دورية أكاديمية
Region-specific involvement of ventral striatal dopamine D2 receptor-expressing medium spiny neurons in nociception.
| العنوان: | Region-specific involvement of ventral striatal dopamine D2 receptor-expressing medium spiny neurons in nociception. |
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| المؤلفون: | Natsubori A; Sleep Disorders Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan. Electronic address: natsubori-ak@igakuken.or.jp., Miyazawa M; Sleep Disorders Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan; Faculty of Science Division Ⅱ, Tokyo University of Science, 1-3, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan., Kojima T; Sleep Disorders Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan., Honda M; Sleep Disorders Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan. |
| المصدر: | Neuroscience research [Neurosci Res] 2023 Jun; Vol. 191, pp. 48-56. Date of Electronic Publication: 2022 Dec 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Ireland NLM ID: 8500749 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8111 (Electronic) Linking ISSN: 01680102 NLM ISO Abbreviation: Neurosci Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Original Publication: [Shannon : Elsevier Scientific Publishers Ireland, c1984- |
| مواضيع طبية MeSH: | Nociception* , Ventral Striatum*, Mice ; Animals ; Medium Spiny Neurons ; Receptors, Dopamine D2/metabolism ; Corpus Striatum/metabolism ; Neurons/physiology ; Receptors, Dopamine D1/metabolism ; Mice, Transgenic ; Mice, Inbred C57BL |
| مستخلص: | The ventrolateral striatum (VLS), a subregion of the ventral striatum (VS), possesses distinct neuronal Ca 2+ activities and functions in reward-oriented behavior, compared with the ventromedial striatum (VMS) based on the anatomical feature. We hypothesized that the VLS exhibits unique neuronal activity and function in nociceptive processing, a part of aversive processing. Using fiber photometry to monitor the neuronal Ca 2+ activities, we demonstrated that acute noxious mechanical stimuli like tail-pinch increased the Ca 2+ activity of dopamine D2 receptor-expressing medium spiny neurons (D2-MSNs) in the VLS in correlation with the stimulus intensities in mice, whereas mechanical stimuli increased the VMS D2-MSN activity independent of the stimulus intensities. Likewise, thermal stimuli decreased the VLS and VMS D2-MSN Ca 2+ activities during nociceptive behaviors in the hot plate test. Furthermore, the VLS D2-MSNs increased their Ca 2+ activity accompanied by formalin-induced nociceptive behaviors in mice, whereas the VMS D2-MSNs decreased it. The optogenetic inhibition of VLS D2-MSN activity increased the formalin-induced pain-related behavior in mice, thus suggesting the inhibitory effect of VLS D2-MSN activity on chemical nociceptive behavior, in contrast to previous reports that the VMS D2-MSNs could not involve the behavior. Therefore, the VLS D2-MSNs exhibited region-specific roles in nociception. Competing Interests: Conflict of interest The authors declare no competing financial interests. (Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Fiber photometry; Medium spiny neuron; Nociception; Optogenetics; Pain; Ventral striatum |
| المشرفين على المادة: | 0 (Receptors, Dopamine D2) 0 (Receptors, Dopamine D1) |
| تواريخ الأحداث: | Date Created: 20221222 Date Completed: 20230508 Latest Revision: 20230508 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/j.neures.2022.12.008 |
| PMID: | 36549387 |
| قاعدة البيانات: | MEDLINE |
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