دورية أكاديمية
Targeting N-type calcium channels in young-onset of some neurological diseases.
| العنوان: | Targeting N-type calcium channels in young-onset of some neurological diseases. |
|---|---|
| المؤلفون: | Antunes FTT; Department of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada.; 2 Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada., De Souza AH; 3 Post-Graduate Program of Health Sciences, Faculdade de Ciências Médicas de, Belo Horizonte, Minas Gerais, Brazil., Figueira J; 4 Pharmacology Department, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil., Binda NS; 4 Pharmacology Department, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil., Carvalho VPR; 3 Post-Graduate Program of Health Sciences, Faculdade de Ciências Médicas de, Belo Horizonte, Minas Gerais, Brazil., Vieira LB; Pharmacology Departament, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Gomez MV; 6 Graduate Program in Health Sciences, Faculty Santa Casa BH, Belo Horizonte, Minas Gerais, Brazil. |
| المصدر: | Frontiers in cell and developmental biology [Front Cell Dev Biol] 2022 Dec 19; Vol. 10, pp. 1090765. Date of Electronic Publication: 2022 Dec 19 (Print Publication: 2022). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101630250 Publication Model: eCollection Cited Medium: Print ISSN: 2296-634X (Print) Linking ISSN: 2296634X NLM ISO Abbreviation: Front Cell Dev Biol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Media S.A., [2013]- |
| مستخلص: | Calcium (Ca 2+ ) is an important second messenger in charge of many critical processes in the central nervous system (CNS), including membrane excitability, neurotransmission, learning, memory, cell proliferation, and apoptosis. In this way, the voltage-gated calcium channels (VGCCs) act as a key supply for Ca 2+ entry into the cytoplasm and organelles. Importantly, the dysregulation of these channels has been reported in many neurological diseases of young-onset, with associated genetic factors, such as migraine, multiple sclerosis, and Huntington's disease. Notably, the literature has pointed to the role of N-type Ca 2+ channels (NTCCs) in controlling a variety of processes, including pain, inflammation, and excitotoxicity. Moreover, several Ca 2+ channel blockers that are used for therapeutic purposes have been shown to act on the N-type channels. Therefore, this review provides an overview of the NTCCs in neurological disorders focusing mainly on Huntington's disease, multiple sclerosis, and migraine. It will discuss possible strategies to generate novel therapeutic strategies. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Antunes, De Souza, Figueira, Binda, Carvalho, Vieira and Gomez.) |
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| فهرسة مساهمة: | Keywords: Cav2.2 channels; N-type calcium channel; huntington disease (HD); migraine; multiple sclerosis (MS); voltage-gated calcium channel (VGCC) |
| تواريخ الأحداث: | Date Created: 20230105 Latest Revision: 20230111 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9806183 |
| DOI: | 10.3389/fcell.2022.1090765 |
| PMID: | 36601540 |
| قاعدة البيانات: | MEDLINE |
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