دورية أكاديمية
أعرض في EDS

Pitfalls and management of corrective spinal surgery in trisomy 9 mosaicism: a report of three cases.

التفاصيل البيبلوغرافية
العنوان: Pitfalls and management of corrective spinal surgery in trisomy 9 mosaicism: a report of three cases.
المؤلفون: Legister CS; Research Department, Gillette Children's, Saint Paul, MN, USA., Harding DC; Department of Orthopedics- Spine, 200 University Avenue East, Gillette Children's, MN, 55101, Saint Paul, USA., Morgan SJ; Research Department, Gillette Children's, Saint Paul, MN, USA.; Department of Rehabilitation Medicine, University of Minnesota, MN, Minneapolis, USA.; Department of Rehabilitation Medicine, University of Washington, Seattle, WA, USA., Guillaume TJ; Department of Orthopedics- Spine, 200 University Avenue East, Gillette Children's, MN, 55101, Saint Paul, USA. tennerguillaume@gillettechildrens.com.
المصدر: Spine deformity [Spine Deform] 2023 May; Vol. 11 (3), pp. 759-764. Date of Electronic Publication: 2022 Dec 22.
نوع المنشور: Case Reports; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Nature Country of Publication: England NLM ID: 101603979 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-1358 (Electronic) Linking ISSN: 2212134X NLM ISO Abbreviation: Spine Deform Subsets: MEDLINE
أسماء مطبوعة: Publication: 2020- : London : Springer Nature
Original Publication: New York, N.Y. : Elsevier
مواضيع طبية MeSH: Spine*/diagnostic imaging , Spine*/surgery , Kyphosis*/etiology, Humans ; Uniparental Disomy ; Reoperation/adverse effects
مستخلص: Purpose: The aim of this case series is to present the outcomes of surgical correction of hyperkyphosis, and subsequent management of complications for three patients with a rare chromosomopathy, Trisomy 9 Mosaicism (T9M).
Methods: Case series with 2 year outcomes following index surgery.
Results: Case 1 presented at 9 years of age with 103° of kyphosis (T3-T10), which progressed to 118° despite bracing. Case 2 presented at 7 years of age with 113° of kyphosis (T3-T11). Case 3 presented at 4 years of age with 103° of kyphosis (T1-T11). Cases 1 and 2 underwent T2-L2 posterior instrumented spinal fusion (PISF). Upon follow up, radiographs for Cases 1 and 2 revealed severe, symptomatic proximal junctional kyphosis (PJK) of 71° and 50°, respectively, requiring surgical revision proximally to the C4 level. Case 3 underwent placement of magnetically controlled growing rods given young age and growth potential. Surgical levels for Case 3 were extended from C4-pelvis in an attempt to prevent development of symptomatic PJK. Most recent radiographs for Case 3 taken 21 months postoperatively demonstrate a stable 50° of kyphosis. PJK above C4 was noted but is stable and asymptomatic.
Conclusion: T9M often presents with progressive hyperkyphosis. Despite instrumentation above the upper end vertebra (UEV), PJK may be a common complication in this small patient population. This novel report on spine deformity correction in the T9M population may provide preliminary guidance for the treatment of hyperkyphosis in patients with T9M and help surgeons avoid common pitfalls.
Level of Evidence: IV.
(© 2022. The Author(s), under exclusive licence to Scoliosis Research Society.)
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فهرسة مساهمة: Keywords: Hyperkyphosis; Posterior instrumented spinal fusion; Proximal junctional kyphosis; Trisomy 9 Mosaicism
SCR Disease Name: Chromosome 9, trisomy mosaic
تواريخ الأحداث: Date Created: 20221222 Date Completed: 20230501 Latest Revision: 20230502
رمز التحديث: 20230503
DOI: 10.1007/s43390-022-00624-3
PMID: 36547810
قاعدة البيانات: MEDLINE
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