دورية أكاديمية
أعرض في EDS

Effects of liraglutide on depressive behavior in a mouse depression model and cognition in the probe trial of Morris water maze test.

التفاصيل البيبلوغرافية
العنوان: Effects of liraglutide on depressive behavior in a mouse depression model and cognition in the probe trial of Morris water maze test.
المؤلفون: Seo MK; Paik Institute for Clinical Research, Inje University, Busan, Republic of Korea., Jeong S; Paik Institute for Clinical Research, Inje University, Busan, Republic of Korea; Department of Healthcare Information Technology, Inje University, Gimhae, Republic of Korea; Institute for Digital Antiaging and Healthcare, Inje University, Gimhae, Republic of Korea., Seog DH; Department of Biochemistry, College of Medicine, Inje University, Busan, Republic of Korea; Dementia and Neurodegenerative Disease Research Center, College of Medicine, Inje University, Busan, Republic of Korea; Department of Convergence Biomedical Science, College of Medicine, Inje University, Busan, Republic of Korea., Lee JA; Department of Psychiatry, College of Medicine, Haeundae Paik Hospital, Inje University, Busan, Republic of Korea., Lee JH; Department of Psychiatry, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada., Lee Y; Brain and Cognition Discovery Foundation, Toronto, ON, Canada., McIntyre RS; Departments of Psychiatry and Pharmacology, University of Toronto, Toronto, ON, Canada; Mood Disorders Psychopharmacology Unit, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada., Park SW; Paik Institute for Clinical Research, Inje University, Busan, Republic of Korea; Department of Convergence Biomedical Science, College of Medicine, Inje University, Busan, Republic of Korea. Electronic address: swpark@inje.ac.kr., Lee JG; Paik Institute for Clinical Research, Inje University, Busan, Republic of Korea; Department of Psychiatry, College of Medicine, Haeundae Paik Hospital, Inje University, Busan, Republic of Korea. Electronic address: iybihwc@inje.ac.kr.
المصدر: Journal of affective disorders [J Affect Disord] 2023 Mar 01; Vol. 324, pp. 8-15. Date of Electronic Publication: 2022 Dec 23.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
مواضيع طبية MeSH: Liraglutide*/pharmacology , Liraglutide*/therapeutic use , Morris Water Maze Test*, Mice ; Animals ; Depression/drug therapy ; Maze Learning ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Cognition ; Glucagon-Like Peptide 1 ; Disease Models, Animal ; Behavior, Animal ; Stress, Psychological
مستخلص: Background: We investigated the effects of liraglutide, a glucagon-like peptide-1 (GLP-1) agonist, on a depression-like phenotype in mice exposed to chronic unpredictable stress (CUS). Learning and memory were also assessed using the Morris water maze (MWM) test.
Methods: Liraglutide (0.3 mg/kg/day for 21 days) was administered to mice with or without exposure to CUS. After 21 days of CUS, the forced swim test (FST) was performed to assess its antidepressant effect. To evaluate cognitive function, liraglutide was administered to mice under stress-free conditions for 21 days, and then the MWM test was performed on 6 consecutive days.
Results: Chronic liraglutide treatment reduced FST immobility in mice with and without CUS. In the probe trial of the Morris water maze test, the search error rate was reduced and the time spent and path length in the target quadrant and the number of platform crossings were increased.
Limitation: Additional animal model experiments and molecular level studies are needed to support the results obtained in this study.
Conclusions: Liraglutide appears to exert antidepressant effects and could improve cognitive function. Based on these results, GLP-1 agonists could have potential as novel antidepressants.
Competing Interests: Conflict of interest Dr. Roger McIntyre has received research grant support from CIHR/GACD/National Natural Science Foundation of China (NSFC); speaker/consultation fees from Lundbeck, Janssen, Alkermes, Mitsubishi Tanabe, Purdue, Pfizer, Otsuka, Takeda, Neurocrine, Sunovion, Bausch Health, Novo Nordisk, Kris, Sanofi, Eisai, Intra-Cellular, NewBridge Pharmaceuticals, Abbvie, Atai Life Sciences. Dr. Roger McIntyre is a CEO of Braxia Scientific Corp.
(Copyright © 2022. Published by Elsevier B.V.)
فهرسة مساهمة: Keywords: Antidepressant effect; Chronic unpredictable stress; Depression; GLP-1 agonist; Liraglutide; Morris water maze
المشرفين على المادة: 839I73S42A (Liraglutide)
0 (Antidepressive Agents)
89750-14-1 (Glucagon-Like Peptide 1)
تواريخ الأحداث: Date Created: 20221225 Date Completed: 20230123 Latest Revision: 20230317
رمز التحديث: 20240628
DOI: 10.1016/j.jad.2022.12.089
PMID: 36566932
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-2517
DOI:10.1016/j.jad.2022.12.089