دورية أكاديمية
Task parameters influence operant response variability in mice.
| العنوان: | Task parameters influence operant response variability in mice. |
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| المؤلفون: | Follman EG; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA., Chevée M; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA., Kim CJ; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA., Johnson AR; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA., Tat J; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA., Leonard MZ; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA., Calipari ES; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA. erin.calipari@vanderbilt.edu.; Vanderbilt Brain Institute, Vanderbilt University, 865F Light Hall, 2215 Garland Avenue, Nashville, TN, 37232, USA. erin.calipari@vanderbilt.edu.; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN, USA. erin.calipari@vanderbilt.edu.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA. erin.calipari@vanderbilt.edu.; Department of Psychiatry and Behavioral Sciences, Vanderbilt University, Nashville, TN, USA. erin.calipari@vanderbilt.edu. |
| المصدر: | Psychopharmacology [Psychopharmacology (Berl)] 2023 Jan; Vol. 240 (1), pp. 213-225. Date of Electronic Publication: 2022 Dec 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin, New York, Springer-Verlag. |
| مواضيع طبية MeSH: | Conditioning, Operant*/physiology , Sucrose*, Mice ; Animals ; Reinforcement Schedule ; Time Factors |
| مستخلص: | Rationale: During operant conditioning, animals associate actions with outcomes. However, patterns and rates of operant responding change over learning, which makes it difficult to distinguish changes in learning from general changes in performance or movement. Thus, understanding how task parameters influence movement execution is essential. Objectives: To understand how specific operant task parameters influenced the repetition of future operant responses, we investigated the ability of operant conditioning schedules and contingencies to promote reproducible bouts of five lever presses in mice. Methods: Mice were trained on one of the four operant tasks to test three distinct hypotheses: (1) whether a cue presented concurrently with sucrose delivery influenced the pattern of lever pressing; (2) whether requiring animals to collect earned sucrose promoted the organization of responses into bouts; and (3) whether only reinforcing bouts where interresponse time (IRT) variances were below a target promoted reproducible patterns of operant behavior. Results: (1) Signaling reinforcer delivery with a cue increased learning rates but resulted in mice pressing the lever in fast succession until the cue turned on, rather than executing discrete bouts. (2) Requiring mice to collect the reinforcer between bouts had little effect on behavior. (3) A training strategy that directly reinforced bouts with low variance IRTs was not more effective than a traditional fixed ratio schedule at promoting reproducible action execution. Conclusions: Together, our findings provide insights into the parameters of behavioral training that promote reproducible actions and that should be carefully selected when designing operant conditioning experiments. (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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| معلومات مُعتمدة: | DP1 DA048931 United States DA NIDA NIH HHS; T32 MH065215 United States MH NIMH NIH HHS; R00 DA042111 United States DA NIDA NIH HHS; P50 HD103537 United States HD NICHD NIH HHS; R01 DA052317 United States DA NIDA NIH HHS; K99 DA042111 United States DA NIDA NIH HHS |
| فهرسة مساهمة: | Keywords: FR5; Fixed ratio; Interresponse times; Learning; Movement kinematics; Reinforcement schedule; Reinforcer; Reward |
| المشرفين على المادة: | 57-50-1 (Sucrose) |
| تواريخ الأحداث: | Date Created: 20221226 Date Completed: 20230109 Latest Revision: 20230703 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC9894580 |
| DOI: | 10.1007/s00213-022-06298-z |
| PMID: | 36572717 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1432-2072 |
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| DOI: | 10.1007/s00213-022-06298-z |