date of Electronic Publication: 2022 Dec 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 8305874 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-0844 (Electronic) Linking ISSN: 02636484 NLM ISO Abbreviation: Cell Biochem Funct Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford, England : Wiley-Blackwell Original Publication: Guildford, Surrey : Butterworth Scientific Ltd., c1983- |
| مواضيع طبية MeSH: | 1-Acylglycerol-3-Phosphate O-Acyltransferase*/genetics , 1-Acylglycerol-3-Phosphate O-Acyltransferase*/metabolism , Adipose Tissue*/enzymology , Aging*/metabolism , Lipolysis* , Exercise*, Adult ; Aged ; Animals ; Humans ; Mice ; Middle Aged ; Young Adult ; Hydrolases/genetics ; Hydrolases/metabolism |
| مستخلص: | Dysfunction of the adipose tissue metabolism is considered as a significant hallmark of aging. It has been proposed that α-β hydrolase domain containing 5 (ABHD5) plays a critical role in the control of lipolysis. However, the role of ABHD5 in the control of lipolysis during aging or exercise is unknown. Here we combined the experimental mouse model with transcriptomic analyzes by using murine and human databases to explore the role of ABHD5 in the adipose tissue during aging and in response to exercise. Transcriptomic data revealed a downregulation of Abhd5 messenger RNA levels in the subcutaneous white adipose tissue (scWAT) over time in individuals from 20 to 69 years old. Aged mice displayed dramatic reduction of ABHD5 protein content and lipolytic-related proteins in the scWAT. Interestingly, 4 weeks of high-intensity interval training increased ABHD5 protein level and restored the lipolytic pathway in the scWAT of aged mice. Altogether, our findings demonstrated that aging affects ABHD5 content in the adipose tissue of mice and humans. Conversely, exercise increases ABHD5 activity, recovering the lipolytic activity in aged mice. (© 2022 John Wiley & Sons Ltd.) |
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| معلومات مُعتمدة: | 2019/21709-4 Fundação de Amparo à Pesquisa do Estado de São Paulo; 2019/11820-5 and 2018/03122-3 Fundação de Amparo à Pesquisa do Estado de São Paulo; 310604/2020-6 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior |
| فهرسة مساهمة: | Keywords: ABHD5; adipose tissue; aging; physical exercise and lipolysis |
| المشرفين على المادة: | EC 2.3.1.51 (1-Acylglycerol-3-Phosphate O-Acyltransferase) EC 2.3.1.51 (ABHD5 protein, human) EC 3.- (Hydrolases) EC 2.3.1.51 (Abhd5 protein, mouse) |
| تواريخ الأحداث: | Date Created: 20221214 Date Completed: 20230203 Latest Revision: 20230203 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1002/cbf.3770 |
| PMID: | 36515301 |
| قاعدة البيانات: | MEDLINE |
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