دورية أكاديمية
Behavioral flexibility impacts on coping and emotional responses in male mice submitted to social defeat stress.
| العنوان: | Behavioral flexibility impacts on coping and emotional responses in male mice submitted to social defeat stress. |
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| المؤلفون: | Rosado AF; Laboratory of Translational Neurosciences, Department of Biochemistry, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil; Graduate Program in Neurosciences, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil., Bevilacqua LM; Laboratory of Translational Neurosciences, Department of Biochemistry, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil; Graduate Program in Neurosciences, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil., Moreira ELG; Department of Physiological Sciences, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil. Electronic address: eduardo.luiz@ufsc.br., Kaster MP; Laboratory of Translational Neurosciences, Department of Biochemistry, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil; Department of Biochemistry, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil. Electronic address: manuella.kaster@ufsc.br. |
| المصدر: | Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2023 Apr 20; Vol. 123, pp. 110696. Date of Electronic Publication: 2022 Dec 12. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 8211617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4216 (Electronic) Linking ISSN: 02785846 NLM ISO Abbreviation: Prog Neuropsychopharmacol Biol Psychiatry Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford ; New York : Pergamon Press, c1982- |
| مواضيع طبية MeSH: | Social Defeat* , Emotions*, Mice ; Animals ; Male ; Mice, Inbred C57BL ; Stress, Psychological/psychology ; Adaptation, Psychological |
| مستخلص: | Behavioral flexibility permits the appropriate behavioral adjustments in response to changing environmental demands. The present study aimed to evaluate if variability in baseline flexibility can enable differences in coping strategies, changes in neuroplasticity, and behavioral outcomes in responses to chronic social defeat stress (CSDS). Male C57BL6 mice were submitted to the Morris Water Maze (MWM) using an extended protocol for reversal learning to assess. The animals were divided into low and high behavioral flexibility groups based on their performance on the last day of acquisition versus the four days of reversal learning. The CSDS was applied for ten consecutive days, and coping strategies were evaluated during the physical interaction on the first and last day of stress. A battery of behavioral tests to assess social and emotional behavior was conducted 24 h after the CSDS protocol. The complexity of prefrontal cortex (PFC) neuronal morphology was evaluated by the Golgi-Cox method. Animals with High Flexibility exhibited changes in their CSDS coping strategies, from active to passive coping, during the CSDS protocol. Low Flexibility mice had no alterations in the coping strategies during CSDS. After social stress, High Flexibility was associated with reduced social interaction with an aggressive Swiss mouse, higher latency to immobility in the tail suspension test, and reduced latency to self-care in the sucrose splash test. High Flexibility mice also displayed higher dendritic complexity on pyramidal neurons from the prelimbic and infralimbic prefrontal cortex compared to Low Flexibility mice. These results suggest That High Flexibility is associated with increased neuroplasticity in cortical areas and better emotional responses related to behavioral despair and motivation. However, exposure to CSDS reversed the beneficial effects of High Flexibility in male mice. Thus, this study suggests that baseline variability in behavioral flexibility, even in inbred strains, might be associated with differences in coping strategies, PFC morphology, and behavioral responses to social stress. Competing Interests: Conflict of interest The authors declare no conflict of interest. (Copyright © 2022 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Behavior; Coping; Flexibility; Prefrontal cortex; Social stress |
| تواريخ الأحداث: | Date Created: 20221215 Date Completed: 20230207 Latest Revision: 20230207 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.pnpbp.2022.110696 |
| PMID: | 36521585 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1878-4216 |
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| DOI: | 10.1016/j.pnpbp.2022.110696 |