دورية أكاديمية
CRISPR-Cas9 base editors and their current role in human therapeutics.
العنوان: | CRISPR-Cas9 base editors and their current role in human therapeutics. |
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المؤلفون: | Lahr WS; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA; Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, USA; Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota, USA; Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA., Sipe CJ; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA; Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, USA; Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota, USA; Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA., Skeate JG; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA; Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, USA; Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota, USA; Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA., Webber BR; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA; Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, USA; Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota, USA., Moriarity BS; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA; Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, USA; Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota, USA; Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA. Electronic address: mori0164@umn.edu. |
المصدر: | Cytotherapy [Cytotherapy] 2023 Mar; Vol. 25 (3), pp. 270-276. Date of Electronic Publication: 2023 Jan 10. |
نوع المنشور: | Review; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 100895309 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-2566 (Electronic) Linking ISSN: 14653249 NLM ISO Abbreviation: Cytotherapy Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2013- : London : Elsevier Original Publication: Oxford, England : ISIS Medical Media, c1999- |
مواضيع طبية MeSH: | CRISPR-Cas Systems*/genetics , Gene Editing*, Humans ; Genetic Therapy ; DNA |
مستخلص: | Background: Consistent progress has been made to create more efficient and useful CRISPR-Cas9-based molecular toolsfor genomic modification. Methods: This review focuses on recent articles that have employed base editors (BEs) for both clinical and research purposes. Results: CRISPR-Cas9 BEs are a useful system because of their highefficiency and broad applicability to gene correction and disruption. In addition, base editing has beensuggested as a safer approach than other CRISPR-Cas9-based systems, as it limits double-strand breaksduring multiplex gene knockout and does not require a toxic DNA donor molecule for genetic correction. Conclusion: As such, numerous industry and academic groups are currently developing base editing strategies withclinical applications in cancer immunotherapy and gene therapy, which this review will discuss, with a focuson current and future applications of in vivo BE delivery. (Published by Elsevier Inc.) |
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معلومات مُعتمدة: | R01 AI161017 United States AI NIAID NIH HHS; T32 HL007062 United States HL NHLBI NIH HHS; R21 CA237789 United States CA NCI NIH HHS; P50 CA136393 United States CA NCI NIH HHS; R21 AI163731 United States AI NIAID NIH HHS; P01 CA254849 United States CA NCI NIH HHS; R01 AI146009 United States AI NIAID NIH HHS |
فهرسة مساهمة: | Keywords: base editor; cancer immunotherapy; gene therapy; hematopoietic stem cell; multiplex gene editing; sickle cell |
المشرفين على المادة: | 10191-18-1 (BES) 9007-49-2 (DNA) |
تواريخ الأحداث: | Date Created: 20230112 Date Completed: 20230207 Latest Revision: 20240617 |
رمز التحديث: | 20240617 |
مُعرف محوري في PubMed: | PMC10887149 |
DOI: | 10.1016/j.jcyt.2022.11.013 |
PMID: | 36635153 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1477-2566 |
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DOI: | 10.1016/j.jcyt.2022.11.013 |