دورية أكاديمية
أعرض في EDS

Antibacterial constituents of Rumex nepalensis spreng and its emodin derivatives.

التفاصيل البيبلوغرافية
العنوان: Antibacterial constituents of Rumex nepalensis spreng and its emodin derivatives.
المؤلفون: Nguengang RT; Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, Yaoundé, Cameroon.; Department of Chemistry, Higher Teacher Training College, University of Yaoundé 1, Yaoundé, Cameroon., Tchegnitegni BT; Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Ateba JET; Department of Process Engineering, National Polytechnique School, University of Douala, Douala, Cameroon., Tabekoueng GB; Department of Chemistry, Higher Teacher Training College, University of Yaoundé 1, Yaoundé, Cameroon., Awantu AF; Department of Chemistry, Faculty of Science, The University of Bamenda, Bambili, Cameroon., Bankeu JJK; Department of Chemistry, Faculty of Science, The University of Bamenda, Bambili, Cameroon., Chouna JR; Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Nkenfou CN; Department of Biology, Higher Teacher Training College, University of Yaoundé 1, Yaoundé, Cameroon., Sewald N; Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, Bielefeld, Germany., Lenta BN; Department of Chemistry, Higher Teacher Training College, University of Yaoundé 1, Yaoundé, Cameroon.
المصدر: Natural product research [Nat Prod Res] 2023 Nov-Dec; Vol. 37 (23), pp. 3935-3946. Date of Electronic Publication: 2022 Dec 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003-
مواضيع طبية MeSH: Emodin*/pharmacology , Rumex*/chemistry, Plant Extracts/chemistry ; Bacteria ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Microbial Sensitivity Tests
مستخلص: The CH 2 Cl 2 -MeOH (1:1) extract of roots of Rumex nepalensis (Polygonaceae) displayed significant antibacterial activity against five bacterial strains with MICs (62.5-31.2 μg.mL -1 ). The EtOAc soluble fraction displayed a significant activity against the same strains with MICs (31.2-3.9 μg.mL -1 ). The purification of the EtOAc fraction yielded one new phenylisobenzofuranone derivative, berquaertiide ( 1 ), along with 19 known compounds ( 2 - 20 ). Their structures were elucidated based on the analysis of their NMR and MS data. All the isolated compounds were assessed for their antibacterial activity. Compound 2 was the most active against all the tested strains (15.7 to 1.9 μg.mL -1 ), while compounds 3 - 7 displayed good activities on at least one of the tested strains. In addition, seven analogues ( 21 - 27 ) of compound 2 were prepared and further assessed for their antibacterial activity. Compounds 26 and 27 were most active than 2 against Salmonella enterica and Klebsiella pneumoniae with MIC (125 and 15.6 μg.mL -1 , respectively).
فهرسة مساهمة: Keywords: Rumex nepalensis; antibacterial activity; emodin; phenylbenzofuranone; polygonaceae
المشرفين على المادة: KA46RNI6HN (Emodin)
0 (Plant Extracts)
0 (Anti-Bacterial Agents)
تواريخ الأحداث: Date Created: 20221230 Date Completed: 20231127 Latest Revision: 20231127
رمز التحديث: 20240829
DOI: 10.1080/14786419.2022.2162894
PMID: 36584290
قاعدة البيانات: MEDLINE
الوصف
تدمد:1478-6427
DOI:10.1080/14786419.2022.2162894