دورية أكاديمية
أعرض في EDS

Attenuated humoral responses in HIV after SARS-CoV-2 vaccination linked to B cell defects and altered immune profiles.

التفاصيل البيبلوغرافية
العنوان: Attenuated humoral responses in HIV after SARS-CoV-2 vaccination linked to B cell defects and altered immune profiles.
المؤلفون: Touizer E; Institute for Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK., Alrubayyi A; Institute for Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK.; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Ford R; Institute for Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK., Hussain N; Institute for Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK., Gerber PP; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, UK., Shum HL; Institute for Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK., Rees-Spear C; Institute for Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK., Muir L; Institute for Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK., Gea-Mallorquí E; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Kopycinski J; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Jankovic D; Institute for Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK., Jeffery-Smith A; Institute for Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK., Pinder CL; Institute for Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK., Fox TA; Institute for Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK., Williams I; Mortimer Market Centre, Department of HIV, Central and North West London NHS Trust, London, UK., Mullender C; Institute for Global Health, University College London, London, UK., Maan I; Mortimer Market Centre, Department of HIV, Central and North West London NHS Trust, London, UK.; Institute for Global Health, University College London, London, UK., Waters L; Mortimer Market Centre, Department of HIV, Central and North West London NHS Trust, London, UK., Johnson M; Institute for Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK.; The Ian Charleson Day Centre, Royal Free Hospital NHS Foundation Trust, London, UK., Madge S; The Ian Charleson Day Centre, Royal Free Hospital NHS Foundation Trust, London, UK., Youle M; Institute for Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK.; The Ian Charleson Day Centre, Royal Free Hospital NHS Foundation Trust, London, UK., Barber TJ; Institute for Global Health, University College London, London, UK.; The Ian Charleson Day Centre, Royal Free Hospital NHS Foundation Trust, London, UK., Burns F; Institute for Global Health, University College London, London, UK.; The Ian Charleson Day Centre, Royal Free Hospital NHS Foundation Trust, London, UK., Kinloch S; Institute for Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK.; The Ian Charleson Day Centre, Royal Free Hospital NHS Foundation Trust, London, UK., Rowland-Jones S; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Gilson R; Mortimer Market Centre, Department of HIV, Central and North West London NHS Trust, London, UK.; Institute for Global Health, University College London, London, UK., Matheson NJ; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, UK.; NHS Blood and Transplant, Cambridge, UK., Morris E; Institute for Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK., Peppa D; Institute for Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK.; Mortimer Market Centre, Department of HIV, Central and North West London NHS Trust, London, UK.; The Ian Charleson Day Centre, Royal Free Hospital NHS Foundation Trust, London, UK., McCoy LE; Institute for Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK.
المصدر: IScience [iScience] 2023 Jan 20; Vol. 26 (1), pp. 105862. Date of Electronic Publication: 2022 Dec 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, [2018]-
مستخلص: We assessed a cohort of people living with human immunodeficiency virus (PLWH) (n = 110) and HIV negative controls (n = 64) after 1, 2 or 3 SARS-CoV-2 vaccine doses. At all timepoints, PLWH had significantly lower neutralizing antibody (nAb) titers than HIV-negative controls. We also observed a delayed development of neutralization in PLWH that was underpinned by a reduced frequency of spike-specific memory B cells (MBCs). Improved neutralization breadth was seen against the Omicron variant (BA.1) after the third vaccine dose in PLWH but lower nAb responses persisted and were associated with global MBC dysfunction. In contrast, SARS-CoV-2 vaccination induced robust T cell responses that cross-recognized variants in PLWH. Strikingly, individuals with low or absent neutralization had detectable functional T cell responses. These PLWH had reduced numbers of circulating T follicular helper cells and an enriched population of CXCR3 + CD127 + CD8 + T cells after two doses of SARS-CoV-2 vaccination.
Competing Interests: The authors declare no competing interests.
(© 2023 The Authors.)
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معلومات مُعتمدة: MC_PC_20060 United Kingdom MRC_ Medical Research Council; MR/W020556/1 United Kingdom MRC_ Medical Research Council; R01 AI155182 United States AI NIAID NIH HHS; MR/T032413/1 United Kingdom MRC_ Medical Research Council; United Kingdom WT_ Wellcome Trust; MR/R008698/1 United Kingdom MRC_ Medical Research Council
فهرسة مساهمة: Keywords: Immunology; Virology
تواريخ الأحداث: Date Created: 20230102 Latest Revision: 20240214
رمز التحديث: 20240214
مُعرف محوري في PubMed: PMC9788849
DOI: 10.1016/j.isci.2022.105862
PMID: 36590902
قاعدة البيانات: MEDLINE
الوصف
تدمد:2589-0042
DOI:10.1016/j.isci.2022.105862