دورية أكاديمية
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Protective effect of sex steroid hormones on morphological and cellular outcomes after neonatal hypoxia-ischemia: A meta-analysis of preclinical studies.

التفاصيل البيبلوغرافية
العنوان: Protective effect of sex steroid hormones on morphological and cellular outcomes after neonatal hypoxia-ischemia: A meta-analysis of preclinical studies.
المؤلفون: Durán-Carabali LE; Graduate Program in Biological Sciences: Physiology, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. Electronic address: luzeled67@gmail.com., Da Silva JL; Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Colucci ACM; Graduate Program in Biological Sciences: Physiology, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Netto CA; Graduate Program in Biological Sciences: Physiology, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Department of Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., De Fraga LS; Graduate Program in Biological Sciences: Physiology, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. Electronic address: lucianof@ufrgs.br.
المصدر: Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2023 Feb; Vol. 145, pp. 105018. Date of Electronic Publication: 2022 Dec 23.
نوع المنشور: Journal Article; Meta-Analysis; Systematic Review; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Pergamon Press Country of Publication: United States NLM ID: 7806090 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7528 (Electronic) Linking ISSN: 01497634 NLM ISO Abbreviation: Neurosci Biobehav Rev Subsets: MEDLINE
أسماء مطبوعة: Publication: New York Ny : Pergamon Press
Original Publication: Fayetteville, N. Y., ANKHO International Inc.
مواضيع طبية MeSH: Gonadal Steroid Hormones* , Hypoxia-Ischemia, Brain*/drug therapy , Hypoxia-Ischemia, Brain*/metabolism, Animals ; Animals, Newborn ; Brain ; Estradiol ; Ischemia ; Progesterone/pharmacology ; Progesterone/therapeutic use
مستخلص: Sex steroid hormones play an important role in fetal development, brain functioning and neuronal protection. Growing evidence highlights the positive effects of these hormones against brain damage induced by neonatal hypoxia-ischemia (HI). This systematic review with meta-analysis aims to verify the efficacy of sex steroid hormones in preventing HI-induced brain damage in rodent models. The protocol was registered at PROSPERO and a total of 22 articles were included. Moderate to large effects were observed in HI animals treated with sex steroid hormones in reducing cerebral infarction size and cell death, increasing neuronal survival, and mitigating neuroinflammatory responses and astrocyte reactivity. A small effect was evidenced for cognitive function, but no significant effect for motor function; moreover, a high degree of heterogeneity was observed. In summary, data suggest that sex steroid hormones, such as progesterone and 17β estradiol, improve morphological and cellular outcomes following neonatal HI. Further research is paramount to examine neurological function during HI recovery and standardization of methodological aspects is imperative to reduce the risk of spurious findings.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: Brain development; Cell death; Hypoxia-ischemia; Neuroinflammation; Neuroprotection; Steroid hormones
المشرفين على المادة: 4TI98Z838E (Estradiol)
0 (Gonadal Steroid Hormones)
4G7DS2Q64Y (Progesterone)
تواريخ الأحداث: Date Created: 20221226 Date Completed: 20230209 Latest Revision: 20230223
رمز التحديث: 20230224
DOI: 10.1016/j.neubiorev.2022.105018
PMID: 36572200
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-7528
DOI:10.1016/j.neubiorev.2022.105018