دورية أكاديمية
High-dose Chemotherapy Impairs Cardiac Autonomic Control of Hospitalized Cancer Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation.
| العنوان: | High-dose Chemotherapy Impairs Cardiac Autonomic Control of Hospitalized Cancer Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation. |
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| المؤلفون: | de Almeida LB; Cardiovascular Research Unit and Exercise Physiology, Federal University of Juiz de Fora, Juiz de Fora, Brazil. Electronic address: almeidalb@hotmail.com., Laterza MC; Cardiovascular Research Unit and Exercise Physiology, Federal University of Juiz de Fora, Juiz de Fora, Brazil; Master´s Program on Rehabilitation Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil., Rondon MUPB; School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil., Toschi-Dias E; Methodist University of São Paulo, São Paulo, Brazil., de Matos LDNJ; Hospital Israelita Albert Einstein, São Paulo, Brazil., Oliveira CC; Master´s Program on Rehabilitation Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil., Trevizan PF; Department of Physical Therapy, Federal University of Minas Gerais, Belo Horizonte, Brazil., Martinez DG; Cardiovascular Research Unit and Exercise Physiology, Federal University of Juiz de Fora, Juiz de Fora, Brazil; Master´s Program on Rehabilitation Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil. |
| المصدر: | Clinical lymphoma, myeloma & leukemia [Clin Lymphoma Myeloma Leuk] 2023 Mar; Vol. 23 (3), pp. e131-e138. Date of Electronic Publication: 2022 Dec 20. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101525386 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2152-2669 (Electronic) Linking ISSN: 21522669 NLM ISO Abbreviation: Clin Lymphoma Myeloma Leuk Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2011-: [New York] : Elsevier Original Publication: Dallas, Tex. : Cancer Media Group |
| مواضيع طبية MeSH: | Autonomic Nervous System*/drug effects , Autonomic Nervous System*/physiology , Hematopoietic Stem Cell Transplantation* , Neoplasms*/drug therapy , Antineoplastic Agents*/adverse effects , Antineoplastic Agents*/therapeutic use, Humans ; Cardiotoxicity ; Transplantation, Autologous ; Troponin I |
| مستخلص: | Background: Autologous hematopoietic stem cell transplantation (HSCT) patients have intermediary and late cardiac autonomic dysfunction, which is an independent mortality predictor. However, it is unknown when this HSCT-related autonomic dysfunction begins during hospitalization for HSCT and whether cardiac autonomic control (CAC) is related to cardiotoxicity in these patients. Patients and Methods: CAC was assessed in 36 autologous-HSCT inpatients (HSCT group) and 23 cancer-free outpatients (CON group) using heart rate variability analysis. The HSCT group was assessed at five time-points from admission to hospital discharge during hospitalization period. The CON group was assessed once. The severity of cardiotoxicity (CTCAE 5.0) and cardiac troponin I were recorded. Results: The CAC was significantly reduced after high-dose chemotherapy (HDC) (reduction of MNN, SDNN, RMSSD, LFms 2 and HFnu, and increase of LFnu and LF/HF; P<0.05). At the onset of neutropenia, pNN50 and HFms 2 were also reduced (P<0.05) compared to the admission ones. Although both groups were similar regarding CAC at hospital admission, the HSCT patients showed impaired CAC at hospital discharge (P<0.05). The LF/HF was positively associated with cardiac troponin I and RMSSD was inversely associated with the severity of cardiotoxicity (P≤0.05). Conclusion: CAC worsened during hospitalization for autologous-HSCT, mainly after HDC. In addition, it seems associated to early signs of cardiotoxicity in these patients. Competing Interests: Disclosure The authors have stated that they have no conflicts of interest. (Copyright © 2022 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Autologous transplantation; Autonomic nervous system; Bone marrow transplantation; Cardiotoxicity; Hematologic neoplasms |
| المشرفين على المادة: | 0 (Troponin I) 0 (Antineoplastic Agents) |
| تواريخ الأحداث: | Date Created: 20230105 Date Completed: 20230228 Latest Revision: 20230320 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.clml.2022.12.010 |
| PMID: | 36604245 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2152-2669 |
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| DOI: | 10.1016/j.clml.2022.12.010 |