دورية أكاديمية
A traveling SARS-CoV-2 laboratory as part of a pandemic response among vulnerable Brazilian populations.
| العنوان: | A traveling SARS-CoV-2 laboratory as part of a pandemic response among vulnerable Brazilian populations. |
|---|---|
| المؤلفون: | Elias MC; Instituto Butantan, São Paulo, Brazil. carolina.eliassabbaga@butantan.gov.br.; Center of Toxins, Immune Response and Cell Signaling - CeTICSInstituto Butantan, São Paulo, 05503-900, Brazil. carolina.eliassabbaga@butantan.gov.br., Slavov SN; University of São Paulo, Ribeirão Preto Medical School, Blood Center of Ribeirão Preto, Ribeirão Preto, Brazil., Lima ARJ; Instituto Butantan, São Paulo, Brazil., Martins AJ; Instituto Butantan, São Paulo, Brazil., Barros CRDS; Instituto Butantan, São Paulo, Brazil., Moretti DB; Instituto Butantan, São Paulo, Brazil., Araujo EL; Loccus, São Paulo, Brazil., Marqueze EC; Instituto Butantan, São Paulo, Brazil., Ribeiro G; Instituto Butantan, São Paulo, Brazil., Ribeiro GMF; Instituto Butantan, São Paulo, Brazil., Bernardino JST; Instituto Butantan, São Paulo, Brazil., Koser JR; Instituto Butantan, São Paulo, Brazil., Clemente LG; Centro de Genomica Funcional, ESALQ-USP, Piracicaba, São Paulo, Brasil., Crispin LAC; Instituto Butantan, São Paulo, Brazil., Alcantara LCJ; Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil., Coutinho LL; Centro de Genomica Funcional, ESALQ-USP, Piracicaba, São Paulo, Brasil., Giovanetti M; Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil., Silva QO; Instituto Butantan, São Paulo, Brazil., Neto RM; Instituto Butantan, São Paulo, Brazil., Haddad R; Instituto Butantan, São Paulo, Brazil., Kashima S; University of São Paulo, Ribeirão Preto Medical School, Blood Center of Ribeirão Preto, Ribeirão Preto, Brazil., Viala VL; Instituto Butantan, São Paulo, Brazil., Covas DT; Instituto Butantan, São Paulo, Brazil.; University of São Paulo, Ribeirão Preto Medical School, Blood Center of Ribeirão Preto, Ribeirão Preto, Brazil., Sampaio SC; Instituto Butantan, São Paulo, Brazil. sandra.coccuzzo@butantan.gov.br. |
| المصدر: | BMC public health [BMC Public Health] 2023 Jan 03; Vol. 23 (1), pp. 15. Date of Electronic Publication: 2023 Jan 03. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 100968562 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2458 (Electronic) Linking ISSN: 14712458 NLM ISO Abbreviation: BMC Public Health Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, [2001- |
| مواضيع طبية MeSH: | SARS-CoV-2* , COVID-19*/diagnosis , COVID-19*/epidemiology, Humans ; COVID-19 Testing ; Brazil/epidemiology ; Pandemics/prevention & control ; Vulnerable Populations |
| مستخلص: | Background: Brazil has been dramatically hit by the SARS-CoV-2 pandemic and is a world leader in COVID-19 morbidity and mortality. Additionally, the largest country of Latin America has been a continuous source of SARS-CoV-2 variants and shows extraordinary variability of the pandemic strains probably related to the country´s outstanding position as a Latin American economical and transportation hub. Not all regions of the country show sufficient infrastructure for SARS-CoV-2 diagnosis and genotyping which can negatively impact the pandemic response. Methods: Due to this reason and to disburden the diagnostic system of the inner São Paulo State, the Butantan Institute established the Mobile Laboratory (in Portuguese: LabMovel) for SARS-CoV-2 testing which started a trip of the most important "hotspots" of the most populous Brazilian region. The LabMovel initiated in two important cities of the State: Aparecida do Norte (an important religious center) and the Baixada Santista region which incorporates the port of Santos, the busiest in Latin America. The LabMovel was fully equipped with an automatized system for SARS-CoV-2 diagnosis and sequencing/genotyping. It also integrated the laboratory systems for patient records and results divulgation including in the Federal Brazilian Healthcare System. Results: Currently,16,678 samples were tested, among them 1,217 from Aparecida and 4,564 from Baixada Santista. We tracked the delta introductio in the tested regions with its high diversification. The established mobile SARS-CoV-2 laboratory had a major impact on the Public Health System of the included cities including timely delivery of the results to the healthcare agents and the Federal Healthcare system, evaluation of the vaccination status of the positive individuals in the background of exponential vaccination process in Brazil and scientific and technological divulgation of the fieldwork to the most vulnerable populations. Conclusions: The SARS-CoV-2 pandemic has demonstrated worldwide the importance of science to fight against this viral agent and the LabMovel shows that it is possible to integrate researchers, clinicians, healthcare workers and patients to take rapid actions that can in fact mitigate this and other epidemiological situations. (© 2022. The Author(s).) |
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| معلومات مُعتمدة: | CRP/BRA20-03 ICEGEB; Contract CRP/20/03. ICEGEB; 301677/2018-2 Conselho Nacional de Desenvolvimento Científico e Tecnológico; 306199/2018-1 Conselho Nacional de Desenvolvimento Científico e Tecnológico; 2020/10127-1 Fundação de Amparo à Pesquisa do Estado de São Paulo; 2020/00694-6 Fundação de Amparo à Pesquisa do Estado de São Paulo; 312003/2020-0 Conselho Nacional de Desenvolvimento Científico e Tecnológico; 304353/2019-1 Conselho Nacional de Desenvolvimento Científico e Tecnológico; 2018/15826-5 Fundação de Amparo à Pesquisa do Estado de São Paulo; E-26/202.665/2019(247400) Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; 2013/07467-1 Fundação de Amparo à Pesquisa do Estado de São Paulo; U01 AI151698 United States NH NIH HHS; U01 AI151698 United States AI NIAID NIH HHS; E-26/202.248/2018 (238504) Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro |
| فهرسة مساهمة: | Keywords: Brazil; COVID-19; LabMovel; Molecular surveillance; Real-time detection; SARS-CoV-2 |
| SCR Organism: | SARS-CoV-2 variants |
| تواريخ الأحداث: | Date Created: 20230103 Date Completed: 20230105 Latest Revision: 20230220 |
| رمز التحديث: | 20230220 |
| مُعرف محوري في PubMed: | PMC9810251 |
| DOI: | 10.1186/s12889-022-14867-2 |
| PMID: | 36597102 |
| قاعدة البيانات: | MEDLINE |
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