دورية أكاديمية
Cortical reintegration after facial allotransplantation.
| العنوان: | Cortical reintegration after facial allotransplantation. |
|---|---|
| المؤلفون: | Washington KM; Department of Plastic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Department of Surgery, University of Colorado School of Medicine, CU Anschutz Medical Campus, Aurora, Colorado., Solari MG; Department of Plastic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Zanoun RR; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Kwegyir-Afful EE; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Su AA; Department of Plastic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Department of Surgery, University of Colorado School of Medicine, CU Anschutz Medical Campus, Aurora, Colorado., Carvell GE; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Lee WPA; Department of Plastic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas., Simons DJ; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. |
| المصدر: | Journal of neurophysiology [J Neurophysiol] 2023 Feb 01; Vol. 129 (2), pp. 421-430. Date of Electronic Publication: 2022 Dec 21. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 0375404 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1598 (Electronic) Linking ISSN: 00223077 NLM ISO Abbreviation: J Neurophysiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Bethesda Md : American Physiological Society Original Publication: Washington [etc.] |
| مواضيع طبية MeSH: | Facial Transplantation*, Rats ; Animals ; Neurons/physiology ; Thalamus/physiology ; Somatosensory Cortex/physiology ; Vibrissae/physiology ; Physical Stimulation |
| مستخلص: | Neural plasticity of the brain or its ability to reorganize following injury has likely coincided with the successful clinical correction of severe deformity by facial transplantation since 2005. In this study, we present the cortical reintegration outcomes following syngeneic hemifacial vascularized composite allograft (VCA) in a small animal model. Specifically, changes in the topographic organization and unit response properties of the rodent whisker-barrel somatosensory system were assessed following hemifacial VCA. Clear differences emerged in the barrel-cortex system when comparing naïve and hemiface transplanted animals. Neurons in the somatosensory cortex of transplanted rats had decreased sensitivity albeit increased directional sensitivity compared with naïve rats and evoked responses in transplanted animals were more temporally dispersed. In addition, receptive fields were often topographically mismatched with the indication that the mismatched topography reorganized within adjacent barrel (same row-arc bias following hemifacial transplant). These results suggest subcortical changes in the thalamus and/or brainstem play a role in hemifacial transplantation cortical plasticity and demonstrate the discrete and robust data that can be derived from this clinically relevant small animal VCA model for use in optimizing postsurgical outcomes. NEW & NOTEWORTHY Robust rodent hemifacial transplant model was used to record functional changes in somatosensory cortex after transplantation. Neurons in the somatosensory cortex of face transplant recipients had decreased sensitivity to stimulation of whiskers with increased directional sensitivity vs. naive rats. Transplant recipient cortical unit response was more dispersed in temporary vs. naive rats. Despite histological similarities to naive cortices, transplant recipient cortices had a mix of topographically appropriate and inappropriate whiskered at barrel cortex relationships. |
| فهرسة مساهمة: | Keywords: cortex; face transplant; plasticity; somatosensory; vascularized composite allotransplantation |
| تواريخ الأحداث: | Date Created: 20221221 Date Completed: 20230216 Latest Revision: 20230224 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1152/jn.00349.2022 |
| PMID: | 36542405 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1522-1598 |
|---|---|
| DOI: | 10.1152/jn.00349.2022 |