دورية أكاديمية
أعرض في EDS

Frailty and functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI): baseline results from the SYNERGIC Trial.

التفاصيل البيبلوغرافية
العنوان: Frailty and functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI): baseline results from the SYNERGIC Trial.
المؤلفون: Bray NW; Cumming School of Medicine, Department of Physiology & Pharmacology, University of Calgary, Calgary, AB, T2N 1N4, Canada. nicholas.bray@ucalgary.ca.; Gait and Brain Lab, Parkwood Institute, Lawson Health Research Institute, 550 Wellington Road, Room A3-116, London, ON, N6C-0A7, Canada. nicholas.bray@ucalgary.ca., Pieruccini-Faria F; Gait and Brain Lab, Parkwood Institute, Lawson Health Research Institute, 550 Wellington Road, Room A3-116, London, ON, N6C-0A7, Canada.; Department of Medicine, Division of Geriatric Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A-5C1, Canada., Witt ST; BrainsCAN, Western University, London, ON, N6A-3K7, Canada., Rockwood K; Department of Medicine, Dalhousie University, Halifax, NS, Canada., Bartha R; Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, N6A-5C1, Canada.; Robarts Research Institute, Western University, London, ON, N6A-5B7, Canada., Doherty TJ; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, N6A-5C1, Canada.; Department of Physical Medicine and Rehabilitation, Schulich School of Medicine and Dentistry, Western University, London, ON, N6A-5C1, Canada., Nagamatsu LS; Faculty of Health Sciences, School of Kinesiology, Western University, London, ON, N6G-2V4, Canada., Almeida QJ; Faculty of Science, Department of Kinesiology and Physical Education, Wilfrid Laurier University, Waterloo, ON, N2L-3C5, Canada., Liu-Ambrose T; Department of Physical Therapy, University of British Columbia, BC, V6T-1Z3, Vancouver, Canada.; Centre for Aging SMART at Vancouver Coastal Health, Vancouver, BC, Canada., Middleton LE; Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, N2L-3G1, Canada., Bherer L; Department of Medicine, University of Montréal, Montréal, QC, H3T-1J4, Canada.; Research Centre, Montreal Heart Institute, Montréal, QC, H1T-1C8, Canada., Montero-Odasso M; Gait and Brain Lab, Parkwood Institute, Lawson Health Research Institute, 550 Wellington Road, Room A3-116, London, ON, N6C-0A7, Canada. mmontero@uwo.ca.; Department of Medicine, Division of Geriatric Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A-5C1, Canada. mmontero@uwo.ca.; Department of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A-5C1, Canada. mmontero@uwo.ca.
المصدر: GeroScience [Geroscience] 2023 Apr; Vol. 45 (2), pp. 1033-1048. Date of Electronic Publication: 2022 Dec 21.
نوع المنشور: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cham : Springer International Publishing, [2017]-
مواضيع طبية MeSH: Cognitive Dysfunction*/diagnostic imaging , Dementia*/complications , Frailty*/complications, Aged ; Female ; Humans ; Male ; Brain/diagnostic imaging ; Cross-Sectional Studies
مستخلص: Functional brain connectivity (FBC), or areas that are anatomically separate but temporally synchronized in their activation, represent a sensitive biomarker for monitoring dementia progression. It is unclear whether frailty is associated with FBC in those at higher risk of progression to dementia (e.g., mild cognitive impairment -MCI-) and if sex plays a role. We used baseline data from the SYNERGIC trial, including participants with MCI that received brain MRI. In this cross-sectional analyses (n = 100), we measured frailty using a deficit accumulation frailty index. Using the CONN toolbox, we assessed FBC of networks and regions of interest across the entire connectome. We used Pearson's correlation to investigate the relationship between FBC and frailty index in the full sample and by sex. We also divided the full sample and each sex into tertiles based upon their frailty index score and then assessed between-tertile differences in FBC. The full sample (cluster: size = 291 p-FDR < 0.05) and males (cluster: size = 993 and 451 p-FDR < 0.01) demonstrated that increasing (stronger) connectivity between the right hippocampus and clusters in the temporal gyrus was positively correlated with increasing (worse) frailty. Males also demonstrated between-tertile differences in right hippocampus connectivity to clusters in the lateral occipital cortex (cluster: size = 289 p-FDR < 0.05). Regardless of frailty status, females demonstrated stronger within-network connectivity of the Default-Mode (p = 0.024). Our results suggest that increasing (worse) frailty was associated with increasing (stronger) connectivity between regions not typically linked, which may reflect a compensation tactic by the plastic brain. Furthermore, the relationship between the two variables appears to differ by sex. Our results may help elucidate why specific individuals progress to a dementia syndrome. NCT02808676. https://www.clinicaltrials.gov/ct2/show/NCT02808676.
(© 2022. The Author(s), under exclusive licence to American Aging Association.)
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معلومات مُعتمدة: MOP 211220 Canada CIHR; PJT 153100 Canada CIHR
فهرسة مساهمة: Keywords: Cross-sectional; Frailty; Functional brain connectivity; Mild cognitive impairment; Older adults; fMRI
سلسلة جزيئية: ClinicalTrials.gov NCT02808676
تواريخ الأحداث: Date Created: 20221220 Date Completed: 20230204 Latest Revision: 20240911
رمز التحديث: 20240911
مُعرف محوري في PubMed: PMC9767804
DOI: 10.1007/s11357-022-00702-4
PMID: 36539590
قاعدة البيانات: MEDLINE
الوصف
تدمد:2509-2723
DOI:10.1007/s11357-022-00702-4