دورية أكاديمية
Insights into the spectrofluorometric determination of the neuromuscular blocker mivacurium chloride.
| العنوان: | Insights into the spectrofluorometric determination of the neuromuscular blocker mivacurium chloride. |
|---|---|
| المؤلفون: | Elmansi H; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt. Electronic address: dr_heba85@hotmail.com., Aboshabana R; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt., El-Awady MI; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Delta University for Science and Technology, International Coastal Road, Gamasa 11152, Egypt. |
| المصدر: | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2023 Mar 15; Vol. 289, pp. 122236. Date of Electronic Publication: 2022 Dec 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 9602533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3557 (Electronic) Linking ISSN: 13861425 NLM ISO Abbreviation: Spectrochim Acta A Mol Biomol Spectrosc Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: [Kidlington, Oxford, U.K. ; Tarrytown, NY] : Pergamon, c1994- |
| مواضيع طبية MeSH: | Propofol* , Neuromuscular Nondepolarizing Agents*/chemistry, Humans ; Mivacurium ; Spectrometry, Fluorescence ; Isoquinolines/chemistry ; Pharmaceutical Preparations |
| مستخلص: | Fluorescence spectroscopy is gaining interest in the analysis and quantitative determination of different drugs. This study was carried out to investigate the fluorometric properties of the short-acting muscle relaxant mivacurium in its pure form, injection, and human plasma. It is nondepolarizing skeletal muscle relaxant for intravenous (IV) administration. Mivacurium shows a strong native fluorescence in methanol at 317 nm after excitation at 230 nm (Method I). The critical parameters that may influence the fluorescence of this drug were carefully studied. A linear response between concentration and fluorescence was constructed over the concentration range: 20.0 to 400.0 ng/mL with determination coefficient (r 2 ) equal to 0.9998. Additionally, the correlation coefficient of the linear relationship (r) was found to be 0.9999 with a slope = 2.196 and intercept = -16.61. Limits of quantitation and detection were calculated mathematically to be 17.45 and 5.75 ng/mL respectively. Further estimation of mivacurium in spiked human plasma was performed by construction of specific calibration curve and the obtained correlation coefficient was 0.9948. Moreover, the ability to determine mivacurium in the presence of commonly co-administered drugs were investigated including propofol and thiopental. Method II includes the determination of MVC in the presence of propofol utilizing the first derivative synchronous fluorescence spectroscopy. The results of method II indicated acceptable percentage recoveries from 98.88 to 100.75 %. Statistical evaluation of the results revealed satisfactory accuracy and precision. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2022 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Co-administered; Fluorescence; Mivacurium; Plasma |
| المشرفين على المادة: | 77D66S9Q93 (Mivacurium) 0 (Isoquinolines) YI7VU623SF (Propofol) 0 (Neuromuscular Nondepolarizing Agents) 0 (Pharmaceutical Preparations) |
| تواريخ الأحداث: | Date Created: 20221217 Date Completed: 20230117 Latest Revision: 20230117 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.saa.2022.122236 |
| PMID: | 36527966 |
| قاعدة البيانات: | MEDLINE |
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