دورية أكاديمية
An opinion on the debatable function of brain resident immune protein, T-cell receptor beta subunit in the central nervous system.
العنوان: | An opinion on the debatable function of brain resident immune protein, T-cell receptor beta subunit in the central nervous system. |
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المؤلفون: | Komal P; Department of Biological Sciences, Birla Institute of Technology and Sciences (BITS)-Pilani (Hyderabad Campus), Shameerpet, Mandal, Hyderabad, Telangana 500078, India., Manjari SKV; Department of Biological Sciences, Birla Institute of Technology and Sciences (BITS)-Pilani (Hyderabad Campus), Shameerpet, Mandal, Hyderabad, Telangana 500078, India., Nashmi R; Department of Biology, Division of Medical Sciences, University of Victoria, PO Box 3020, Station CSC, Victoria, BC, V8W 3N5, Canada. |
المصدر: | IBRO neuroscience reports [IBRO Neurosci Rep] 2022 Sep 06; Vol. 13, pp. 235-242. Date of Electronic Publication: 2022 Sep 06 (Print Publication: 2022). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101775148 Publication Model: eCollection Cited Medium: Internet ISSN: 2667-2421 (Electronic) Linking ISSN: 26672421 NLM ISO Abbreviation: IBRO Neurosci Rep Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [Amsterdam] : Elsevier B.V., [2021]- |
مستخلص: | In recent years scientific research has established that the nervous and immune systems have shared molecular signaling components. Proteins native to immune cells, which are also found in the brain, have neuronal functions in the nervous system where they affect synaptic plasticity, axonal regeneration, neurogenesis, and neurotransmission. Certain native immune molecules like major histocompatibility complex I (MHC-I), paired immunoglobulin receptor B (PirB), toll-like receptor (TLR), cluster of differentiation-3 zeta (CD3ζ), CD4 co-receptor, and T-cell receptor beta (TCR-β) expression in neurons have been extensively documented. In this review, we provide our opinion and discussed the possible roles of T-cell receptor beta subunits in modulating the function of neurons in the central nervous system. Based on the previous findings of Syken and Shatz., 2003; Nishiyori et al., 2004; Rodriguez et., 1993 and Komal et., 2014; we discuss whether restrictive expression of TCR-β subunits in selected brain regions could be involved in the pathology of neurological disorders and whether their aberrant enhancement in expression may be considered as a suitable biomarker for aging or neurodegenerative diseases like Huntington's disease (HD). Competing Interests: The authors declare no conflict of interest. (© 2022 The Authors.) |
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فهرسة مساهمة: | Keywords: AD, Alzheimer's disease; CP-AMPA, calcium-permeable α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; Central nervous system (CNS); HD, Huntington's disease; Immune receptors; LTP, long-term potentiation; Major histocompatibility complex I (MHC-I); NMDA, N-methyl-D-aspartate; Neurodegeneration; PD, Parkinson's disease; T-cell receptors (TCRs); TAP-1, transporter associated with antigen processing 1; α7 nAChRs, alpha7 nicotinic acetylcholine receptors |
تواريخ الأحداث: | Date Created: 20230102 Latest Revision: 20230103 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC9795316 |
DOI: | 10.1016/j.ibneur.2022.09.003 |
PMID: | 36590097 |
قاعدة البيانات: | MEDLINE |
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