دورية أكاديمية
METTL14 Regulates Intestine Cellular Senescence through m 6 A Modification of Lamin B Receptor.
العنوان: | METTL14 Regulates Intestine Cellular Senescence through m 6 A Modification of Lamin B Receptor. |
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المؤلفون: | Zhang Z; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, China.; Institute of Gastroenterology, Zhejiang University, Zhejiang, China.; Research Center of Prevention and Treatment of Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China., Xue M; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, China.; Institute of Gastroenterology, Zhejiang University, Zhejiang, China.; Research Center of Prevention and Treatment of Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China., Chen J; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, China.; Institute of Gastroenterology, Zhejiang University, Zhejiang, China., Wang Z; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, China.; Institute of Gastroenterology, Zhejiang University, Zhejiang, China.; Research Center of Prevention and Treatment of Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China., Ju F; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, China.; Institute of Gastroenterology, Zhejiang University, Zhejiang, China., Ni J; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, China.; Institute of Gastroenterology, Zhejiang University, Zhejiang, China., Sun J; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, China.; Institute of Gastroenterology, Zhejiang University, Zhejiang, China., Wu H; The Woman's Hospital and the Institute of Genetics, Zhejiang University School of Medicine, Zhejiang, China., Zheng H; The Woman's Hospital and the Institute of Genetics, Zhejiang University School of Medicine, Zhejiang, China., Lou Z; The Woman's Hospital and the Institute of Genetics, Zhejiang University School of Medicine, Zhejiang, China., Zhang Y; Research Center of Prevention and Treatment of Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China.; Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang, China., Yang X; The Woman's Hospital and the Institute of Genetics, Zhejiang University School of Medicine, Zhejiang, China., Chen S; Research Center of Prevention and Treatment of Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China.; Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang, China., Xi Y; The Woman's Hospital and the Institute of Genetics, Zhejiang University School of Medicine, Zhejiang, China., Wang L; Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, China.; Institute of Gastroenterology, Zhejiang University, Zhejiang, China.; Research Center of Prevention and Treatment of Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China. |
المصدر: | Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2022 Dec 19; Vol. 2022, pp. 9096436. Date of Electronic Publication: 2022 Dec 19 (Print Publication: 2022). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101479826 Publication Model: eCollection Cited Medium: Internet ISSN: 1942-0994 (Electronic) Linking ISSN: 19420994 NLM ISO Abbreviation: Oxid Med Cell Longev Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2011- : New York : Hindawi Pub. Corp. Original Publication: 2008-2010: Austin, TX : Landes Bioscience |
مواضيع طبية MeSH: | Drosophila melanogaster*/genetics , Drosophila melanogaster*/metabolism , Cellular Senescence*/genetics, Humans ; Mice ; Animals ; Receptors, Cytoplasmic and Nuclear/genetics ; Phenotype ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Lamin B Receptor |
مستخلص: | N-6-Methyladenosine (m 6 A) modification is involved in multiple biological processes including aging. However, the regulation of m 6 A methyltransferase-like 14 (METTL14) in aging remains unclear. Here, we revealed that the level of m 6 A modification and the expression of METTL14 were particularly decreased in the intestine of aged mice as compared to young mice. Similar results were confirmed in Drosophila melanogaster . Knockdown of Mettl14 in Drosophila resulted in a short lifespan, associated disrupted intestinal integrity, and reduced climbing ability. In human CCD-18Co cells, knockdown of METTL14 accelerated cellular senescence, and the overexpression of METTL14 rescued senescent phenotypes. We also identified the lamin B receptor (LBR) as a target gene for METTL14-mediated m 6 A modification. Knockdown of METTL14 decreased m 6 A level of LBR, resulted in LBR mRNA instability, and thus induced cellular senescence. Our findings suggest that METTL14 plays an essential role in the m 6 A modification-dependent aging process via the regulation of LBR and provides a potential target for cellular senescence. Competing Interests: No potential conflicts of interest were disclosed. (Copyright © 2022 Zizhen Zhang et al.) |
References: | Nucleic Acids Res. 2021 Nov 18;49(20):e116. (PMID: 34417605) Nucleic Acids Res. 2018 May 4;46(8):3906-3920. (PMID: 29529255) Science. 2015 Feb 27;347(6225):1002-6. (PMID: 25569111) Nucleic Acids Res. 2019 Dec 2;47(21):11476. (PMID: 31612919) Biochem J. 2020 Jul 31;477(14):2715-2720. (PMID: 32726434) Aging Cell. 2020 Oct;19(10):e13215. (PMID: 32813328) Nucleic Acids Res. 2020 Nov 4;48(19):11083-11096. (PMID: 33035345) Nucleus. 2010 Jan-Feb;1(1):53-70. (PMID: 21327105) Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21528-33. (PMID: 23236133) Cell. 2017 Nov 2;171(4):877-889.e17. (PMID: 28965759) FEBS J. 2016 May;283(9):1607-30. (PMID: 26645578) Neurosurgery. 2015 Oct;77 Suppl 4:S1-5. (PMID: 26378347) Exp Cell Res. 2020 May 1;390(1):111927. (PMID: 32126237) Mol Cell. 2017 Oct 5;68(1):171-184.e6. (PMID: 28985503) Rejuvenation Res. 2012 Oct;15(5):483-94. (PMID: 23098078) Front Med. 2018 Aug;12(4):481-489. (PMID: 30097961) JPEN J Parenter Enteral Nutr. 2009 Jul-Aug;33(4):411-6. (PMID: 19126762) Mutat Res. 1992 Sep;275(3-6):267-79. (PMID: 1383769) Cell Res. 2018 Jun;28(6):616-624. (PMID: 29789545) Aging Cell. 2018 Jun;17(3):e12753. (PMID: 29573145) Front Oncol. 2020 Jun 11;10:875. (PMID: 32596151) Nucleic Acids Res. 2021 Jun 4;49(10):5537-5552. (PMID: 33999206) Oncogene. 2004 Apr 12;23(16):2919-33. (PMID: 15077154) J Transl Med. 2021 Jun 8;19(1):251. (PMID: 34103054) Nat Commun. 2019 Apr 23;10(1):1898. (PMID: 31015515) Genes Dev. 2015 Jul 1;29(13):1343-55. (PMID: 26159994) Gut. 2020 Jul;69(7):1193-1205. (PMID: 31582403) Age Ageing. 1985 Sep;14(5):312-5. (PMID: 4050610) Aging Cell. 2019 Dec;18(6):e13013. (PMID: 31389184) Cancer Med. 2020 Jan;9(1):278-289. (PMID: 31701672) Cell Death Dis. 2021 Jan 11;12(1):60. (PMID: 33431791) Mol Cell. 2022 May 5;82(9):1660-1677.e10. (PMID: 35320754) Cell Death Dis. 2020 Oct 24;11(10):911. (PMID: 33099572) Nucleic Acids Res. 2016 Jun 2;44(10):e91. (PMID: 26896799) Exp Gerontol. 1992;27(3):321-33. (PMID: 1639152) Cell Rep. 2019 Jan 15;26(3):670-688.e6. (PMID: 30650359) Science. 2018 Sep 28;361(6409):1346-1349. (PMID: 30262497) Nature. 2016 Dec 8;540(7632):242-247. (PMID: 27919077) Aging Cell. 2010 Feb;9(1):54-63. (PMID: 19895632) Sci Adv. 2022 Mar 25;8(12):eabl5723. (PMID: 35333576) Cell. 2021 Oct 28;184(22):5506-5526. (PMID: 34715021) Nat Cell Biol. 2013 Dec;15(12):1495-506. (PMID: 24270890) Ageing Res Rev. 2010 Apr;9(2):101-6. (PMID: 19664726) Nature. 2010 Mar 25;464(7288):503. (PMID: 20336131) Nat Rev Cancer. 2013 May;13(5):357-65. (PMID: 23612461) Cell. 2016 Aug 11;166(4):822-839. (PMID: 27518561) Elife. 2022 Jan 31;11:. (PMID: 35098923) Front Genet. 2021 Mar 19;12:650803. (PMID: 33815484) Genome Biol. 2021 Jan 5;22(1):17. (PMID: 33402207) Mech Ageing Dev. 2019 Mar;178:25-32. (PMID: 30615890) Mol Cancer. 2019 Jun 24;18(1):112. (PMID: 31230592) Elife. 2020 Jan 20;9:. (PMID: 31944178) BMJ Open Diabetes Res Care. 2020 Jul;8(1):. (PMID: 32719079) Nucleic Acids Res. 2021 Jul 21;49(13):7389-7405. (PMID: 34181735) Cell. 2017 Jun 15;169(7):1187-1200. (PMID: 28622506) Semin Cell Dev Biol. 2017 Jun;66:81-93. (PMID: 28161556) |
المشرفين على المادة: | 0 (Receptors, Cytoplasmic and Nuclear) EC 2.1.1.- (Methyltransferases) EC 2.1.1.- (METTL14 protein, human) |
تواريخ الأحداث: | Date Created: 20221229 Date Completed: 20221230 Latest Revision: 20231213 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC9792243 |
DOI: | 10.1155/2022/9096436 |
PMID: | 36578521 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1942-0994 |
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DOI: | 10.1155/2022/9096436 |