دورية أكاديمية
[Enhancing effects of chemical permeation enhancer propylene glycol and ultrasonic technology on transdermal permeation of Baimai Ointment].
| العنوان: | [Enhancing effects of chemical permeation enhancer propylene glycol and ultrasonic technology on transdermal permeation of Baimai Ointment]. |
|---|---|
| المؤلفون: | Zhu YY; School of Chinese Materia Medica, Beijing University of Chinses Medicine Beijing 102488, China., Liang J; School of Chinese Materia Medica, Beijing University of Chinses Medicine Beijing 102488, China., Xiao WQ; School of Chinese Materia Medica, Beijing University of Chinses Medicine Beijing 102488, China., Ren ZY; School of Chinese Materia Medica, Beijing University of Chinses Medicine Beijing 102488, China., Zhong WL; School of Chinese Materia Medica, Beijing University of Chinses Medicine Beijing 102488, China., Li HH; School of Chinese Materia Medica, Beijing University of Chinses Medicine Beijing 102488, China., Xi C; School of Chinese Materia Medica, Beijing University of Chinses Medicine Beijing 102488, China., Wu HC; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine Beijing 102488, China., DU SY; School of Chinese Materia Medica, Beijing University of Chinses Medicine Beijing 102488, China. |
| المصدر: | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2022 Dec; Vol. 47 (24), pp. 6607-6614. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Country of Publication: China NLM ID: 8913656 Publication Model: Print Cited Medium: Print ISSN: 1001-5302 (Print) Linking ISSN: 10015302 NLM ISO Abbreviation: Zhongguo Zhong Yao Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Beijing : Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Original Publication: [Beijing] : Zhongguo yao xue hui : [Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo, 1989- |
| مواضيع طبية MeSH: | Curcumin*/pharmacology , Ammonium Compounds*/metabolism , Ammonium Compounds*/pharmacology, Mice ; Animals ; Skin Absorption ; Ultrasonics ; Administration, Cutaneous ; Skin ; Propylene Glycol/metabolism ; Propylene Glycol/pharmacology ; Permeability |
| مستخلص: | This study aimed to improve the transdermal permeation quantity of Baimai Ointment by investigating the enhancing effects of physical and chemical permeation promoting methods on transdermal permeation of Baimai Ointment. The improved Franz diffusion cell method was used for in vitro transdermal experiment. The abdominal skin of mice was used, and the skin was treated with 3% propylene glycol in the chemical enhancement group. Ultrasonic technology was introduced in the physical enhancement group. The conditions of ultrasonic technology were optimized by single factor trial. Taking Q_(EF) and ER as the indexes of penetration promotion performance, the enhancing effects of the two methods were compared. The results showed that the promotion performance of 3% propylene glycol for ammonium glycyrrhizinate, nardosinone and curcumin of the chemical enhancement group were 1.74, 1.60, and 3.73 times higher than those of the blank group, respectively. The overall permeation efficiency of the Baimai Ointment was significantly improved. The comprehensive promoting effect on each component was curcumin>ammonium glycyrrhizinate>nardosinone. In the physical enhancement group, the penetration promoting effect of ultrasonic power 1.0 W was better than that of 2.0 W and 0.5 W, ultrasonic time 5 min was better than 3 min and 8 min, and the ultrasonic frequency 1 MHz was better than 3 MHz. Therefore, the optimal ultrasonic condition was 1.0 W-5 min-1 MHz. Under this condition, in terms of the transdermal permeation for ammonium glycyrrhizinate, the Q_(EF) and ER of the ultrasonic technology were better than those of 3% propylene glycol. In terms of the transdermal permeation for nardosinone and curcumin, the QEF and ER of 3% propylene glycol were better than those of the ultrasonic technology. Therefore, 3% propylene glycol combined with ultrasonic technology can be used to promote permeation of Baimai Ointment that contains both water-soluble and fat-soluble components in the clinical application. This study provides a theoretical basis for the clinical application of Baimai Ointment and other transdermal preparations. |
| فهرسة مساهمة: | Keywords: Baimai Ointment; chemical permeation enhancer; propylene glycol; transdermal permeation; ultrasonic permeation enhancement technology |
| المشرفين على المادة: | 23720-80-1 (nardosinone) 0 (baimai ointment) IT942ZTH98 (Curcumin) 6DC9Q167V3 (Propylene Glycol) 0 (Ammonium Compounds) |
| تواريخ الأحداث: | Date Created: 20230106 Date Completed: 20230109 Latest Revision: 20230111 |
| رمز التحديث: | 20240628 |
| DOI: | 10.19540/j.cnki.cjcmm.20220422.301 |
| PMID: | 36604909 |
| قاعدة البيانات: | MEDLINE |
كن أول من يترك تعليقا!