دورية أكاديمية
Variations in the TAS2R38 gene among college students in Hubei.
| العنوان: | Variations in the TAS2R38 gene among college students in Hubei. |
|---|---|
| المؤلفون: | Wang X; School of Basic Medicine, Hubei University of Arts and Science, Xiangyang, 441053, China., Wang L; Xiangyang Stomatological Hospital, Affiliated Stomatological Hospital of Hubei University of Arts and Science, 441003, Xiangyang, China., Xia M; School of Basic Medicine, Hubei University of Arts and Science, Xiangyang, 441053, China., Teng F; School of Basic Medicine, Hubei University of Arts and Science, Xiangyang, 441053, China., Chen X; School of Basic Medicine, Hubei University of Arts and Science, Xiangyang, 441053, China., Huang R; School of Basic Medicine, Hubei University of Arts and Science, Xiangyang, 441053, China., Zhou J; School of Basic Medicine, Hubei University of Arts and Science, Xiangyang, 441053, China., Xiao J; School of Basic Medicine, Hubei University of Arts and Science, Xiangyang, 441053, China., Zhai L; School of Basic Medicine, Hubei University of Arts and Science, Xiangyang, 441053, China. lihongzhai@hbuas.edu.cn. |
| المصدر: | Hereditas [Hereditas] 2022 Dec 19; Vol. 159 (1), pp. 46. Date of Electronic Publication: 2022 Dec 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 0374654 Publication Model: Electronic Cited Medium: Internet ISSN: 1601-5223 (Electronic) Linking ISSN: 00180661 NLM ISO Abbreviation: Hereditas Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oct. 2015- : London : BioMed Central Ltd. Original Publication: Lund : Mendelska sällskapet. |
| مواضيع طبية MeSH: | Phenylthiourea* , Receptors, G-Protein-Coupled*/genetics , Taste*/genetics, Female ; Humans ; Male ; Asian People/genetics ; Students |
| مستخلص: | Background: The bitter taste receptor gene TAS2R38 is a member of the human TAS2R gene family. Polymorphisms in TAS2R38 affect the ability to taste the bitterness of phenylthiourea (PTC) compounds, thus affecting an individual's food preference and health status. Methods: We investigated polymorphisms in the TAS2R38 gene and the sensitivity to PTC bitterness among healthy Chinese college students in Hubei province. The association of TAS2R38 polymorphisms and PTC sensitivity with body mass index (BMI), food preference, and health status was also analyzed. A total of 320 healthy college students were enrolled (male: 133, female: 187; aged 18-23 years). The threshold value method was used to measure the perception of PTC bitterness, and a questionnaire was used to analyze dietary preferences and health status. Polymerase chain reaction (PCR) was used to analyze polymorphisms at three common TAS2R38 loci (rs713598, rs1726866, and rs10246939). Results: In our study population, 65.00% of individuals had medium sensitivity to the bitterness of PTC; in contrast, 20.94% were highly sensitive to PTC bitterness, and 14.06% were not sensitive. For the TAS2R38 gene, the PAV/PAV and PAV/AAI diplotypes were the most common (42.19% and 40.63%, respectively), followed by the homozygous AVI/AVI (8.75%) and PAV/AVI (5.00%) diplotypes. Conclusion: There was a significant correlation between the sensitivity to PTC bitterness and sex, but there was no correlation between the common diplotypes of TAS2R38 and gender. Polymorphisms in the TAS2R38 gene were associated with the preference for tea, but not with one's native place, BMI, health status, or other dietary preferences. There was no significant correlation between the perception of PTC bitterness and one's native place, BMI, dietary preference, or health status. We hope to find out the relationship between PTC sensitivity and TAS2R38 gene polymorphisms and dietary preference and health status of Chinese population through this study, providing relevant guidance and suggestions for dietary guidance and prevention of some chronic diseases in Chinese population. (© 2022. The Author(s).) |
| References: | Science. 2003 Feb 21;299(5610):1221-5. (PMID: 12595690) PLoS One. 2013;8(3):e59810. (PMID: 23555788) Gene. 2017 Sep 5;627:363-368. (PMID: 28652185) Am J Hum Genet. 1998 Nov;63(5):1271-6. (PMID: 9792854) Curr Biol. 2005 Feb 22;15(4):322-7. (PMID: 15723792) J Dent Res. 2004 Jun;83(6):448-53. (PMID: 15153450) Food Qual Prefer. 2013 Dec;30(2):202-216. (PMID: 23878414) Clin Genet. 2005 Apr;67(4):275-80. (PMID: 15733260) Genes Nutr. 2019 May 03;14:13. (PMID: 31073343) Appetite. 2017 Sep 1;116:57-64. (PMID: 28455260) Annu Rev Nutr. 2007;27:389-414. (PMID: 17444812) Int Arch Allergy Immunol. 2019;180(1):72-78. (PMID: 31137020) PLoS One. 2011;6(11):e27745. (PMID: 22132133) PLoS One. 2016 Oct 6;11(10):e0164157. (PMID: 27711175) Ann Hum Biol. 2001 Mar-Apr;28(2):111-42. (PMID: 11293722) Appetite. 2017 Jun 1;113:178-186. (PMID: 28232057) Sci Rep. 2016 May 03;6:25506. (PMID: 27138342) J Pediatr Gastroenterol Nutr. 2012 May;54(5):624-9. (PMID: 22197939) J Nutrigenet Nutrigenomics. 2009;2(4-5):251-6. (PMID: 20484932) Springerplus. 2015 Sep 17;4:505. (PMID: 26405625) Annu Rev Genomics Hum Genet. 2005;6:217-35. (PMID: 16124860) Hum Biol. 1964 May;36:134-45. (PMID: 14167588) Obesity (Silver Spring). 2009 May;17(5):937-8; author reply 939. (PMID: 19396080) Physiol Behav. 2016 Mar 15;156:117-27. (PMID: 26785164) Am J Clin Nutr. 2006 Jul;84(1):245-51. (PMID: 16825702) Nutrients. 2019 Aug 21;11(9):. (PMID: 31438650) Nutr Rev. 2001 Jun;59(6):163-9. (PMID: 11444592) J Clin Invest. 2012 Nov;122(11):4145-59. (PMID: 23041624) Nat Genet. 2002 Nov;32(3):397-401. (PMID: 12379855) Chem Senses. 2008 Mar;33(3):255-65. (PMID: 18209019) J Nutrigenet Nutrigenomics. 2013;6(1):43-58. (PMID: 23548722) Am J Clin Nutr. 2013 Oct;98(4):1136-43. (PMID: 24025627) Obesity (Silver Spring). 2008 Oct;16(10):2289-95. (PMID: 18719631) Am J Hum Genet. 2004 Apr;74(4):637-46. (PMID: 14997422) Neurosci Biobehav Rev. 2001 Jan;25(1):53-74. (PMID: 11166078) J Am Diet Assoc. 2007 Aug;107(8):1340-8. (PMID: 17659901) Sci Rep. 2016 Jun 01;6:26904. (PMID: 27245112) PLoS One. 2013 Dec 02;8(12):e80512. (PMID: 24312479) Arch Gerontol Geriatr. 2012 Mar-Apr;54(2):e13-8. (PMID: 21763010) Physiol Behav. 1994 Dec;56(6):1165-71. (PMID: 7878086) Curr Opin Allergy Clin Immunol. 2015 Feb;15(1):14-20. (PMID: 25304231) J Nutr Sci Vitaminol (Tokyo). 2013;59(1):16-21. (PMID: 23535535) Int J Food Sci Nutr. 2018 Mar;69(2):245-252. (PMID: 28738701) Physiol Behav. 2000 Apr 1-15;69(1-2):161-73. (PMID: 10854927) Int J Mol Sci. 2020 Jul 21;21(14):. (PMID: 32708215) Am J Clin Nutr. 1995 Sep;62(3):506-11. (PMID: 7661111) Forum Nutr. 2007;60:176-182. (PMID: 17684414) Mol Biol Evol. 2012 Apr;29(4):1141-53. (PMID: 22130969) Scand J Clin Lab Invest. 2011 Jul;71(4):274-9. (PMID: 21338274) Chemosens Percept. 2010 Dec 1;3(3-4):137-148. (PMID: 21157576) Physiol Behav. 2006 Feb 28;87(2):304-13. (PMID: 16368118) Chem Senses. 2013 Jul;38(6):475-84. (PMID: 23632915) |
| معلومات مُعتمدة: | 2021kptd01 the Science and Technology Innovation Team Project of Hubei University of Arts and Science; 2019 the Xiangyang Youth Science and Technology Talent Development Plan; S202110519032，X202210519196 and X202210519216 the Undergraduate Training Programs for Innovation and Entrepreneurship; 2022YL01A the Bureau of Xiangyang City Science and Technology projects |
| فهرسة مساهمة: | Keywords: Bitter taste receptor; Phenylthiourea; Polymorphism; TAS2R38 |
| المشرفين على المادة: | 6F82C6Q54C (Phenylthiourea) 0 (Receptors, G-Protein-Coupled) 0 (taste receptors, type 2) |
| تواريخ الأحداث: | Date Created: 20221218 Date Completed: 20230106 Latest Revision: 20230106 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC9762079 |
| DOI: | 10.1186/s41065-022-00260-x |
| PMID: | 36529808 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1601-5223 |
|---|---|
| DOI: | 10.1186/s41065-022-00260-x |